Sensing Starvation: A Homoserine Lactone-Dependent Signaling Pathway in Escherichia coli

When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli, this process is mediated by the σ$^s$ subunit of RNA polymerase. Expression of σ$^s$ was induced by homoserine lactone, a metabolite synthesized from intermediates in thr...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-07, Vol.265 (5171), p.537-539
Hauptverfasser:	Huisman, Gjalt W., Kolter, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - metabolism 4-Butyrolactone - pharmacology Amino Acid Sequence Amino acids Bacteria Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Biosynthesis Catalase - metabolism Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genes Growth, nutrition, cell differenciation Lactones Microbiology Models, Biological Molecular Sequence Data Operon Phenotype Physiological aspects Plasmids Sigma Factor - biosynthesis Sigma Factor - genetics Signal Transduction Starvation Steepest descent method Streptomyces ambofaciens Transcription, Genetic Vibrio - genetics
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