Taurine supplementation at three different dosages and its effect on trauma patients

We studied the effect of different amounts of intravenous taurine supplementation on restoring serum taurine concentrations in trauma patients. The nature of the hypotaurinemia in trauma patients was also studied by following renal-clearance dynamics. Five trauma patients in each of four groups were...

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Veröffentlicht in:The American journal of clinical nutrition 1994-08, Vol.60 (2), p.203-206
Hauptverfasser: Paauw, JD, Davis, AT
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Davis, AT
description We studied the effect of different amounts of intravenous taurine supplementation on restoring serum taurine concentrations in trauma patients. The nature of the hypotaurinemia in trauma patients was also studied by following renal-clearance dynamics. Five trauma patients in each of four groups were randomly assigned to receive, in their parenteral nutrition solutions, one of three dosages of taurine (5, 10.8, or 50 mg/kg ideal body wt as group 1, 2, or 3, respectively) or no taurine. Serum taurine concentrations rose significantly over 7 d, relative to control values, in both groups 2 and 3, but even with the highest dosage (group 3) only recovered about one-half of the deficit to the normal value. Despite low serum taurine concentrations in group 3, in contrast with handling of other amino acids, tubular reabsorption of taurine remained abnormally low after 7 d, resulting in a large taurine excretion. Hypotaurinemia in trauma patients persists longer than other hypoaminoacidemias because of depressed renal tubular reabsorption. Even 7 d of a high-dose taurine supplementation does not fully correct the hypotaurinemia of trauma.
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subjects Adolescent
Adult
Aged
Amino acids
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
cholestasis
Cysteine - blood
Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition
Female
Humans
Injuries
Intensive care medicine
kidney tubules
Kidney Tubules - metabolism
Male
Medical research
Medical sciences
Metabolic Clearance Rate
Methionine - blood
Middle Aged
Parenteral Nutrition
Taurine
Taurine - administration & dosage
Taurine - blood
Taurine - urine
trauma
Wounds and Injuries - blood
title Taurine supplementation at three different dosages and its effect on trauma patients
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