Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi
OBJECTIVE: Our purpose was to describe the clinical utility of a deoxyribonucleic acid amplification method for determining fetal RhD status in alloimmunized pregnancies STUDY DESIGN: Six RhD-negative women with alloimmunized pregnancies and heterozygous partners underwent amniocentesis (n = 5) or c...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1994-07, Vol.171 (1), p.50-54 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 171 |
| creator | Fisk, Nicholas M. Bennett, Phillip Warwick, Ruth M. Letsky, Elizabeth A. Welch, Ross Vaughan, Janet I. Moore, Gudrun |
| description | OBJECTIVE: Our purpose was to describe the clinical utility of a deoxyribonucleic acid amplification method for determining fetal RhD status in alloimmunized pregnancies
STUDY DESIGN: Six RhD-negative women with alloimmunized pregnancies and heterozygous partners underwent amniocentesis (n = 5) or chorionic villus sampling (n = 1). Fetal RhD type was determined by polymerase chain reaction and results disclosed to the attending physicians.
RESULTS: Knowledge of the fetal RhD status avoided further invasive procedures in two pregnancies and facilitated the timing or performance of intrauterine transfusions in the remainder.
CONCLUSIONS: In alloimmunized pregnancies the ability to RhD-type the fetus in amniotic fluid avoids the risks of fetomaternal. hemorrhage and increased sensitization associated with fetal blood sampling or chorionic biopsy. This allows more rational pregnancy management, avoiding invasive procedures in the presence of an RhD-negative fetus, or planning therapeutic interventions or offering termination of pregnancy in the presence of an RhD-positive fetus. |
| doi_str_mv | 10.1016/S0002-9378(94)70076-1 |
| format | Article |
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STUDY DESIGN: Six RhD-negative women with alloimmunized pregnancies and heterozygous partners underwent amniocentesis (n = 5) or chorionic villus sampling (n = 1). Fetal RhD type was determined by polymerase chain reaction and results disclosed to the attending physicians.
RESULTS: Knowledge of the fetal RhD status avoided further invasive procedures in two pregnancies and facilitated the timing or performance of intrauterine transfusions in the remainder.
CONCLUSIONS: In alloimmunized pregnancies the ability to RhD-type the fetus in amniotic fluid avoids the risks of fetomaternal. hemorrhage and increased sensitization associated with fetal blood sampling or chorionic biopsy. This allows more rational pregnancy management, avoiding invasive procedures in the presence of an RhD-negative fetus, or planning therapeutic interventions or offering termination of pregnancy in the presence of an RhD-positive fetus.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(94)70076-1</identifier><identifier>PMID: 8030733</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>amniocentesis ; Amniotic Fluid - cytology ; Amniotic Fluid - immunology ; Base Sequence ; Blood Grouping and Crossmatching - methods ; Chorionic Villi - immunology ; Erythroblastosis, Fetal - diagnosis ; Female ; Fetal Blood - cytology ; Fetal Blood - immunology ; fetal blood typing ; Humans ; Infant, Newborn ; Molecular Sequence Data ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Complications - immunology ; Prenatal Diagnosis ; Rh disease ; Rh Isoimmunization ; Rh-Hr Blood-Group System - analysis</subject><ispartof>American journal of obstetrics and gynecology, 1994-07, Vol.171 (1), p.50-54</ispartof><rights>1994 Mosby-Year Book, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-865d1b7b3afe7e08e8a64d7321ab6cb7bfa9860e51753fbec9a7b1a6e741c3913</citedby><cites>FETCH-LOGICAL-c360t-865d1b7b3afe7e08e8a64d7321ab6cb7bfa9860e51753fbec9a7b1a6e741c3913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9378(94)70076-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8030733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisk, Nicholas M.</creatorcontrib><creatorcontrib>Bennett, Phillip</creatorcontrib><creatorcontrib>Warwick, Ruth M.</creatorcontrib><creatorcontrib>Letsky, Elizabeth A.</creatorcontrib><creatorcontrib>Welch, Ross</creatorcontrib><creatorcontrib>Vaughan, Janet I.</creatorcontrib><creatorcontrib>Moore, Gudrun</creatorcontrib><title>Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>OBJECTIVE: Our purpose was to describe the clinical utility of a deoxyribonucleic acid amplification method for determining fetal RhD status in alloimmunized pregnancies
STUDY DESIGN: Six RhD-negative women with alloimmunized pregnancies and heterozygous partners underwent amniocentesis (n = 5) or chorionic villus sampling (n = 1). Fetal RhD type was determined by polymerase chain reaction and results disclosed to the attending physicians.
RESULTS: Knowledge of the fetal RhD status avoided further invasive procedures in two pregnancies and facilitated the timing or performance of intrauterine transfusions in the remainder.
CONCLUSIONS: In alloimmunized pregnancies the ability to RhD-type the fetus in amniotic fluid avoids the risks of fetomaternal. hemorrhage and increased sensitization associated with fetal blood sampling or chorionic biopsy. This allows more rational pregnancy management, avoiding invasive procedures in the presence of an RhD-negative fetus, or planning therapeutic interventions or offering termination of pregnancy in the presence of an RhD-positive fetus.</description><subject>amniocentesis</subject><subject>Amniotic Fluid - cytology</subject><subject>Amniotic Fluid - immunology</subject><subject>Base Sequence</subject><subject>Blood Grouping and Crossmatching - methods</subject><subject>Chorionic Villi - immunology</subject><subject>Erythroblastosis, Fetal - diagnosis</subject><subject>Female</subject><subject>Fetal Blood - cytology</subject><subject>Fetal Blood - immunology</subject><subject>fetal blood typing</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - immunology</subject><subject>Prenatal Diagnosis</subject><subject>Rh disease</subject><subject>Rh Isoimmunization</subject><subject>Rh-Hr Blood-Group System - analysis</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rHCEUxaU0pNttP0LAp9I-TKvrjs48lbLpPwgE0vZZHOdOcoujU3UC00-Qj10nu-S1IIj-7vHgOYRccPaeMy4__GCM7apWqOZtu3-nGFOy4s_IhrNWVbKRzXOyeRp5QV6m9Hs97trdOTlvmGBKiA15ODj0aI2jc0aHeaFhoAPkcnFzd0nzMqG_peipcS7gOM4e_0JPpwi33niLkGi30BGMT6tyCm4ZIZoE1N6ZIotgbMbgaVlm9BjskosmxMJDLAAtvUfn8BU5G4xL8Pq0b8mvL59_Hr5VV9dfvx8-XVVWSJarRtY971QnzAAKWAONkfteiR03nbQFDKZtJIOaq1oMHdjWqI4bCWrPrWi52JI3x3enGP7MkLIeMVlwzngIc9JK1k3NinhL6uOgjSGlCIOeIo4mLpozvTagHxvQa7y63evHBvRqcHEymLsR-ifVKfLCPx45lF_eI0SdSozeQo8RbNZ9wP84_ANa15j7</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Fisk, Nicholas M.</creator><creator>Bennett, Phillip</creator><creator>Warwick, Ruth M.</creator><creator>Letsky, Elizabeth A.</creator><creator>Welch, Ross</creator><creator>Vaughan, Janet I.</creator><creator>Moore, Gudrun</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi</title><author>Fisk, Nicholas M. ; Bennett, Phillip ; Warwick, Ruth M. ; Letsky, Elizabeth A. ; Welch, Ross ; Vaughan, Janet I. ; Moore, Gudrun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-865d1b7b3afe7e08e8a64d7321ab6cb7bfa9860e51753fbec9a7b1a6e741c3913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>amniocentesis</topic><topic>Amniotic Fluid - cytology</topic><topic>Amniotic Fluid - immunology</topic><topic>Base Sequence</topic><topic>Blood Grouping and Crossmatching - methods</topic><topic>Chorionic Villi - immunology</topic><topic>Erythroblastosis, Fetal - diagnosis</topic><topic>Female</topic><topic>Fetal Blood - cytology</topic><topic>Fetal Blood - immunology</topic><topic>fetal blood typing</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - immunology</topic><topic>Prenatal Diagnosis</topic><topic>Rh disease</topic><topic>Rh Isoimmunization</topic><topic>Rh-Hr Blood-Group System - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisk, Nicholas M.</creatorcontrib><creatorcontrib>Bennett, Phillip</creatorcontrib><creatorcontrib>Warwick, Ruth M.</creatorcontrib><creatorcontrib>Letsky, Elizabeth A.</creatorcontrib><creatorcontrib>Welch, Ross</creatorcontrib><creatorcontrib>Vaughan, Janet I.</creatorcontrib><creatorcontrib>Moore, Gudrun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisk, Nicholas M.</au><au>Bennett, Phillip</au><au>Warwick, Ruth M.</au><au>Letsky, Elizabeth A.</au><au>Welch, Ross</au><au>Vaughan, Janet I.</au><au>Moore, Gudrun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>171</volume><issue>1</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>OBJECTIVE: Our purpose was to describe the clinical utility of a deoxyribonucleic acid amplification method for determining fetal RhD status in alloimmunized pregnancies
STUDY DESIGN: Six RhD-negative women with alloimmunized pregnancies and heterozygous partners underwent amniocentesis (n = 5) or chorionic villus sampling (n = 1). Fetal RhD type was determined by polymerase chain reaction and results disclosed to the attending physicians.
RESULTS: Knowledge of the fetal RhD status avoided further invasive procedures in two pregnancies and facilitated the timing or performance of intrauterine transfusions in the remainder.
CONCLUSIONS: In alloimmunized pregnancies the ability to RhD-type the fetus in amniotic fluid avoids the risks of fetomaternal. hemorrhage and increased sensitization associated with fetal blood sampling or chorionic biopsy. This allows more rational pregnancy management, avoiding invasive procedures in the presence of an RhD-negative fetus, or planning therapeutic interventions or offering termination of pregnancy in the presence of an RhD-positive fetus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8030733</pmid><doi>10.1016/S0002-9378(94)70076-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1994-07, Vol.171 (1), p.50-54 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | amniocentesis Amniotic Fluid - cytology Amniotic Fluid - immunology Base Sequence Blood Grouping and Crossmatching - methods Chorionic Villi - immunology Erythroblastosis, Fetal - diagnosis Female Fetal Blood - cytology Fetal Blood - immunology fetal blood typing Humans Infant, Newborn Molecular Sequence Data Polymerase Chain Reaction Pregnancy Pregnancy Complications - immunology Prenatal Diagnosis Rh disease Rh Isoimmunization Rh-Hr Blood-Group System - analysis |
| title | Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction on amniocytes or chorionic villi |
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