Zinc and copper levels in premenstrual syndrome
To determine whether changes in peripheral zinc and copper levels are associated with symptoms of premenstrual syndrome (PMS). Ten PMS patients and 10 controls gave blood at 2- or 3-day intervals through three menstrual cycles. Serum zinc and copper were measured by flameless atomic absorption spect...
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| Veröffentlicht in: | Fertility and sterility 1994-08, Vol.62 (2), p.313-320 |
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| container_title | Fertility and sterility |
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| creator | Chuong, C. James Dawson, Earl B. |
| description | To determine whether changes in peripheral zinc and copper levels are associated with symptoms of premenstrual syndrome (PMS).
Ten PMS patients and 10 controls gave blood at 2- or 3-day intervals through three menstrual cycles. Serum zinc and copper were measured by flameless atomic absorption spectrophotometry.
In the controls, zinc values were not significantly different between the follicular and the luteal phases. In the patients, the values were significantly lower during the luteal phase than during the follicular phase. Lower levels of zinc during the luteal phase in PMS patients, compared with the controls, were noted. Copper levels were noted to be higher during the luteal phase in PMS patients compared with the controls. Because copper competes with zinc for intestinal absorption and serum protein binding sites, zinc:copper ratio can reflect the availability of zinc in the body. The computation of this ratio revealed that the ratio was significantly lower in the patients than those in the controls during the luteal phase.
Our data suggest that zinc deficiency occurs in PMS patients during the luteal phase, and the availability of zinc in PMS patients during the luteal phase is further reduced by the elevated copper. |
| doi_str_mv | 10.1016/S0015-0282(16)56884-8 |
| format | Article |
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Ten PMS patients and 10 controls gave blood at 2- or 3-day intervals through three menstrual cycles. Serum zinc and copper were measured by flameless atomic absorption spectrophotometry.
In the controls, zinc values were not significantly different between the follicular and the luteal phases. In the patients, the values were significantly lower during the luteal phase than during the follicular phase. Lower levels of zinc during the luteal phase in PMS patients, compared with the controls, were noted. Copper levels were noted to be higher during the luteal phase in PMS patients compared with the controls. Because copper competes with zinc for intestinal absorption and serum protein binding sites, zinc:copper ratio can reflect the availability of zinc in the body. The computation of this ratio revealed that the ratio was significantly lower in the patients than those in the controls during the luteal phase.
Our data suggest that zinc deficiency occurs in PMS patients during the luteal phase, and the availability of zinc in PMS patients during the luteal phase is further reduced by the elevated copper.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)56884-8</identifier><identifier>PMID: 8034078</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; copper ; Copper - blood ; Female ; Female genital diseases ; Follicular Phase ; Gynecology. Andrology. Obstetrics ; Humans ; Luteal Phase ; Medical sciences ; Non tumoral diseases ; Premenstrual syndrome ; Premenstrual Syndrome - blood ; Premenstrual Syndrome - physiopathology ; Reference Values ; Severity of Illness Index ; Spectrophotometry, Atomic ; Surveys and Questionnaires ; zinc ; Zinc - blood</subject><ispartof>Fertility and sterility, 1994-08, Vol.62 (2), p.313-320</ispartof><rights>1994 American Society for Reproductive Medicine</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-73d709c9c189d9a52d4725edb1a4f3f43dee45ec866fd218f72117ee31b04b8d3</citedby><cites>FETCH-LOGICAL-c389t-73d709c9c189d9a52d4725edb1a4f3f43dee45ec866fd218f72117ee31b04b8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)56884-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4242039$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8034078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chuong, C. James</creatorcontrib><creatorcontrib>Dawson, Earl B.</creatorcontrib><title>Zinc and copper levels in premenstrual syndrome</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To determine whether changes in peripheral zinc and copper levels are associated with symptoms of premenstrual syndrome (PMS).
Ten PMS patients and 10 controls gave blood at 2- or 3-day intervals through three menstrual cycles. Serum zinc and copper were measured by flameless atomic absorption spectrophotometry.
In the controls, zinc values were not significantly different between the follicular and the luteal phases. In the patients, the values were significantly lower during the luteal phase than during the follicular phase. Lower levels of zinc during the luteal phase in PMS patients, compared with the controls, were noted. Copper levels were noted to be higher during the luteal phase in PMS patients compared with the controls. Because copper competes with zinc for intestinal absorption and serum protein binding sites, zinc:copper ratio can reflect the availability of zinc in the body. The computation of this ratio revealed that the ratio was significantly lower in the patients than those in the controls during the luteal phase.
Our data suggest that zinc deficiency occurs in PMS patients during the luteal phase, and the availability of zinc in PMS patients during the luteal phase is further reduced by the elevated copper.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>copper</subject><subject>Copper - blood</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follicular Phase</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Luteal Phase</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Premenstrual syndrome</subject><subject>Premenstrual Syndrome - blood</subject><subject>Premenstrual Syndrome - physiopathology</subject><subject>Reference Values</subject><subject>Severity of Illness Index</subject><subject>Spectrophotometry, Atomic</subject><subject>Surveys and Questionnaires</subject><subject>zinc</subject><subject>Zinc - blood</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMoOi6PIPRBRA_tZF9OIoMbCB7Ui5eQTqoh0pvJjODb2zPTzNVTUdT3VxUfQucE3xBM5PwNYyJKTDW9IvJaSK15qffQjAghSyEF20ezHXKEjnP-whhLoughOtSYcaz0DM0_Y-cL14XC98MAqWjgB5pcxK4YErTQ5WVauabIv11IfQun6KB2TYazqZ6gj4f798VT-fL6-Ly4eyk902ZZKhYUNt54ok0wTtDAFRUQKuJ4zWrOAgAX4LWUdaBE14oSogAYqTCvdGAn6HK7d0j99wry0rYxe2ga10G_ylZJoYwxagTFFvSpzzlBbYcUW5d-LcF2LcpuRNm1BTt2G1FWj7nz6cCqaiHsUpOZcX4xzV32rqmT63zMO4xTTjEzI3a7xUZp8BMh2ewjdB5CTOCXNvTxn0f-ADSIg8I</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>Chuong, C. James</creator><creator>Dawson, Earl B.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940801</creationdate><title>Zinc and copper levels in premenstrual syndrome</title><author>Chuong, C. James ; Dawson, Earl B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-73d709c9c189d9a52d4725edb1a4f3f43dee45ec866fd218f72117ee31b04b8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>copper</topic><topic>Copper - blood</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follicular Phase</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Luteal Phase</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Premenstrual syndrome</topic><topic>Premenstrual Syndrome - blood</topic><topic>Premenstrual Syndrome - physiopathology</topic><topic>Reference Values</topic><topic>Severity of Illness Index</topic><topic>Spectrophotometry, Atomic</topic><topic>Surveys and Questionnaires</topic><topic>zinc</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chuong, C. James</creatorcontrib><creatorcontrib>Dawson, Earl B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chuong, C. James</au><au>Dawson, Earl B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc and copper levels in premenstrual syndrome</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>62</volume><issue>2</issue><spage>313</spage><epage>320</epage><pages>313-320</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To determine whether changes in peripheral zinc and copper levels are associated with symptoms of premenstrual syndrome (PMS).
Ten PMS patients and 10 controls gave blood at 2- or 3-day intervals through three menstrual cycles. Serum zinc and copper were measured by flameless atomic absorption spectrophotometry.
In the controls, zinc values were not significantly different between the follicular and the luteal phases. In the patients, the values were significantly lower during the luteal phase than during the follicular phase. Lower levels of zinc during the luteal phase in PMS patients, compared with the controls, were noted. Copper levels were noted to be higher during the luteal phase in PMS patients compared with the controls. Because copper competes with zinc for intestinal absorption and serum protein binding sites, zinc:copper ratio can reflect the availability of zinc in the body. The computation of this ratio revealed that the ratio was significantly lower in the patients than those in the controls during the luteal phase.
Our data suggest that zinc deficiency occurs in PMS patients during the luteal phase, and the availability of zinc in PMS patients during the luteal phase is further reduced by the elevated copper.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8034078</pmid><doi>10.1016/S0015-0282(16)56884-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1994-08, Vol.62 (2), p.313-320 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences copper Copper - blood Female Female genital diseases Follicular Phase Gynecology. Andrology. Obstetrics Humans Luteal Phase Medical sciences Non tumoral diseases Premenstrual syndrome Premenstrual Syndrome - blood Premenstrual Syndrome - physiopathology Reference Values Severity of Illness Index Spectrophotometry, Atomic Surveys and Questionnaires zinc Zinc - blood |
| title | Zinc and copper levels in premenstrual syndrome |
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