Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas
Well‐differentiated liposarcomas (WDLPS) are frequently characterized by a near‐diploid karyotype with supernumerary ring and/or giant rod‐shaped marker chromosomes. We have shown, using fluorescence in situ hybridization (FISH) and molecular strategies, that these markers contain chromosome 12‐deri...
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| Veröffentlicht in: | Genes chromosomes & cancer 1994-04, Vol.9 (4), p.292-295 |
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| creator | Suijkerbuijk, Ron F. Weghuis, Daniel E. M. Olde Van Den Berg, Margot Van Kessel, Ad Geurts Pedeutour, Florence Turc-Carel, Claude Forus, Anne Myklebost, Ola Glier, Cliff |
| description | Well‐differentiated liposarcomas (WDLPS) are frequently characterized by a near‐diploid karyotype with supernumerary ring and/or giant rod‐shaped marker chromosomes. We have shown, using fluorescence in situ hybridization (FISH) and molecular strategies, that these markers contain chromosome 12‐derived sequences. Here we report the analysis of six WDLPS for the presence of amplified DNA segments by means of the recently developed comparative genomic hybridization (CGH) strategy. Two distinct chromosome 12‐derived amplification units could be identified in all tumors examined, one located in the q 14‐q 15 region as expected, the second unexpectedly mapping to q21.3‐q22. Our results indicate that the concerted amplification of these two distinct regions on the long arm of chromosome 12 may be a consistent characteristic of WDLPS. These amplifications are most likely directly related to the presence of supernumerary ring and/or giant marker chromosomes in this group of soft tissue tumors. Genes Chrom Cancer 9:292‐295 (1994). © 1994 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/gcc.2870090410 |
| format | Article |
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Two distinct chromosome 12‐derived amplification units could be identified in all tumors examined, one located in the q 14‐q 15 region as expected, the second unexpectedly mapping to q21.3‐q22. Our results indicate that the concerted amplification of these two distinct regions on the long arm of chromosome 12 may be a consistent characteristic of WDLPS. These amplifications are most likely directly related to the presence of supernumerary ring and/or giant marker chromosomes in this group of soft tissue tumors. 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M. Olde</creatorcontrib><creatorcontrib>Van Den Berg, Margot</creatorcontrib><creatorcontrib>Van Kessel, Ad Geurts</creatorcontrib><creatorcontrib>Pedeutour, Florence</creatorcontrib><creatorcontrib>Turc-Carel, Claude</creatorcontrib><creatorcontrib>Forus, Anne</creatorcontrib><creatorcontrib>Myklebost, Ola</creatorcontrib><creatorcontrib>Glier, Cliff</creatorcontrib><title>Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas</title><title>Genes chromosomes & cancer</title><addtitle>Genes Chromosom. Cancer</addtitle><description>Well‐differentiated liposarcomas (WDLPS) are frequently characterized by a near‐diploid karyotype with supernumerary ring and/or giant rod‐shaped marker chromosomes. We have shown, using fluorescence in situ hybridization (FISH) and molecular strategies, that these markers contain chromosome 12‐derived sequences. Here we report the analysis of six WDLPS for the presence of amplified DNA segments by means of the recently developed comparative genomic hybridization (CGH) strategy. Two distinct chromosome 12‐derived amplification units could be identified in all tumors examined, one located in the q 14‐q 15 region as expected, the second unexpectedly mapping to q21.3‐q22. Our results indicate that the concerted amplification of these two distinct regions on the long arm of chromosome 12 may be a consistent characteristic of WDLPS. These amplifications are most likely directly related to the presence of supernumerary ring and/or giant marker chromosomes in this group of soft tissue tumors. Genes Chrom Cancer 9:292‐295 (1994). © 1994 Wiley‐Liss, Inc.</description><subject>Cell Differentiation</subject><subject>chromosome 12</subject><subject>Chromosomes, Human, Pair 12</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Amplification</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>hybridization</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>liposarcoma</subject><subject>Liposarcoma - genetics</subject><subject>Liposarcoma - pathology</subject><subject>man</subject><subject>Nucleic Acid Hybridization</subject><subject>Ring Chromosomes</subject><issn>1045-2257</issn><issn>1098-2264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEKm3hyg3JJ25ZxnZix0cUYFupFAmKOFqOPWkNSRzsLMvyK_jJeLWrIk69zDx53vtk6RXFCworCsBe31q7Yo0EUFBReFScUlBNyZioHu91VWddy6fFWUrfAEBwVZ8UJ7KmCmp2WvxpwzibaBb_E8ktTmH0ltztuuid_51fw0RMIoYsIQx5EIe9n5As2yx9WvxkF2LvYhhDCiMSykqHMbMcMeM8-N7bA2Qz-SURP5EtDkPpfN9jxGnxZsnWwc8hmWjDaNKz4klvhoTPj_u8-PL-3U17UV59XF-2b65Ky1kFpTWAsnOyqYExZKaiwgEXvOkqqDrVKNW7GkA2TcUUR4F95xgHBrzj-wg_L14duHMMPzaYFj36ZPPnzIRhk7QUgirFxINGKhopodobVwejjSGliL2eox9N3GkKet-Vzl3pf13lwMsjedON6O7tx3LyXR3uWz_g7gGaXrftf-zykM0l4a_7rInftZBc1vrr9Vp_uP5MP61v3uoL_he72LEL</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Suijkerbuijk, Ron F.</creator><creator>Weghuis, Daniel E. 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M. Olde</au><au>Van Den Berg, Margot</au><au>Van Kessel, Ad Geurts</au><au>Pedeutour, Florence</au><au>Turc-Carel, Claude</au><au>Forus, Anne</au><au>Myklebost, Ola</au><au>Glier, Cliff</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosom. Cancer</addtitle><date>1994-04</date><risdate>1994</risdate><volume>9</volume><issue>4</issue><spage>292</spage><epage>295</epage><pages>292-295</pages><issn>1045-2257</issn><eissn>1098-2264</eissn><abstract>Well‐differentiated liposarcomas (WDLPS) are frequently characterized by a near‐diploid karyotype with supernumerary ring and/or giant rod‐shaped marker chromosomes. We have shown, using fluorescence in situ hybridization (FISH) and molecular strategies, that these markers contain chromosome 12‐derived sequences. Here we report the analysis of six WDLPS for the presence of amplified DNA segments by means of the recently developed comparative genomic hybridization (CGH) strategy. Two distinct chromosome 12‐derived amplification units could be identified in all tumors examined, one located in the q 14‐q 15 region as expected, the second unexpectedly mapping to q21.3‐q22. Our results indicate that the concerted amplification of these two distinct regions on the long arm of chromosome 12 may be a consistent characteristic of WDLPS. These amplifications are most likely directly related to the presence of supernumerary ring and/or giant marker chromosomes in this group of soft tissue tumors. 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| ispartof | Genes chromosomes & cancer, 1994-04, Vol.9 (4), p.292-295 |
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| subjects | Cell Differentiation chromosome 12 Chromosomes, Human, Pair 12 DNA, Neoplasm - genetics Gene Amplification Genetic Markers Humans hybridization In Situ Hybridization, Fluorescence liposarcoma Liposarcoma - genetics Liposarcoma - pathology man Nucleic Acid Hybridization Ring Chromosomes |
| title | Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas |
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