Impact of lipofuscin on the retinal pigment epithelium: electroretinographic evaluation of a protease inhibition model

With aging, the retinal pigment epithelium (RPE) becomes increasingly congested with residual debris called lipofuscin. Little is known about the impact of lipofuscin on retinal function, and this was addressed in the present study by examining the influence of RPE debris on electroretinographic (ER...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 1994-04, Vol.232 (4), p.232-237
Hauptverfasser:	RAPP, L. M, FISHER, P. L, SHEINBERG, C. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dark Adaptation Disease Models, Animal Electroretinography Female Injections Investigative techniques of ocular function and vision Investigative techniques, diagnostic techniques (general aspects) Leupeptins - pharmacology Lipofuscin - metabolism Medical sciences Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Rats Retina - metabolism Retina - physiology Retina - ultrastructure Vitreous Body
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