Effects of Ischaemic Conditions on Uptake of Glutamate, Aspartate, and Noradrenaline by Cell Lines Derived from the Human Nervous System

: The effect of hypoglycaemic, hypoxic, and ischaemic conditions on high‐affinity neurotransmitter transport was studied in the human astrocytoma clone D384 and the human neuroblastoma clone SH‐SY5Y. Both cell lines expressed a sodium‐dependent glutamate/aspartate transporter. Km values for d‐[3H]as...

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Veröffentlicht in:	Journal of neurochemistry 1994-08, Vol.63 (2), p.603-611
Hauptverfasser:	O'Neill, Clare M., Ball, Stephen G., Vaughan, Peter F. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid - metabolism Astrocytoma Biological and medical sciences Biological Transport Cell Hypoxia Cell Line Fundamental and applied biological sciences. Psychology Glioma Glutamates - metabolism Glutamic Acid Humans Hypoglycemia Ischaemic Ischemia Isolated neuron and nerve. Neuroglia Kinetics Models, Neurological Neuroblastoma Neurotransmitter transport Norepinephrine - metabolism Tritium Tumor Cells, Cultured Vertebrates: nervous system and sense organs
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