Ligand motifs of HLA-DRB50101 and DRB11501 molecules delineated from self-peptides

Antigenic peptides are presented to CD4+ T cells by MHC class II molecules via a highly polymorphic peptide-binding groove. The two HLA-DR alleles isotypically expressed on HLA-DR15Dw2-positive cells, DRB1*1501 (DR2b) and DRB5*0101 (DR2a) molecules, show a number of differences in polymorphic residu...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-08, Vol.153 (4), p.1665-1673
Hauptverfasser:	Vogt, AB, Kropshofer, H, Kalbacher, H, Kalbus, M, Rammensee, HG, Coligan, JE, Martin, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Autoantigens - chemistry Autoantigens - immunology Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism HLA-DR Antigens - chemistry HLA-DR Antigens - genetics HLA-DR Antigens - metabolism HLA-DRB1 Chains HLA-DRB5 Chains Humans Ligands Molecular Sequence Data Myelin Basic Protein - immunology Peptides - immunology Protein Structure, Tertiary Sequence Alignment Structure-Activity Relationship
Online-Zugang:	Volltext
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