Age-dependent regulation of the tumorigenic potential of neoplastically transformed rat liver epithelial cells by the liver microenvironment
Neoplastically transformed rat liver epithelial cell lines (GN6TF and GP7TB), which form tumors with short latency at s.c. or i.p. transplantation sites of syngeneic rats, did not form tumors or were weakly tumorigenic following transplantation into the livers of young adult rats and expressed incre...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1994-07, Vol.54 (14), p.3668-3671 |
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| creator | MCCULLOUGH, K. D COLEMAN, W. B SMITH, G. J GRISHAM, J. W |
| description | Neoplastically transformed rat liver epithelial cell lines (GN6TF and GP7TB), which form tumors with short latency at s.c. or i.p. transplantation sites of syngeneic rats, did not form tumors or were weakly tumorigenic following transplantation into the livers of young adult rats and expressed increasing tumorigenicity in livers of increasingly aged rats. These results suggest that progressive alterations in the hepatic parenchyma with increasing age enabled tumor formation by providing a less suppressive microenvironment for expression of the tumorigenic phenotype. Age is widely recognized as a significant risk factor in the development of neoplasia; this study describes a model for investigation of the influence of age-dependent changes in the hepatic microenvironment on the development of hepatic cancer. |
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Age is widely recognized as a significant risk factor in the development of neoplasia; this study describes a model for investigation of the influence of age-dependent changes in the hepatic microenvironment on the development of hepatic cancer.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 8033081</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Age Factors ; Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Cell Line ; Cell Transformation, Neoplastic ; Epithelium - pathology ; Experimental digestive system and abdominal tumors ; Liver - pathology ; Liver Neoplasms, Experimental - etiology ; Male ; Medical sciences ; Neoplasm Transplantation ; Rats ; Rats, Inbred F344 ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 1994-07, Vol.54 (14), p.3668-3671</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4164772$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8033081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCCULLOUGH, K. D</creatorcontrib><creatorcontrib>COLEMAN, W. B</creatorcontrib><creatorcontrib>SMITH, G. J</creatorcontrib><creatorcontrib>GRISHAM, J. W</creatorcontrib><title>Age-dependent regulation of the tumorigenic potential of neoplastically transformed rat liver epithelial cells by the liver microenvironment</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Neoplastically transformed rat liver epithelial cell lines (GN6TF and GP7TB), which form tumors with short latency at s.c. or i.p. transplantation sites of syngeneic rats, did not form tumors or were weakly tumorigenic following transplantation into the livers of young adult rats and expressed increasing tumorigenicity in livers of increasingly aged rats. These results suggest that progressive alterations in the hepatic parenchyma with increasing age enabled tumor formation by providing a less suppressive microenvironment for expression of the tumorigenic phenotype. Age is widely recognized as a significant risk factor in the development of neoplasia; this study describes a model for investigation of the influence of age-dependent changes in the hepatic microenvironment on the development of hepatic cancer.</description><subject>Age Factors</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic</subject><subject>Epithelium - pathology</subject><subject>Experimental digestive system and abdominal tumors</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms, Experimental - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Transplantation</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1qwzAQhEVpSdO0j1DQofRmkC1Lso8h9A8CvbRnI9nrREWWXEkO5B360FUa09OyfLPDzlygZc5olYmyZJdoSQipMlaK4hrdhPCVVpYTtkCLilBKqnyJftY7yDoYwXZgI_awm4yM2lnsehz3gOM0OK93YHWLRxeTSEtzghbcaGSIupXGHHH00obe-QE67GXERh_AYxh1MjGnkxaMCVgd_1zPdNCtd2AP2js7JOdbdNVLE-Buniv0-fz0sXnNtu8vb5v1NtsXvI5ZKUUBTDFZCFryruKtJLkqWdupFKoGEJxCnTPVQ90rThUVqpaKtOm6zzmhK_R49h29-54gxGbQ4fSfTKGm0AjOKko5T8L7WTipFKwZvR6kPzZzfYk_zFyGVEOfOmh1-JeVOS-FKOgvRE99mg</recordid><startdate>19940715</startdate><enddate>19940715</enddate><creator>MCCULLOUGH, K. 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These results suggest that progressive alterations in the hepatic parenchyma with increasing age enabled tumor formation by providing a less suppressive microenvironment for expression of the tumorigenic phenotype. Age is widely recognized as a significant risk factor in the development of neoplasia; this study describes a model for investigation of the influence of age-dependent changes in the hepatic microenvironment on the development of hepatic cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8033081</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1994-07, Vol.54 (14), p.3668-3671 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Animal tumors. Experimental tumors Animals Biological and medical sciences Cell Line Cell Transformation, Neoplastic Epithelium - pathology Experimental digestive system and abdominal tumors Liver - pathology Liver Neoplasms, Experimental - etiology Male Medical sciences Neoplasm Transplantation Rats Rats, Inbred F344 Tumors |
| title | Age-dependent regulation of the tumorigenic potential of neoplastically transformed rat liver epithelial cells by the liver microenvironment |
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