Antisense oligonucleotide complementary to endogenous retroviral MCF env gene inhibits both BFU-E and CFU-S colony formation in mice

A possible biologic activity of endogenously expressed env sequence of retroviral mink cell focus-forming virus (MCF) genome for hematopoietic colony formation was studied in mice. Antisense 20-mer complementary to MCF env sequence was used to detect the result of blockage of this gene translation o...

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Veröffentlicht in:	FEBS letters 1994-07, Vol.348 (2), p.197-200
Hauptverfasser:	Chernukhin, Igor V., Khaldoyanidi, Sophia K., Dikovskaya, Dina V., Svinarchuk, Feodor P., Vlasov, Valentin V., Gaidul, Konstantin V.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Antisense oligonucleotide Base Sequence BFU-E BFU-E, erythroid burst-forming unit Cell Division - drug effects Cells, Cultured CFU-GM CFU-GM, granulocyte-macrophage colony-forming unit CFU-S CFU-S, spleen colony-forming unit Colony-Forming Units Assay Endogenous retroviral sequences Epo, erythropoietin Genes, env Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Male MCF gene MCF, mink cell focus-forming virus Mice Mice, Inbred C57BL Mink Cell Focus-Inducing Viruses - genetics Molecular Sequence Data Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - pharmacology SU, surface glycoprotein TM, transmembrane protein
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