Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations

In breast cancer, loss of heterozygosity (LOH) on 17p is a frequent event and a likely target is the p53 gene on 17p13.1. However, several LOH mapping studies have indicated that, in some breast tumors, LOH affects only the most distal 17p markers, suggestive of a second tumor suppressor locus in 17...

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