Novel gene HCS1 is specifically expressed in the giant interneurones of the terrestrial snail
THE terrestrial snail Helix lucorum is a promising model for molecular neurobiology since its central nervous system (CNS) is simple and contains many morphologically and functionally identified large neurones. Among these, the giant interneurones located in pleural and parietal ganglia are especial...
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| Veröffentlicht in: | Neuroreport 1994-01, Vol.5 (5), p.589-592 |
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| creator | Bogdanov, Yuri D Ovchinnikov, Dmitri A Balaban, Pavel M Belyavsky, Alexander V |
| description | THE terrestrial snail Helix lucorum is a promising model for molecular neurobiology since its central nervous system (CNS) is simple and contains many morphologically and functionally identified large neurones. Among these, the giant interneurones located in pleural and parietal ganglia are especially interesting because they trigger the withdrawal behaviour of the snail and participate in aversive conditioning. Here we describe the identification and characterization of a gene named HCS1 which is preferentially expressed in these interneurones. It encodes a putative protein 100 amino acids long containing an N-terminal hydrophobic leader peptide. No sequences with significant homology to HCS1 were found in the protein (Swiss-Prot) and nucleotide (EMBLbank) data libraries. We suppose that the product of this gene is a secreted protein, presumably a neuropeptide or a growth factor. |
| doi_str_mv | 10.1097/00001756-199401000-00014 |
| format | Article |
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Among these, the giant interneurones located in pleural and parietal ganglia are especially interesting because they trigger the withdrawal behaviour of the snail and participate in aversive conditioning. Here we describe the identification and characterization of a gene named HCS1 which is preferentially expressed in these interneurones. It encodes a putative protein 100 amino acids long containing an N-terminal hydrophobic leader peptide. No sequences with significant homology to HCS1 were found in the protein (Swiss-Prot) and nucleotide (EMBLbank) data libraries. 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| ispartof | Neuroreport, 1994-01, Vol.5 (5), p.589-592 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76578916 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Amino Acid Sequence Animals Base Sequence DNA, Complementary - genetics Gene Expression Genes Helix (Snails) - genetics Helix (Snails) - metabolism Helix lucorum Interneurons - metabolism Molecular Sequence Data Neuropeptides - biosynthesis Neuropeptides - genetics Polymerase Chain Reaction |
| title | Novel gene HCS1 is specifically expressed in the giant interneurones of the terrestrial snail |
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