Wild-type but not mutant APC associates with the microtubule cytoskeleton

The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant forms of APC were expressed in...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-07, Vol.54 (14), p.3672-3675
Hauptverfasser:	SMITH, K. J, LEVY, D. B, MAUPIN, P, POLLARD, T. D, VOGELSTEIN, B, KINZLER, K. W
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adenomatous Polyposis Coli Protein Animals Biological and medical sciences Cytoskeletal Proteins - analysis Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Mice Microtubule Proteins - analysis Microtubules - chemistry Mutation Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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