A Revised Structure for the Disialosyl Globo-Series Gangliosides of Human Erythrocytes and Chicken Skeletal Muscle
Disialosyl globo-series gangliosides have previously been isolated from chicken skeletal muscle (E. L. Hogan, R. D. Happel, and J.-L. Chien (1982) Adv. Exp. Med. Biol. 152, 273-278; S. Dasgupta, J.-L. Chien, E. L. Hogan, and H. van Halbeek (1991) J. Lipid Res. 32, 499-506) and human erythrocytes (S....
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| Veröffentlicht in: | Archives of biochemistry and biophysics 1994-07, Vol.312 (1), p.125-134 |
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| creator | Levery, S.B. Salyan, M.E.K. Steele, S.J. Kannagi, R. Dasgupta, S. Chien, J.L. Hogan, E.L. Vanhalbeek, H. Hakomori, S. |
| description | Disialosyl globo-series gangliosides have previously been isolated from chicken skeletal muscle (E. L. Hogan, R. D. Happel, and J.-L. Chien (1982)
Adv. Exp. Med. Biol. 152, 273-278; S. Dasgupta, J.-L. Chien, E. L. Hogan, and H. van Halbeek (1991)
J. Lipid Res. 32, 499-506) and human erythrocytes (S. K. Kundu, B. E. Samuelsson, I. Pascher, and D. Marcus (1983)
J. Biol. Chem. 258, 13857-13866). In both cases, the structure of this ganglioside was proposed to be NeuAcα2 → 3(NeuAcα2 → 6)Galβ1 → 3GalNAcβ1 → 3Galα1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcV
6NeuAcGb
5Cer). We have reinvestigated the human erythrocyte antigen and now propose an alternative structure differing in the location of the NeuAcα2 → 6 residue: NeuAcα2 → 3Galβ1 → 3(NeuAcα2 → 6)GalNAcβ1 → 3Gal α1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcIV
6NeuAcGb
5Cer). This novel structure is supported by results of
1H-NMR spectroscopy, negative ion fast atom bombardment mass spectrometry, and methylation linkage analysis with capillary gas chromatography-mass spectrometry in both electron impact and chemical ionization modes. Furthermore, based on new results from negative ion fast atom bombardment mass spectrometry and linkage analysis, we propose that the chicken skeletal muscle antigen also has this revised structure, differing only in ceramide composition. The terminal tetrasaccharide of these gangliosides is identical to that of G
D1α NeuAcα2 → 3Galβ1 → 3(NeuAca2 → 6)GalNAcβ1 → 4Galβ1 → 4Glcβ1 → 1Cer(IV
3NeuAcIII
6NeuAcGg
4Cer), previously identified in a rat ascites hepatoma cell line (T. Taki, Y. Hirabayashi, H. Ishikawa, S. Ando, K. Ken, Y. Tanaka, and M. Matsumoto (1986)
J. Biol. Chem. 261, 3075-3078) and a murine lymphoma cell line with low metastatic potential (K. Murayama, S. B. Levery, V. Schirrmacher, and S. Hakomori (1986)
Cancer Res. 46, 1395-1402), although they appear to be immunologically distinct. |
| doi_str_mv | 10.1006/abbi.1994.1290 |
| format | Article |
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Adv. Exp. Med. Biol. 152, 273-278; S. Dasgupta, J.-L. Chien, E. L. Hogan, and H. van Halbeek (1991)
J. Lipid Res. 32, 499-506) and human erythrocytes (S. K. Kundu, B. E. Samuelsson, I. Pascher, and D. Marcus (1983)
J. Biol. Chem. 258, 13857-13866). In both cases, the structure of this ganglioside was proposed to be NeuAcα2 → 3(NeuAcα2 → 6)Galβ1 → 3GalNAcβ1 → 3Galα1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcV
6NeuAcGb
5Cer). We have reinvestigated the human erythrocyte antigen and now propose an alternative structure differing in the location of the NeuAcα2 → 6 residue: NeuAcα2 → 3Galβ1 → 3(NeuAcα2 → 6)GalNAcβ1 → 3Gal α1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcIV
6NeuAcGb
5Cer). This novel structure is supported by results of
1H-NMR spectroscopy, negative ion fast atom bombardment mass spectrometry, and methylation linkage analysis with capillary gas chromatography-mass spectrometry in both electron impact and chemical ionization modes. Furthermore, based on new results from negative ion fast atom bombardment mass spectrometry and linkage analysis, we propose that the chicken skeletal muscle antigen also has this revised structure, differing only in ceramide composition. The terminal tetrasaccharide of these gangliosides is identical to that of G
D1α NeuAcα2 → 3Galβ1 → 3(NeuAca2 → 6)GalNAcβ1 → 4Galβ1 → 4Glcβ1 → 1Cer(IV
3NeuAcIII
6NeuAcGg
4Cer), previously identified in a rat ascites hepatoma cell line (T. Taki, Y. Hirabayashi, H. Ishikawa, S. Ando, K. Ken, Y. Tanaka, and M. Matsumoto (1986)
J. Biol. Chem. 261, 3075-3078) and a murine lymphoma cell line with low metastatic potential (K. Murayama, S. B. Levery, V. Schirrmacher, and S. Hakomori (1986)
Cancer Res. 46, 1395-1402), although they appear to be immunologically distinct.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1006/abbi.1994.1290</identifier><identifier>PMID: 8031119</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carbohydrate Sequence ; Chickens ; Erythrocytes - chemistry ; Gangliosides - chemistry ; Gangliosides - classification ; Gangliosides - isolation & purification ; Glycosphingolipids - chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Sequence Data ; Muscles - chemistry ; Sequence Analysis ; Sialic Acids - chemistry ; Spectrometry, Mass, Fast Atom Bombardment</subject><ispartof>Archives of biochemistry and biophysics, 1994-07, Vol.312 (1), p.125-134</ispartof><rights>1994 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254t-3f2d84f52cba18414a84e5b40b3ff19595c74faebb764fc8d6b102ea2a5a4e123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003986184712902$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8031119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levery, S.B.</creatorcontrib><creatorcontrib>Salyan, M.E.K.</creatorcontrib><creatorcontrib>Steele, S.J.</creatorcontrib><creatorcontrib>Kannagi, R.</creatorcontrib><creatorcontrib>Dasgupta, S.</creatorcontrib><creatorcontrib>Chien, J.L.</creatorcontrib><creatorcontrib>Hogan, E.L.</creatorcontrib><creatorcontrib>Vanhalbeek, H.</creatorcontrib><creatorcontrib>Hakomori, S.</creatorcontrib><title>A Revised Structure for the Disialosyl Globo-Series Gangliosides of Human Erythrocytes and Chicken Skeletal Muscle</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>Disialosyl globo-series gangliosides have previously been isolated from chicken skeletal muscle (E. L. Hogan, R. D. Happel, and J.-L. Chien (1982)
Adv. Exp. Med. Biol. 152, 273-278; S. Dasgupta, J.-L. Chien, E. L. Hogan, and H. van Halbeek (1991)
J. Lipid Res. 32, 499-506) and human erythrocytes (S. K. Kundu, B. E. Samuelsson, I. Pascher, and D. Marcus (1983)
J. Biol. Chem. 258, 13857-13866). In both cases, the structure of this ganglioside was proposed to be NeuAcα2 → 3(NeuAcα2 → 6)Galβ1 → 3GalNAcβ1 → 3Galα1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcV
6NeuAcGb
5Cer). We have reinvestigated the human erythrocyte antigen and now propose an alternative structure differing in the location of the NeuAcα2 → 6 residue: NeuAcα2 → 3Galβ1 → 3(NeuAcα2 → 6)GalNAcβ1 → 3Gal α1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcIV
6NeuAcGb
5Cer). This novel structure is supported by results of
1H-NMR spectroscopy, negative ion fast atom bombardment mass spectrometry, and methylation linkage analysis with capillary gas chromatography-mass spectrometry in both electron impact and chemical ionization modes. Furthermore, based on new results from negative ion fast atom bombardment mass spectrometry and linkage analysis, we propose that the chicken skeletal muscle antigen also has this revised structure, differing only in ceramide composition. The terminal tetrasaccharide of these gangliosides is identical to that of G
D1α NeuAcα2 → 3Galβ1 → 3(NeuAca2 → 6)GalNAcβ1 → 4Galβ1 → 4Glcβ1 → 1Cer(IV
3NeuAcIII
6NeuAcGg
4Cer), previously identified in a rat ascites hepatoma cell line (T. Taki, Y. Hirabayashi, H. Ishikawa, S. Ando, K. Ken, Y. Tanaka, and M. Matsumoto (1986)
J. Biol. Chem. 261, 3075-3078) and a murine lymphoma cell line with low metastatic potential (K. Murayama, S. B. Levery, V. Schirrmacher, and S. Hakomori (1986)
Cancer Res. 46, 1395-1402), although they appear to be immunologically distinct.</description><subject>Animals</subject><subject>Carbohydrate Sequence</subject><subject>Chickens</subject><subject>Erythrocytes - chemistry</subject><subject>Gangliosides - chemistry</subject><subject>Gangliosides - classification</subject><subject>Gangliosides - isolation & purification</subject><subject>Glycosphingolipids - chemistry</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Molecular Sequence Data</subject><subject>Muscles - chemistry</subject><subject>Sequence Analysis</subject><subject>Sialic Acids - chemistry</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFPGzEQha0KRAP02huST9w29Xi9zu4RpRAqUSEROFu2d9wYnDW1vUj592yUqLeeRjPvzZPeR8h3YHNgTP7Qxvg5dJ2YA-_YFzID1smK1a04ITPGWF11rYSv5DznV8YAhORn5KxlNQB0M5Ju6BN--Iw9XZc02jImpC4mWjZIf_rsdYh5F-gqRBOrNSaPma708Cf4mH0_LdHR-3GrB3qbdmWTot2V6aqHni433r7hQNdvGLDoQH-P2Qa8JKdOh4zfjvOCvNzdPi_vq4fH1a_lzUNleSNKVTvet8I13BoNrQChW4GNEczUzkHXdI1dCKfRmIUUzra9NMA4aq4bLRB4fUGuD7nvKf4dMRe19dliCHrAOGa1kJJxCXIyzg9Gm2LOCZ16T36r004BU3vIag9Z7SGrPeTp4eqYPJot9v_sR6qT3h50nOp9eEwqW4-Dxd4ntEX10f8v-hM7VIyk</recordid><startdate>199407</startdate><enddate>199407</enddate><creator>Levery, S.B.</creator><creator>Salyan, M.E.K.</creator><creator>Steele, S.J.</creator><creator>Kannagi, R.</creator><creator>Dasgupta, S.</creator><creator>Chien, J.L.</creator><creator>Hogan, E.L.</creator><creator>Vanhalbeek, H.</creator><creator>Hakomori, S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199407</creationdate><title>A Revised Structure for the Disialosyl Globo-Series Gangliosides of Human Erythrocytes and Chicken Skeletal Muscle</title><author>Levery, S.B. ; Salyan, M.E.K. ; Steele, S.J. ; Kannagi, R. ; Dasgupta, S. ; Chien, J.L. ; Hogan, E.L. ; Vanhalbeek, H. ; Hakomori, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-3f2d84f52cba18414a84e5b40b3ff19595c74faebb764fc8d6b102ea2a5a4e123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Carbohydrate Sequence</topic><topic>Chickens</topic><topic>Erythrocytes - chemistry</topic><topic>Gangliosides - chemistry</topic><topic>Gangliosides - classification</topic><topic>Gangliosides - isolation & purification</topic><topic>Glycosphingolipids - chemistry</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecular Sequence Data</topic><topic>Muscles - chemistry</topic><topic>Sequence Analysis</topic><topic>Sialic Acids - chemistry</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levery, S.B.</creatorcontrib><creatorcontrib>Salyan, M.E.K.</creatorcontrib><creatorcontrib>Steele, S.J.</creatorcontrib><creatorcontrib>Kannagi, R.</creatorcontrib><creatorcontrib>Dasgupta, S.</creatorcontrib><creatorcontrib>Chien, J.L.</creatorcontrib><creatorcontrib>Hogan, E.L.</creatorcontrib><creatorcontrib>Vanhalbeek, H.</creatorcontrib><creatorcontrib>Hakomori, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levery, S.B.</au><au>Salyan, M.E.K.</au><au>Steele, S.J.</au><au>Kannagi, R.</au><au>Dasgupta, S.</au><au>Chien, J.L.</au><au>Hogan, E.L.</au><au>Vanhalbeek, H.</au><au>Hakomori, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Revised Structure for the Disialosyl Globo-Series Gangliosides of Human Erythrocytes and Chicken Skeletal Muscle</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1994-07</date><risdate>1994</risdate><volume>312</volume><issue>1</issue><spage>125</spage><epage>134</epage><pages>125-134</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>Disialosyl globo-series gangliosides have previously been isolated from chicken skeletal muscle (E. L. Hogan, R. D. Happel, and J.-L. Chien (1982)
Adv. Exp. Med. Biol. 152, 273-278; S. Dasgupta, J.-L. Chien, E. L. Hogan, and H. van Halbeek (1991)
J. Lipid Res. 32, 499-506) and human erythrocytes (S. K. Kundu, B. E. Samuelsson, I. Pascher, and D. Marcus (1983)
J. Biol. Chem. 258, 13857-13866). In both cases, the structure of this ganglioside was proposed to be NeuAcα2 → 3(NeuAcα2 → 6)Galβ1 → 3GalNAcβ1 → 3Galα1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcV
6NeuAcGb
5Cer). We have reinvestigated the human erythrocyte antigen and now propose an alternative structure differing in the location of the NeuAcα2 → 6 residue: NeuAcα2 → 3Galβ1 → 3(NeuAcα2 → 6)GalNAcβ1 → 3Gal α1 → 4Galβ1 → 4Glcβ1 → 1Cer (V
3NeuAcIV
6NeuAcGb
5Cer). This novel structure is supported by results of
1H-NMR spectroscopy, negative ion fast atom bombardment mass spectrometry, and methylation linkage analysis with capillary gas chromatography-mass spectrometry in both electron impact and chemical ionization modes. Furthermore, based on new results from negative ion fast atom bombardment mass spectrometry and linkage analysis, we propose that the chicken skeletal muscle antigen also has this revised structure, differing only in ceramide composition. The terminal tetrasaccharide of these gangliosides is identical to that of G
D1α NeuAcα2 → 3Galβ1 → 3(NeuAca2 → 6)GalNAcβ1 → 4Galβ1 → 4Glcβ1 → 1Cer(IV
3NeuAcIII
6NeuAcGg
4Cer), previously identified in a rat ascites hepatoma cell line (T. Taki, Y. Hirabayashi, H. Ishikawa, S. Ando, K. Ken, Y. Tanaka, and M. Matsumoto (1986)
J. Biol. Chem. 261, 3075-3078) and a murine lymphoma cell line with low metastatic potential (K. Murayama, S. B. Levery, V. Schirrmacher, and S. Hakomori (1986)
Cancer Res. 46, 1395-1402), although they appear to be immunologically distinct.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8031119</pmid><doi>10.1006/abbi.1994.1290</doi><tpages>10</tpages></addata></record> |
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| ispartof | Archives of biochemistry and biophysics, 1994-07, Vol.312 (1), p.125-134 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carbohydrate Sequence Chickens Erythrocytes - chemistry Gangliosides - chemistry Gangliosides - classification Gangliosides - isolation & purification Glycosphingolipids - chemistry Humans Magnetic Resonance Spectroscopy Molecular Sequence Data Muscles - chemistry Sequence Analysis Sialic Acids - chemistry Spectrometry, Mass, Fast Atom Bombardment |
| title | A Revised Structure for the Disialosyl Globo-Series Gangliosides of Human Erythrocytes and Chicken Skeletal Muscle |
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