Chromosomal fragility associated with familial Alzheimer's disease

To test whether chromosomal instability is associated with familial Alzheimer's disease, we examined breakage on X chromosomes of fibroblasts derived from patients with familial Alzheimer's disease, using gene cotransfer methodology. The X chromosome is a convenient target for analyzing DN...

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Veröffentlicht in:	Annals of neurology 1994-08, Vol.36 (2), p.190-199
Hauptverfasser:	Ettinger, Susan, Weksler, Marc E., Zhou, Xianting, Blass, John, Szabo, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	12E7 Antigen Aged Alzheimer Disease - enzymology Alzheimer Disease - genetics Antigens, CD Biological and medical sciences Cell Adhesion Molecules - genetics Chromosome Deletion Chromosome Fragility Chromosome Mapping Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Genetic Linkage Glucosephosphate Dehydrogenase - genetics Humans Hypoxanthine Phosphoribosyltransferase - genetics Medical sciences Membrane Glycoproteins - genetics Middle Aged Neurology X Chromosome
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