Improved haemodynamics but reduced arterial blood oxygenation, at rest and during exercise after long-term oral prazosin therapy in chronic cor pulmonale

The effect of vasodilator therapy in chronic obstructive lung disease with pulmonary hypertension was evaluated in eight patients during oral prazosin therapy (2–10 mg day −l). After one week, prazosin reduced mean pulmonary artery pressure and pulmonary and systemic vascular resistance, and increas...

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