Iloprost attenuates trauma-related pulmonary sequestration of leucocytes and platelets
The purpose of this study was to investigate the effects of iloprost, a synthetic prostacyclin analogue, on the pulmonary cellular trapping after a standardized soft tissue trauma. In two groups 1 and 2 iloprost was given in doses of 100 ng/kg/min commencing 30 and 20 min respectively prior to traum...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1994-04, Vol.50 (4), p.203-210 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Malmros, C. Blomquist, S. Mårtensson, L. Thörne, J. |
| description | The purpose of this study was to investigate the effects of iloprost, a synthetic prostacyclin analogue, on the pulmonary cellular trapping after a standardized soft tissue trauma. In two groups 1 and 2 iloprost was given in doses of 100 ng/kg/min commencing 30 and 20 min respectively prior to trauma and ceasing 10 min after trauma.
111Indium-oxine was used to label neutrophils in 6 animals from each group. Platelets were labelled in 6 and 7 animals respectively. A third group of 11 pigs served as a control and did not receive iloprost. The pulmonary sequestration of platelets and neutrophils was studied dynamically with a gamma camera and directly after trauma was significantly less in group 1 when compared to the control group. A rise in pulmonary vascular resistance and pulmonary arterial pressure was seen in the control group immediately after trauma but this was not evident in the iloprost groups. PaO
2 decreased significantly in group 1 and 2 during the iloprost infusion. The results indicate that iloprost attenuates the pulmonary cellular sequestration and changes in central hemodynamics during trauma in this model. |
| doi_str_mv | 10.1016/0952-3278(94)90146-5 |
| format | Article |
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111Indium-oxine was used to label neutrophils in 6 animals from each group. Platelets were labelled in 6 and 7 animals respectively. A third group of 11 pigs served as a control and did not receive iloprost. The pulmonary sequestration of platelets and neutrophils was studied dynamically with a gamma camera and directly after trauma was significantly less in group 1 when compared to the control group. A rise in pulmonary vascular resistance and pulmonary arterial pressure was seen in the control group immediately after trauma but this was not evident in the iloprost groups. PaO
2 decreased significantly in group 1 and 2 during the iloprost infusion. The results indicate that iloprost attenuates the pulmonary cellular sequestration and changes in central hemodynamics during trauma in this model.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/0952-3278(94)90146-5</identifier><identifier>PMID: 7517566</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Platelets - physiology ; Blood Pressure - drug effects ; Hormones. Endocrine system ; Iloprost - pharmacology ; Indium Radioisotopes ; Kinetics ; Leukocytes - physiology ; Lung - blood supply ; Lung - pathology ; Lung Injury ; Medical sciences ; Neutrophils - physiology ; Pharmacology. Drug treatments ; Pulmonary Artery - physiopathology ; Swine ; Vascular Resistance - drug effects</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 1994-04, Vol.50 (4), p.203-210</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-9dd032b9a53d5e7c82aa83c53ac15a23a1c54d0504444240e55413c5a13c029b3</citedby><cites>FETCH-LOGICAL-c332t-9dd032b9a53d5e7c82aa83c53ac15a23a1c54d0504444240e55413c5a13c029b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0952327894901465$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3987541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7517566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malmros, C.</creatorcontrib><creatorcontrib>Blomquist, S.</creatorcontrib><creatorcontrib>Mårtensson, L.</creatorcontrib><creatorcontrib>Thörne, J.</creatorcontrib><title>Iloprost attenuates trauma-related pulmonary sequestration of leucocytes and platelets</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>The purpose of this study was to investigate the effects of iloprost, a synthetic prostacyclin analogue, on the pulmonary cellular trapping after a standardized soft tissue trauma. In two groups 1 and 2 iloprost was given in doses of 100 ng/kg/min commencing 30 and 20 min respectively prior to trauma and ceasing 10 min after trauma.
111Indium-oxine was used to label neutrophils in 6 animals from each group. Platelets were labelled in 6 and 7 animals respectively. A third group of 11 pigs served as a control and did not receive iloprost. The pulmonary sequestration of platelets and neutrophils was studied dynamically with a gamma camera and directly after trauma was significantly less in group 1 when compared to the control group. A rise in pulmonary vascular resistance and pulmonary arterial pressure was seen in the control group immediately after trauma but this was not evident in the iloprost groups. PaO
2 decreased significantly in group 1 and 2 during the iloprost infusion. The results indicate that iloprost attenuates the pulmonary cellular sequestration and changes in central hemodynamics during trauma in this model.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - physiology</subject><subject>Blood Pressure - drug effects</subject><subject>Hormones. Endocrine system</subject><subject>Iloprost - pharmacology</subject><subject>Indium Radioisotopes</subject><subject>Kinetics</subject><subject>Leukocytes - physiology</subject><subject>Lung - blood supply</subject><subject>Lung - pathology</subject><subject>Lung Injury</subject><subject>Medical sciences</subject><subject>Neutrophils - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Artery - physiopathology</subject><subject>Swine</subject><subject>Vascular Resistance - drug effects</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1L7DAUhoMoOnf0Hyh0IeJdVPPZJhtBBu9VENyo23AmPQOVtB2TVPDfmzrDLDWLhPA-53DOQ8gpo1eMsuqaGsVLwWt9aeRfQ5msSrVHZkwJXnLNxT6Z7ZAj8ifGN0opZ0weksNasVpV1Yy8PvhhHYaYCkgJ-xESxiIFGDsoA_r8bYr16Luhh_BZRHwfMeY4tUNfDKvC4-gG9zkVQZ_JqcBjisfkYAU-4sn2nZOXf3fPi_vy8en_w-L2sXRC8FSapqGCLw0o0SisneYAWjglwDEFXABzSjZUUZkPlxSVkiznkC_KzVLMycWmb97hezTbtdGh99DjMEZbV0prnZX8BrKqNkZLnkG5AV22EgOu7Dq0XV7eMmon73aSaiep1kj77d1O_c-2_cdlh82uaCs65-fbHKIDvwrQuzbuMGF0Pa02JzcbDLO0jxaDja7F3mHTBnTJNkP78xxf_1KfMA</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Malmros, C.</creator><creator>Blomquist, S.</creator><creator>Mårtensson, L.</creator><creator>Thörne, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199404</creationdate><title>Iloprost attenuates trauma-related pulmonary sequestration of leucocytes and platelets</title><author>Malmros, C. ; Blomquist, S. ; Mårtensson, L. ; Thörne, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-9dd032b9a53d5e7c82aa83c53ac15a23a1c54d0504444240e55413c5a13c029b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - physiology</topic><topic>Blood Pressure - drug effects</topic><topic>Hormones. Endocrine system</topic><topic>Iloprost - pharmacology</topic><topic>Indium Radioisotopes</topic><topic>Kinetics</topic><topic>Leukocytes - physiology</topic><topic>Lung - blood supply</topic><topic>Lung - pathology</topic><topic>Lung Injury</topic><topic>Medical sciences</topic><topic>Neutrophils - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Swine</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malmros, C.</creatorcontrib><creatorcontrib>Blomquist, S.</creatorcontrib><creatorcontrib>Mårtensson, L.</creatorcontrib><creatorcontrib>Thörne, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malmros, C.</au><au>Blomquist, S.</au><au>Mårtensson, L.</au><au>Thörne, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iloprost attenuates trauma-related pulmonary sequestration of leucocytes and platelets</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>1994-04</date><risdate>1994</risdate><volume>50</volume><issue>4</issue><spage>203</spage><epage>210</epage><pages>203-210</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>The purpose of this study was to investigate the effects of iloprost, a synthetic prostacyclin analogue, on the pulmonary cellular trapping after a standardized soft tissue trauma. In two groups 1 and 2 iloprost was given in doses of 100 ng/kg/min commencing 30 and 20 min respectively prior to trauma and ceasing 10 min after trauma.
111Indium-oxine was used to label neutrophils in 6 animals from each group. Platelets were labelled in 6 and 7 animals respectively. A third group of 11 pigs served as a control and did not receive iloprost. The pulmonary sequestration of platelets and neutrophils was studied dynamically with a gamma camera and directly after trauma was significantly less in group 1 when compared to the control group. A rise in pulmonary vascular resistance and pulmonary arterial pressure was seen in the control group immediately after trauma but this was not evident in the iloprost groups. PaO
2 decreased significantly in group 1 and 2 during the iloprost infusion. The results indicate that iloprost attenuates the pulmonary cellular sequestration and changes in central hemodynamics during trauma in this model.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>7517566</pmid><doi>10.1016/0952-3278(94)90146-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 1994-04, Vol.50 (4), p.203-210 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Blood Platelets - physiology Blood Pressure - drug effects Hormones. Endocrine system Iloprost - pharmacology Indium Radioisotopes Kinetics Leukocytes - physiology Lung - blood supply Lung - pathology Lung Injury Medical sciences Neutrophils - physiology Pharmacology. Drug treatments Pulmonary Artery - physiopathology Swine Vascular Resistance - drug effects |
| title | Iloprost attenuates trauma-related pulmonary sequestration of leucocytes and platelets |
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