Use of [6,6- 2H 2]Glucose and of Low-Enrichment [U- 13C 6]-Glucose for Sequential or Simultaneous Measurements of Glucose Turnover by Gas Chromatography-Mass Spectrometry

We developed gas chromatography-mass spectrometric methods for assaying the enrichment of 99 at.% [6,6- 2H 2]glucose and 30 at.% [U- 13C 6]glucose, although both tracers are mostly M + 2. 13C enrichment is determined either by the C-1 to C-5 fragment of glucose aldonitrile pentaacetate or by oxidati...

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