Evaluation of Hepatic Metabolism of Salicylic Acid in Perfused Rat Liver

Hepatic metabolism of salicylic acid was studied using a single-pass liver perfusion technique. Livers obtained from male, Sprague-Dawley rats (200–300 g) were perfused with Krebs-Henseleit bicarbonate buffer containing the drug (50–100 μg/mL) and glycine (0.5 or 5 mM) or glucose (5.5 mM) or bovine...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1994-04, Vol.83 (4), p.607-608
Hauptverfasser:	Shetty, Bhasker V., Badr, Mostafa, Melethil, Srikumaran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glycine - metabolism In Vitro Techniques Liver - metabolism Male Oxygen Consumption - physiology Perfusion Rats Rats, Sprague-Dawley Salicylates - metabolism Salicylic Acid
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