Methotrexate-loaded, photosensitized erythrocytes: a photo-activatable carrier/delivery system for use in cancer therapy

With a view towards the design of a system incorporating both the use of chemotherapeutics and photodynamic therapy for use in cancer treatment modalities, erythrocytes have been loaded with methotrexate and subsequently photosensitized by exposure to hematoporphyrin derivative. Loading of methotrex...

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Veröffentlicht in:	Cancer letters 1994-07, Vol.82 (2), p.225-229
Hauptverfasser:	Flynn, G., McHale, L., McHale, A.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cancer Chemotherapy Controlled release Drug Carriers Electroporation Erythrocyte Aging Erythrocyte Transfusion - methods Erythrocytes Erythrocytes - drug effects HeLa Cells Hematoporphyrin derivative Hematoporphyrins - pharmacology Humans Medical sciences Methotrexate - administration & dosage Neoplasms - therapy Pharmacology. Drug treatments Photodynamic therapy Phototherapy Rabbits
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