Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture

SUMMARY Azelaic acid has been shown clinically to have a cytotoxic effect on the abnormally active and malignant human melanocyte, but it has no apparent effect upon normal melanocytes. This difference in reactivity between normal and abnormal cells in vivo is further examined here in vitro. The dis...

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Veröffentlicht in:	British journal of dermatology (1951) 1985-12, Vol.113 (6), p.687-697
Hauptverfasser:	ROBINS, E.J., BREATHNACH, A.S., BENNETT, D., WARD, B.J., BHASIN, Y., ETHRIDGE, L., NAZZARO-PORRO, M., PASSI, S., PICARDO, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line Cells, Cultured Dermatology Dicarboxylic Acids - pharmacology Epidermis - ultrastructure Humans Infant, Newborn Medical sciences Melanocytes - drug effects Melanocytes - ultrastructure Melanoma - ultrastructure Microscopy, Electron Skin Neoplasms - ultrastructure Tumors of the skin and soft tissue. Premalignant lesions
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