Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection
SUMMARY In a double‐blind, placebo‐controlled, cross‐over trial in 11 patients suffering eight or more episodes of recurrent non‐genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12...
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| Veröffentlicht in: | British journal of dermatology (1951) 1985-12, Vol.113 (6), p.731-735 |
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| container_end_page | 735 |
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| container_issue | 6 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 113 |
| creator | THOMAS, R.H.MEYRICK DODD, H.J. YEO, JANE M. KIRBY, J.D.T. |
| description | SUMMARY
In a double‐blind, placebo‐controlled, cross‐over trial in 11 patients suffering eight or more episodes of recurrent non‐genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, compared with nine during placebo treatment (P=0.016). Although lesion development was effectively suppressed in nine of the patients whilst taking acyclovir, the development of prodromal symptoms, and occasionally erythema, was reported by five. There was no difference between acyclovir and placebo in the time to the next recurrence following completion of treatment. No patient reported any side effects of either placebo or acyclovir therapy. It is believed that this is the first report of any form of oral therapy which is effective in suppressing recurrent non‐genital HSV infection in immunocompetent patients. |
| doi_str_mv | 10.1111/j.1365-2133.1985.tb02409.x |
| format | Article |
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In a double‐blind, placebo‐controlled, cross‐over trial in 11 patients suffering eight or more episodes of recurrent non‐genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, compared with nine during placebo treatment (P=0.016). Although lesion development was effectively suppressed in nine of the patients whilst taking acyclovir, the development of prodromal symptoms, and occasionally erythema, was reported by five. There was no difference between acyclovir and placebo in the time to the next recurrence following completion of treatment. No patient reported any side effects of either placebo or acyclovir therapy. It is believed that this is the first report of any form of oral therapy which is effective in suppressing recurrent non‐genital HSV infection in immunocompetent patients.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1985.tb02409.x</identifier><identifier>PMID: 3913459</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acyclovir - administration & dosage ; Acyclovir - therapeutic use ; Administration, Oral ; Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Clinical Trials as Topic ; Double-Blind Method ; Female ; Herpes Simplex - prevention & control ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Recurrence</subject><ispartof>British journal of dermatology (1951), 1985-12, Vol.113 (6), p.731-735</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4601-7affd4ec9f3ac03f63ccdcc3bb9842a0fb0f596222098e415450dafd5526bf173</citedby><cites>FETCH-LOGICAL-c4601-7affd4ec9f3ac03f63ccdcc3bb9842a0fb0f596222098e415450dafd5526bf173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1985.tb02409.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1985.tb02409.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8507159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3913459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMAS, R.H.MEYRICK</creatorcontrib><creatorcontrib>DODD, H.J.</creatorcontrib><creatorcontrib>YEO, JANE M.</creatorcontrib><creatorcontrib>KIRBY, J.D.T.</creatorcontrib><title>Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>SUMMARY
In a double‐blind, placebo‐controlled, cross‐over trial in 11 patients suffering eight or more episodes of recurrent non‐genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, compared with nine during placebo treatment (P=0.016). Although lesion development was effectively suppressed in nine of the patients whilst taking acyclovir, the development of prodromal symptoms, and occasionally erythema, was reported by five. There was no difference between acyclovir and placebo in the time to the next recurrence following completion of treatment. No patient reported any side effects of either placebo or acyclovir therapy. It is believed that this is the first report of any form of oral therapy which is effective in suppressing recurrent non‐genital HSV infection in immunocompetent patients.</description><subject>Acyclovir - administration & dosage</subject><subject>Acyclovir - therapeutic use</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Herpes Simplex - prevention & control</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Herpes Simplex - prevention & control</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMAS, R.H.MEYRICK</creatorcontrib><creatorcontrib>DODD, H.J.</creatorcontrib><creatorcontrib>YEO, JANE M.</creatorcontrib><creatorcontrib>KIRBY, J.D.T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOMAS, R.H.MEYRICK</au><au>DODD, H.J.</au><au>YEO, JANE M.</au><au>KIRBY, J.D.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1985-12</date><risdate>1985</risdate><volume>113</volume><issue>6</issue><spage>731</spage><epage>735</epage><pages>731-735</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>SUMMARY
In a double‐blind, placebo‐controlled, cross‐over trial in 11 patients suffering eight or more episodes of recurrent non‐genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, compared with nine during placebo treatment (P=0.016). Although lesion development was effectively suppressed in nine of the patients whilst taking acyclovir, the development of prodromal symptoms, and occasionally erythema, was reported by five. There was no difference between acyclovir and placebo in the time to the next recurrence following completion of treatment. No patient reported any side effects of either placebo or acyclovir therapy. It is believed that this is the first report of any form of oral therapy which is effective in suppressing recurrent non‐genital HSV infection in immunocompetent patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3913459</pmid><doi>10.1111/j.1365-2133.1985.tb02409.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 1985-12, Vol.113 (6), p.731-735 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76614951 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acyclovir - administration & dosage Acyclovir - therapeutic use Administration, Oral Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Clinical Trials as Topic Double-Blind Method Female Herpes Simplex - prevention & control Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Recurrence |
| title | Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection |
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