N4-(Dialkylamino)methylene Derivatives of 2′-Deoxycytidine and Arabinocytidine: Physicochemical Studies for Potential Prodrug Applications

The synthesis and physicochemical parameters of a series ofN4-(N,N-dialkyl)formamidine derivatives of 2′-deoxycytidine (dCyd,1) and arabinocytidine (ara-C,2), as prodrug prototypes, are described. The lipophilicity of the formamidine derivatives compared to that of the parent nucleosides increased 1...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1994-04, Vol.83 (4), p.582-586
Hauptverfasser:	Kerr, Stephen G., Kalman, Thomas I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chemical Phenomena Chemistry, Physical Cytarabine - analogs & derivatives Cytarabine - chemistry Cytarabine - therapeutic use Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Deoxycytidine - therapeutic use Drug Stability Half-Life Hydrolysis Kinetics Leukemia L1210 - drug therapy Lipids - chemistry Medical sciences Mice Pharmacology. Drug treatments Prodrugs - chemistry Solubility
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