The use of vaginal tablets as a vehicle for steroid replacement in a donor oocyte program
Nine women enrolled in the donor egg program received in a preparatory cycle 6 mg of E2 by vaginal tablets two times per day for the first 14 days, followed by a combined preparation of 6 mg of E2 and 50 mg of P as vaginal tablets, two times per day for another 14 days. Adequate serum levels of E2 a...
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| Veröffentlicht in: | Fertility and sterility 1994-08, Vol.62 (2), p.412-414 |
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| container_title | Fertility and sterility |
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| creator | Shushan, Asher Simon, Alex Reubinoff, Benjamin E. Lewin, Aby Schenker, Joseph G. Laufer, Neri |
| description | Nine women enrolled in the donor egg program received in a preparatory cycle 6 mg of E2 by vaginal tablets two times per day for the first 14 days, followed by a combined preparation of 6 mg of E2 and 50 mg of P as vaginal tablets, two times per day for another 14 days. Adequate serum levels of E2 and P and favorable sonographic endometrial thickness were achieved throughout the cycle in all patients. Eight endometrial biopsies taken on days 25 to 26 were independently assessed as being representative of day 25 +/- 2. One endometrial biopsy was out of phase. It is concluded that vaginal tablets of E2, followed by a combined preparation of vaginal tablets of E2 and P, is an effective method for establishing an appropriately developed endometrium in a donor oocyte program. Endometrial preparation in donor oocyte programs can be simplified by the use of these tablets. |
| doi_str_mv | 10.1016/S0015-0282(16)56900-3 |
| format | Article |
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Adequate serum levels of E2 and P and favorable sonographic endometrial thickness were achieved throughout the cycle in all patients. Eight endometrial biopsies taken on days 25 to 26 were independently assessed as being representative of day 25 +/- 2. One endometrial biopsy was out of phase. It is concluded that vaginal tablets of E2, followed by a combined preparation of vaginal tablets of E2 and P, is an effective method for establishing an appropriately developed endometrium in a donor oocyte program. Endometrial preparation in donor oocyte programs can be simplified by the use of these tablets.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)56900-3</identifier><identifier>PMID: 8034094</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biopsy ; Drug Combinations ; Egg donation ; Endometrium - pathology ; Estradiol - administration & dosage ; Estradiol - blood ; Estradiol - pharmacology ; Female ; hormone replacement therapy ; Hormones. Endocrine system ; Humans ; Luteal Phase ; Medical sciences ; mock cycle ; Oocytes ; Pessaries ; Pharmacology. Drug treatments ; Progesterone - administration & dosage ; Progesterone - blood ; Progesterone - pharmacology ; Tissue Donors ; vaginal tablet</subject><ispartof>Fertility and sterility, 1994-08, Vol.62 (2), p.412-414</ispartof><rights>1994 American Society for Reproductive Medicine</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-3ed8679676ef16e37c1b0b2ba73bb5a1701dda113d67bf0be884cbb965b5aee53</citedby><cites>FETCH-LOGICAL-c436t-3ed8679676ef16e37c1b0b2ba73bb5a1701dda113d67bf0be884cbb965b5aee53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)56900-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4242055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8034094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shushan, Asher</creatorcontrib><creatorcontrib>Simon, Alex</creatorcontrib><creatorcontrib>Reubinoff, Benjamin E.</creatorcontrib><creatorcontrib>Lewin, Aby</creatorcontrib><creatorcontrib>Schenker, Joseph G.</creatorcontrib><creatorcontrib>Laufer, Neri</creatorcontrib><title>The use of vaginal tablets as a vehicle for steroid replacement in a donor oocyte program</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Nine women enrolled in the donor egg program received in a preparatory cycle 6 mg of E2 by vaginal tablets two times per day for the first 14 days, followed by a combined preparation of 6 mg of E2 and 50 mg of P as vaginal tablets, two times per day for another 14 days. Adequate serum levels of E2 and P and favorable sonographic endometrial thickness were achieved throughout the cycle in all patients. Eight endometrial biopsies taken on days 25 to 26 were independently assessed as being representative of day 25 +/- 2. One endometrial biopsy was out of phase. It is concluded that vaginal tablets of E2, followed by a combined preparation of vaginal tablets of E2 and P, is an effective method for establishing an appropriately developed endometrium in a donor oocyte program. Endometrial preparation in donor oocyte programs can be simplified by the use of these tablets.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Drug Combinations</subject><subject>Egg donation</subject><subject>Endometrium - pathology</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - blood</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>hormone replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Luteal Phase</subject><subject>Medical sciences</subject><subject>mock cycle</subject><subject>Oocytes</subject><subject>Pessaries</subject><subject>Pharmacology. Drug treatments</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - blood</subject><subject>Progesterone - pharmacology</subject><subject>Tissue Donors</subject><subject>vaginal tablet</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoSTeb_oSADqU0Bzcjy5LsUymhbQILOSQ59CT0MU4UbGsreRfy76PNLnstDIjhfUYzPIRcMPjOgMmrewAmKqjb-huTl0J2ABU_IQsmhKyEFPwDWRyRT-Qs5xcAkEzVp-S0Bd5A1yzI34dnpJuMNPZ0a57CZAY6GzvgnKkpRbf4HNyAtI-J5hlTDJ4mXA_G4YjTTMNUIB-nEsfoXmek6xSfkhnPycfeDBk_H94lefz96-H6plrd_bm9_rmqXMPlXHH0rVSdVBJ7JpErxyzY2hrFrRWGKWDeG8a4l8r2YLFtG2dtJ0VJEQVfkq_7f8vefxvMsx5DdjgMZsK4yVpJ0XFoVQHFHnQp5pyw1-sURpNeNQO9U6rfleqdL126d6Wal7mLw4KNHdEfpw4OS_7lkJvszNAnM7mQj1hTNzWI3Z0_9hgWGduASWcXcHLoQ0I3ax_Dfw55A3VUktQ</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>Shushan, Asher</creator><creator>Simon, Alex</creator><creator>Reubinoff, Benjamin E.</creator><creator>Lewin, Aby</creator><creator>Schenker, Joseph G.</creator><creator>Laufer, Neri</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940801</creationdate><title>The use of vaginal tablets as a vehicle for steroid replacement in a donor oocyte program</title><author>Shushan, Asher ; Simon, Alex ; Reubinoff, Benjamin E. ; Lewin, Aby ; Schenker, Joseph G. ; Laufer, Neri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-3ed8679676ef16e37c1b0b2ba73bb5a1701dda113d67bf0be884cbb965b5aee53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Drug Combinations</topic><topic>Egg donation</topic><topic>Endometrium - pathology</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - blood</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>hormone replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Luteal Phase</topic><topic>Medical sciences</topic><topic>mock cycle</topic><topic>Oocytes</topic><topic>Pessaries</topic><topic>Pharmacology. Drug treatments</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - blood</topic><topic>Progesterone - pharmacology</topic><topic>Tissue Donors</topic><topic>vaginal tablet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shushan, Asher</creatorcontrib><creatorcontrib>Simon, Alex</creatorcontrib><creatorcontrib>Reubinoff, Benjamin E.</creatorcontrib><creatorcontrib>Lewin, Aby</creatorcontrib><creatorcontrib>Schenker, Joseph G.</creatorcontrib><creatorcontrib>Laufer, Neri</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shushan, Asher</au><au>Simon, Alex</au><au>Reubinoff, Benjamin E.</au><au>Lewin, Aby</au><au>Schenker, Joseph G.</au><au>Laufer, Neri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of vaginal tablets as a vehicle for steroid replacement in a donor oocyte program</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>62</volume><issue>2</issue><spage>412</spage><epage>414</epage><pages>412-414</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Nine women enrolled in the donor egg program received in a preparatory cycle 6 mg of E2 by vaginal tablets two times per day for the first 14 days, followed by a combined preparation of 6 mg of E2 and 50 mg of P as vaginal tablets, two times per day for another 14 days. Adequate serum levels of E2 and P and favorable sonographic endometrial thickness were achieved throughout the cycle in all patients. Eight endometrial biopsies taken on days 25 to 26 were independently assessed as being representative of day 25 +/- 2. One endometrial biopsy was out of phase. It is concluded that vaginal tablets of E2, followed by a combined preparation of vaginal tablets of E2 and P, is an effective method for establishing an appropriately developed endometrium in a donor oocyte program. Endometrial preparation in donor oocyte programs can be simplified by the use of these tablets.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8034094</pmid><doi>10.1016/S0015-0282(16)56900-3</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 1994-08, Vol.62 (2), p.412-414 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biopsy Drug Combinations Egg donation Endometrium - pathology Estradiol - administration & dosage Estradiol - blood Estradiol - pharmacology Female hormone replacement therapy Hormones. Endocrine system Humans Luteal Phase Medical sciences mock cycle Oocytes Pessaries Pharmacology. Drug treatments Progesterone - administration & dosage Progesterone - blood Progesterone - pharmacology Tissue Donors vaginal tablet |
| title | The use of vaginal tablets as a vehicle for steroid replacement in a donor oocyte program |
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