Shigellosis in neonates and young infants
To determine the clinical features and outcome of shigellosis in young infants, we reviewed the hospital records of 159 infants ≤ 3 months of age (including 30 neonates) and 159 children 1 to 10 years of age with shigellosis who were admitted to the Diarrhoea Treatment Centre in Dacca, Bangladesh. I...
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| Veröffentlicht in: | The Journal of pediatrics 1994-07, Vol.125 (1), p.14-22 |
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| creator | Huskins, W.Charles Griffiths, Jeffrey K. Faruque, A.S.G. Bennish, Michael L. |
| description | To determine the clinical features and outcome of shigellosis in young infants, we reviewed the hospital records of 159 infants ≤ 3 months of age (including 30 neonates) and 159 children 1 to 10 years of age with shigellosis who were admitted to the Diarrhoea Treatment Centre in Dacca, Bangladesh. Infants more commonly had a history of nonbloody diarrhea (82.8% vs 42.7%;
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| doi_str_mv | 10.1016/S0022-3476(94)70115-6 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76587505</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347694701156</els_id><sourcerecordid>76587505</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-c5b7da3c25bf747090c5d175c60e6cf4e77979bb90007085938f951694e69c383</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMotVZ_QmEPIvawOtnNx-YkUvyCgofqOWSz2RrZZmuyK_Tfm7ZLr54GMs_MvHkQmmK4w4DZ_RIgy9KccHYryIwDxjRlJ2iMQfCUFXl-isZH5BxdhPANAIIAjNCogAxzRsZotvyyK9M0bbAhsS5xpnWqMyFRrkq2be9W8bVWrguX6KxWTTBXQ52gz-enj_lrunh_eZs_LlKdF6JLNS15pXKd0bLmhIMATSvMqWZgmK6J4VxwUZYihuFQUJEXtaCYCWKYiCvyCbo57N349qc3oZNrG3SMqGK2PkjOaMEp0AjSA6h9G4I3tdx4u1Z-KzHInSK5VyR3_5eCyL0iyeLcdDjQl2tTHacGJ7F_PfRV0KqpvXLahiNGcGSyHfZwwEyU8WuNl0Fb47SprDe6k1Vr_wnyB1hRgDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76587505</pqid></control><display><type>article</type><title>Shigellosis in neonates and young infants</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Huskins, W.Charles ; Griffiths, Jeffrey K. ; Faruque, A.S.G. ; Bennish, Michael L.</creator><creatorcontrib>Huskins, W.Charles ; Griffiths, Jeffrey K. ; Faruque, A.S.G. ; Bennish, Michael L.</creatorcontrib><description><![CDATA[To determine the clinical features and outcome of shigellosis in young infants, we reviewed the hospital records of 159 infants ≤ 3 months of age (including 30 neonates) and 159 children 1 to 10 years of age with shigellosis who were admitted to the Diarrhoea Treatment Centre in Dacca, Bangladesh. Infants more commonly had a history of nonbloody diarrhea (82.8% vs 42.7%;
p <0.001), moderate or severe dehydration (59.9% vs 32.1%;
p <0.001), or bacteremia (12.0% vs 5.0%;
p = 0.027) and less commonly had fever (32.7% vs 58.6%;
p <0.001), abdominal tenderness (1.9% vs 12.6%;
p <0.001), or rectal prolapse (0% vs 8.3%;
p = 0.001). Infections caused by
Shigella boydii (20.8% vs 6.3%;
p <0.001) and
Shigella sonnei (7.5% vs 1.3%;
p = 0.006) were more common, and
Shigella dysenteriae type 1 (9.4% vs 31.4%;
p <0.001) infections were less common in infants than in older children; the proportion of
Shigella flexneri infections was equivalent in the two groups (59.1% vs 60.4%). Infants were twice as likely to die as older children (16.4% vs 8.2%;
p = 0.026). Only 17 infants (14.3%) were being exclusively breast fed at the onset of their illness. In a multiple logistic regression analysis, independent predictors of death in infants were gram-negative bacteremia, ileus, decreased bowel sounds, hyponatremia, hypoproteinemia, and a lower number of erythrocytes detected on microscopic examination of stool specimens. Diarrhea management algorithms that rely only on clinical findings of dysentery to diagnose and treat shigellosis are likely to be unreliable in this high-risk age group. (J P
EDIATR 1994;125:14-22)]]></description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(94)70115-6</identifier><identifier>PMID: 8021764</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Age Factors ; Bacterial diseases ; Biological and medical sciences ; Child ; Child, Preschool ; Diarrhea - complications ; Diarrhea - diagnosis ; Diarrhea - microbiology ; Diarrhea - mortality ; Diarrhea, Infantile - complications ; Diarrhea, Infantile - diagnosis ; Diarrhea, Infantile - microbiology ; Diarrhea, Infantile - mortality ; Dysentery, Bacillary - complications ; Dysentery, Bacillary - diagnosis ; Dysentery, Bacillary - mortality ; Female ; Human bacterial diseases ; Humans ; Infant ; Infant, Newborn ; Infectious diseases ; Logistic Models ; Male ; Medical sciences ; Miscellaneous ; Population ; Shigella - isolation & purification ; Tropical bacterial diseases ; Tropical medicine</subject><ispartof>The Journal of pediatrics, 1994-07, Vol.125 (1), p.14-22</ispartof><rights>1994 Mosby, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-c5b7da3c25bf747090c5d175c60e6cf4e77979bb90007085938f951694e69c383</citedby><cites>FETCH-LOGICAL-c389t-c5b7da3c25bf747090c5d175c60e6cf4e77979bb90007085938f951694e69c383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(94)70115-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4164324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8021764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huskins, W.Charles</creatorcontrib><creatorcontrib>Griffiths, Jeffrey K.</creatorcontrib><creatorcontrib>Faruque, A.S.G.</creatorcontrib><creatorcontrib>Bennish, Michael L.</creatorcontrib><title>Shigellosis in neonates and young infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description><![CDATA[To determine the clinical features and outcome of shigellosis in young infants, we reviewed the hospital records of 159 infants ≤ 3 months of age (including 30 neonates) and 159 children 1 to 10 years of age with shigellosis who were admitted to the Diarrhoea Treatment Centre in Dacca, Bangladesh. Infants more commonly had a history of nonbloody diarrhea (82.8% vs 42.7%;
p <0.001), moderate or severe dehydration (59.9% vs 32.1%;
p <0.001), or bacteremia (12.0% vs 5.0%;
p = 0.027) and less commonly had fever (32.7% vs 58.6%;
p <0.001), abdominal tenderness (1.9% vs 12.6%;
p <0.001), or rectal prolapse (0% vs 8.3%;
p = 0.001). Infections caused by
Shigella boydii (20.8% vs 6.3%;
p <0.001) and
Shigella sonnei (7.5% vs 1.3%;
p = 0.006) were more common, and
Shigella dysenteriae type 1 (9.4% vs 31.4%;
p <0.001) infections were less common in infants than in older children; the proportion of
Shigella flexneri infections was equivalent in the two groups (59.1% vs 60.4%). Infants were twice as likely to die as older children (16.4% vs 8.2%;
p = 0.026). Only 17 infants (14.3%) were being exclusively breast fed at the onset of their illness. In a multiple logistic regression analysis, independent predictors of death in infants were gram-negative bacteremia, ileus, decreased bowel sounds, hyponatremia, hypoproteinemia, and a lower number of erythrocytes detected on microscopic examination of stool specimens. Diarrhea management algorithms that rely only on clinical findings of dysentery to diagnose and treat shigellosis are likely to be unreliable in this high-risk age group. (J P
EDIATR 1994;125:14-22)]]></description><subject>Age Factors</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diarrhea - complications</subject><subject>Diarrhea - diagnosis</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - mortality</subject><subject>Diarrhea, Infantile - complications</subject><subject>Diarrhea, Infantile - diagnosis</subject><subject>Diarrhea, Infantile - microbiology</subject><subject>Diarrhea, Infantile - mortality</subject><subject>Dysentery, Bacillary - complications</subject><subject>Dysentery, Bacillary - diagnosis</subject><subject>Dysentery, Bacillary - mortality</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Population</subject><subject>Shigella - isolation & purification</subject><subject>Tropical bacterial diseases</subject><subject>Tropical medicine</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZ_QmEPIvawOtnNx-YkUvyCgofqOWSz2RrZZmuyK_Tfm7ZLr54GMs_MvHkQmmK4w4DZ_RIgy9KccHYryIwDxjRlJ2iMQfCUFXl-isZH5BxdhPANAIIAjNCogAxzRsZotvyyK9M0bbAhsS5xpnWqMyFRrkq2be9W8bVWrguX6KxWTTBXQ52gz-enj_lrunh_eZs_LlKdF6JLNS15pXKd0bLmhIMATSvMqWZgmK6J4VxwUZYihuFQUJEXtaCYCWKYiCvyCbo57N349qc3oZNrG3SMqGK2PkjOaMEp0AjSA6h9G4I3tdx4u1Z-KzHInSK5VyR3_5eCyL0iyeLcdDjQl2tTHacGJ7F_PfRV0KqpvXLahiNGcGSyHfZwwEyU8WuNl0Fb47SprDe6k1Vr_wnyB1hRgDw</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Huskins, W.Charles</creator><creator>Griffiths, Jeffrey K.</creator><creator>Faruque, A.S.G.</creator><creator>Bennish, Michael L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Shigellosis in neonates and young infants</title><author>Huskins, W.Charles ; Griffiths, Jeffrey K. ; Faruque, A.S.G. ; Bennish, Michael L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-c5b7da3c25bf747090c5d175c60e6cf4e77979bb90007085938f951694e69c383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Age Factors</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diarrhea - complications</topic><topic>Diarrhea - diagnosis</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - mortality</topic><topic>Diarrhea, Infantile - complications</topic><topic>Diarrhea, Infantile - diagnosis</topic><topic>Diarrhea, Infantile - microbiology</topic><topic>Diarrhea, Infantile - mortality</topic><topic>Dysentery, Bacillary - complications</topic><topic>Dysentery, Bacillary - diagnosis</topic><topic>Dysentery, Bacillary - mortality</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Population</topic><topic>Shigella - isolation & purification</topic><topic>Tropical bacterial diseases</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huskins, W.Charles</creatorcontrib><creatorcontrib>Griffiths, Jeffrey K.</creatorcontrib><creatorcontrib>Faruque, A.S.G.</creatorcontrib><creatorcontrib>Bennish, Michael L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huskins, W.Charles</au><au>Griffiths, Jeffrey K.</au><au>Faruque, A.S.G.</au><au>Bennish, Michael L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shigellosis in neonates and young infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>125</volume><issue>1</issue><spage>14</spage><epage>22</epage><pages>14-22</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract><![CDATA[To determine the clinical features and outcome of shigellosis in young infants, we reviewed the hospital records of 159 infants ≤ 3 months of age (including 30 neonates) and 159 children 1 to 10 years of age with shigellosis who were admitted to the Diarrhoea Treatment Centre in Dacca, Bangladesh. Infants more commonly had a history of nonbloody diarrhea (82.8% vs 42.7%;
p <0.001), moderate or severe dehydration (59.9% vs 32.1%;
p <0.001), or bacteremia (12.0% vs 5.0%;
p = 0.027) and less commonly had fever (32.7% vs 58.6%;
p <0.001), abdominal tenderness (1.9% vs 12.6%;
p <0.001), or rectal prolapse (0% vs 8.3%;
p = 0.001). Infections caused by
Shigella boydii (20.8% vs 6.3%;
p <0.001) and
Shigella sonnei (7.5% vs 1.3%;
p = 0.006) were more common, and
Shigella dysenteriae type 1 (9.4% vs 31.4%;
p <0.001) infections were less common in infants than in older children; the proportion of
Shigella flexneri infections was equivalent in the two groups (59.1% vs 60.4%). Infants were twice as likely to die as older children (16.4% vs 8.2%;
p = 0.026). Only 17 infants (14.3%) were being exclusively breast fed at the onset of their illness. In a multiple logistic regression analysis, independent predictors of death in infants were gram-negative bacteremia, ileus, decreased bowel sounds, hyponatremia, hypoproteinemia, and a lower number of erythrocytes detected on microscopic examination of stool specimens. Diarrhea management algorithms that rely only on clinical findings of dysentery to diagnose and treat shigellosis are likely to be unreliable in this high-risk age group. (J P
EDIATR 1994;125:14-22)]]></abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8021764</pmid><doi>10.1016/S0022-3476(94)70115-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1994-07, Vol.125 (1), p.14-22 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Age Factors Bacterial diseases Biological and medical sciences Child Child, Preschool Diarrhea - complications Diarrhea - diagnosis Diarrhea - microbiology Diarrhea - mortality Diarrhea, Infantile - complications Diarrhea, Infantile - diagnosis Diarrhea, Infantile - microbiology Diarrhea, Infantile - mortality Dysentery, Bacillary - complications Dysentery, Bacillary - diagnosis Dysentery, Bacillary - mortality Female Human bacterial diseases Humans Infant Infant, Newborn Infectious diseases Logistic Models Male Medical sciences Miscellaneous Population Shigella - isolation & purification Tropical bacterial diseases Tropical medicine |
| title | Shigellosis in neonates and young infants |
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