Changes in the antioxidative defensive system during open heart operations in humans
It is known that reperfusion of the ischemic myocardium may intensify damage and increase the extent of myocardial necrosis. Oxygen free radicals and their metabolites have been implicated as possible elements in myocardial ischemia-reperfusion injury. In this study in cyanotic patients undergoing o...
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| Veröffentlicht in: | The Annals of thoracic surgery 1994-07, Vol.58 (1), p.170-175 |
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| creator | Kim, Ki-Bong Chung, Hyoung Hwa Kim, Myung Suk Rho, Joon Ryang |
| description | It is known that reperfusion of the ischemic myocardium may intensify damage and increase the extent of myocardial necrosis. Oxygen free radicals and their metabolites have been implicated as possible elements in myocardial ischemia-reperfusion injury. In this study in cyanotic patients undergoing open heart operation for tetralogy of Fallot, the myocardial tissue activities of catalase, superoxide dismutase, glutathione peroxidase, and lactate dehydrogenase were determined together with the tissue contents of malondialdehyde, oxidized glutathione, and total glutathione using the spectrophotometric assay method. The tissue activities of catalase, Superoxide dismutase, and glutathione peroxidase increased significantly after myocardial reperfusion (
p < 0.05) when compared with the tissue activities of the control group (myocardial tissue taken immediately after aortic crossclamping). The tissue content of malondialdehyde increased significantly after reperfusion (
p < 0.05), but the tissue activity of lactate dehydrogenase and the ratio of oxidized glutathione to total glutathione showed an insignificant difference after reperfusion. These data suggest that peroxidation of the cardiac lipids was triggered by the reperfusion of the hypoxic heart, but the myocardial cellular damage was not significant enough to decrease the myocardial lactate dehydrogenase and total glutathione levels. These results also suggest that oxygen free radicals may play an important role in in-vivo myocardial reperfusion stress, but endogenous self-defensive enzyme systems to protect the cell against the cytotoxic oxygen metabolites also were triggered, and the resulting myocardiat cellular damage was insignificant. |
| doi_str_mv | 10.1016/0003-4975(94)91094-4 |
| format | Article |
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p < 0.05) when compared with the tissue activities of the control group (myocardial tissue taken immediately after aortic crossclamping). The tissue content of malondialdehyde increased significantly after reperfusion (
p < 0.05), but the tissue activity of lactate dehydrogenase and the ratio of oxidized glutathione to total glutathione showed an insignificant difference after reperfusion. These data suggest that peroxidation of the cardiac lipids was triggered by the reperfusion of the hypoxic heart, but the myocardial cellular damage was not significant enough to decrease the myocardial lactate dehydrogenase and total glutathione levels. These results also suggest that oxygen free radicals may play an important role in in-vivo myocardial reperfusion stress, but endogenous self-defensive enzyme systems to protect the cell against the cytotoxic oxygen metabolites also were triggered, and the resulting myocardiat cellular damage was insignificant.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/0003-4975(94)91094-4</identifier><identifier>PMID: 8037518</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Catalase - metabolism ; Child, Preschool ; Female ; Free Radical Scavengers ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Humans ; L-Lactate Dehydrogenase - metabolism ; Male ; Malondialdehyde - metabolism ; Myocardial Reperfusion Injury - enzymology ; Myocardial Reperfusion Injury - etiology ; Myocardial Reperfusion Injury - prevention & control ; Myocardium - enzymology ; Reactive Oxygen Species ; Superoxide Dismutase - metabolism ; Tetralogy of Fallot - surgery</subject><ispartof>The Annals of thoracic surgery, 1994-07, Vol.58 (1), p.170-175</ispartof><rights>1994 The Society of Thoracic Surgeons</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-8573645321433c58808d025684bab1f2fdfa41a1d1d7ebe527f28ecea0fbba0c3</citedby><cites>FETCH-LOGICAL-c438t-8573645321433c58808d025684bab1f2fdfa41a1d1d7ebe527f28ecea0fbba0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8037518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ki-Bong</creatorcontrib><creatorcontrib>Chung, Hyoung Hwa</creatorcontrib><creatorcontrib>Kim, Myung Suk</creatorcontrib><creatorcontrib>Rho, Joon Ryang</creatorcontrib><title>Changes in the antioxidative defensive system during open heart operations in humans</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>It is known that reperfusion of the ischemic myocardium may intensify damage and increase the extent of myocardial necrosis. Oxygen free radicals and their metabolites have been implicated as possible elements in myocardial ischemia-reperfusion injury. In this study in cyanotic patients undergoing open heart operation for tetralogy of Fallot, the myocardial tissue activities of catalase, superoxide dismutase, glutathione peroxidase, and lactate dehydrogenase were determined together with the tissue contents of malondialdehyde, oxidized glutathione, and total glutathione using the spectrophotometric assay method. The tissue activities of catalase, Superoxide dismutase, and glutathione peroxidase increased significantly after myocardial reperfusion (
p < 0.05) when compared with the tissue activities of the control group (myocardial tissue taken immediately after aortic crossclamping). The tissue content of malondialdehyde increased significantly after reperfusion (
p < 0.05), but the tissue activity of lactate dehydrogenase and the ratio of oxidized glutathione to total glutathione showed an insignificant difference after reperfusion. These data suggest that peroxidation of the cardiac lipids was triggered by the reperfusion of the hypoxic heart, but the myocardial cellular damage was not significant enough to decrease the myocardial lactate dehydrogenase and total glutathione levels. These results also suggest that oxygen free radicals may play an important role in in-vivo myocardial reperfusion stress, but endogenous self-defensive enzyme systems to protect the cell against the cytotoxic oxygen metabolites also were triggered, and the resulting myocardiat cellular damage was insignificant.</description><subject>Catalase - metabolism</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Free Radical Scavengers</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Myocardial Reperfusion Injury - enzymology</subject><subject>Myocardial Reperfusion Injury - etiology</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Myocardium - enzymology</subject><subject>Reactive Oxygen Species</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tetralogy of Fallot - surgery</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EKqXwBiDlhOAQsGM7cS5IqOJPqsSlnC3HXrdGjVPspKJvT9JWPXLaXc3srPZD6JrgB4JJ_ogxpikrC35XsvuS4JKl7ASNCedZmme8PEXjo-UcXcT43Y9ZL4_QSGBacCLGaD5dKr-AmDiftEtIlG9d8-uMat0GEgMWfBy6uI0t1InpgvOLpFmDT5agQju0oTc3fhex7Grl4yU6s2oV4epQJ-jr9WU-fU9nn28f0-dZqhkVbSp4QXPGaUYYpZoLgYXBGc8Fq1RFbGaNVYwoYogpoAKeFTYToEFhW1UKazpBt_vcdWh-OoitrF3UsFopD00XZZHnGDNc9ka2N-rQxBjAynVwtQpbSbAcYMqBlBxIyZLJHUzJ-rWbQ35X1WCOSwd6vf6016F_cuMgyKgdeA3GBdCtNI37_8AfU5mEaQ</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Kim, Ki-Bong</creator><creator>Chung, Hyoung Hwa</creator><creator>Kim, Myung Suk</creator><creator>Rho, Joon Ryang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Changes in the antioxidative defensive system during open heart operations in humans</title><author>Kim, Ki-Bong ; Chung, Hyoung Hwa ; Kim, Myung Suk ; Rho, Joon Ryang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-8573645321433c58808d025684bab1f2fdfa41a1d1d7ebe527f28ecea0fbba0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Catalase - metabolism</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Free Radical Scavengers</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Humans</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Myocardial Reperfusion Injury - enzymology</topic><topic>Myocardial Reperfusion Injury - etiology</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Myocardium - enzymology</topic><topic>Reactive Oxygen Species</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Tetralogy of Fallot - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ki-Bong</creatorcontrib><creatorcontrib>Chung, Hyoung Hwa</creatorcontrib><creatorcontrib>Kim, Myung Suk</creatorcontrib><creatorcontrib>Rho, Joon Ryang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ki-Bong</au><au>Chung, Hyoung Hwa</au><au>Kim, Myung Suk</au><au>Rho, Joon Ryang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the antioxidative defensive system during open heart operations in humans</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>58</volume><issue>1</issue><spage>170</spage><epage>175</epage><pages>170-175</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>It is known that reperfusion of the ischemic myocardium may intensify damage and increase the extent of myocardial necrosis. Oxygen free radicals and their metabolites have been implicated as possible elements in myocardial ischemia-reperfusion injury. In this study in cyanotic patients undergoing open heart operation for tetralogy of Fallot, the myocardial tissue activities of catalase, superoxide dismutase, glutathione peroxidase, and lactate dehydrogenase were determined together with the tissue contents of malondialdehyde, oxidized glutathione, and total glutathione using the spectrophotometric assay method. The tissue activities of catalase, Superoxide dismutase, and glutathione peroxidase increased significantly after myocardial reperfusion (
p < 0.05) when compared with the tissue activities of the control group (myocardial tissue taken immediately after aortic crossclamping). The tissue content of malondialdehyde increased significantly after reperfusion (
p < 0.05), but the tissue activity of lactate dehydrogenase and the ratio of oxidized glutathione to total glutathione showed an insignificant difference after reperfusion. These data suggest that peroxidation of the cardiac lipids was triggered by the reperfusion of the hypoxic heart, but the myocardial cellular damage was not significant enough to decrease the myocardial lactate dehydrogenase and total glutathione levels. These results also suggest that oxygen free radicals may play an important role in in-vivo myocardial reperfusion stress, but endogenous self-defensive enzyme systems to protect the cell against the cytotoxic oxygen metabolites also were triggered, and the resulting myocardiat cellular damage was insignificant.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>8037518</pmid><doi>10.1016/0003-4975(94)91094-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Catalase - metabolism Child, Preschool Female Free Radical Scavengers Glutathione - metabolism Glutathione Peroxidase - metabolism Humans L-Lactate Dehydrogenase - metabolism Male Malondialdehyde - metabolism Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Reactive Oxygen Species Superoxide Dismutase - metabolism Tetralogy of Fallot - surgery |
| title | Changes in the antioxidative defensive system during open heart operations in humans |
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