Recent applications of enzymatic peptide synthesis
Recent applications of enzyme catalysis in peptide synthesis are reviewed. A brief history of the development of these techniques is presented, and existing strategies and tactics of regio- and stereospecific peptide bond syntheses catalyzed by proteolytic enzymes are summarized. The recent literatu...
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| Veröffentlicht in: | Peptides 1994, Vol.15 (1), p.183-193 |
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| container_end_page | 193 |
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| container_title | Peptides |
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| creator | Bongers, Jacob Heimer, Edgar P. |
| description | Recent applications of enzyme catalysis in peptide synthesis are reviewed. A brief history of the development of these techniques is presented, and existing strategies and tactics of regio- and stereospecific peptide bond syntheses catalyzed by proteolytic enzymes are summarized. The recent literature (ca. 1987–1992) is surveyed for selected applications of enzyme catalysis to the synthesis of bioactive peptides and analogues, semisynthetic proteins and protein conjugates, and bioactive peptides from recombinant precursors. Newly isolated natural enzymes as well as chemically modified forms and recombinant mutants of the natural enzymes of potential utility in peptide synthesis are also reviewed. |
| doi_str_mv | 10.1016/0196-9781(94)90189-9 |
| format | Article |
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A brief history of the development of these techniques is presented, and existing strategies and tactics of regio- and stereospecific peptide bond syntheses catalyzed by proteolytic enzymes are summarized. The recent literature (ca. 1987–1992) is surveyed for selected applications of enzyme catalysis to the synthesis of bioactive peptides and analogues, semisynthetic proteins and protein conjugates, and bioactive peptides from recombinant precursors. 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Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Catalysis</subject><subject>Endopeptidases - chemistry</subject><subject>Endopeptidases - classification</subject><subject>Enzymatic</subject><subject>Enzyme catalyzed</subject><subject>Enzymes - metabolism</subject><subject>Enzymic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Molecular Sequence Data</subject><subject>Peptide amidation</subject><subject>Peptide Biosynthesis</subject><subject>Peptide semisynthesis</subject><subject>Peptide synthesis</subject><subject>Protease</subject><subject>Proteinase</subject><subject>Proteins</subject><subject>Thermodynamics</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDNWnSfFwEWfyCBUH0HNJ0gpF-mXSF9dfbumWPnoZhnndmeBA6JfiaYMJvMFE8VUKSS8WuFCZSpWoPzYkUNM0JV_tovkMO0VGMnxhjxpScoZnEJFdCzFH2ChaaPjFdV3lret82MWldAs3Pph5am3TQ9b6EJG6a_gOij8fowJkqwslUF-j94f5t-ZSuXh6fl3er1LI861OWO5CZkmVRYAJOcccNYSaXHGfUMW4JwdYZKbLCGUY5KFtyDNYISTkpc7pAF9u9XWi_1hB7XftooapMA-06asFzIaggA8i2oA1tjAGc7oKvTdhogvWoSo8e9OhBK6b_VGk1xM6m_euihnIXmtwM8_NpbqI1lQumsT7uMKoYxnS8frvFYHDx7SHoaD00FkofwPa6bP3_f_wCZkuEow</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Bongers, Jacob</creator><creator>Heimer, Edgar P.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Recent applications of enzymatic peptide synthesis</title><author>Bongers, Jacob ; Heimer, Edgar P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-45fe8298dbb01ef96f6a14a586023f46c110cfa872bfa436e9cd60eca78361d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acyl transfer</topic><topic>Acylation</topic><topic>Amino Acid Sequence</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Catalysis</topic><topic>Endopeptidases - chemistry</topic><topic>Endopeptidases - classification</topic><topic>Enzymatic</topic><topic>Enzyme catalyzed</topic><topic>Enzymes - metabolism</topic><topic>Enzymic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Molecular Sequence Data</topic><topic>Peptide amidation</topic><topic>Peptide Biosynthesis</topic><topic>Peptide semisynthesis</topic><topic>Peptide synthesis</topic><topic>Protease</topic><topic>Proteinase</topic><topic>Proteins</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bongers, Jacob</creatorcontrib><creatorcontrib>Heimer, Edgar P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bongers, Jacob</au><au>Heimer, Edgar P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent applications of enzymatic peptide synthesis</atitle><jtitle>Peptides</jtitle><addtitle>Peptides</addtitle><date>1994</date><risdate>1994</risdate><volume>15</volume><issue>1</issue><spage>183</spage><epage>193</epage><pages>183-193</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Recent applications of enzyme catalysis in peptide synthesis are reviewed. A brief history of the development of these techniques is presented, and existing strategies and tactics of regio- and stereospecific peptide bond syntheses catalyzed by proteolytic enzymes are summarized. The recent literature (ca. 1987–1992) is surveyed for selected applications of enzyme catalysis to the synthesis of bioactive peptides and analogues, semisynthetic proteins and protein conjugates, and bioactive peptides from recombinant precursors. Newly isolated natural enzymes as well as chemically modified forms and recombinant mutants of the natural enzymes of potential utility in peptide synthesis are also reviewed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8015977</pmid><doi>10.1016/0196-9781(94)90189-9</doi><tpages>11</tpages></addata></record> |
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| ispartof | Peptides, 1994, Vol.15 (1), p.183-193 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acyl transfer Acylation Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biological and medical sciences Catalysis Endopeptidases - chemistry Endopeptidases - classification Enzymatic Enzyme catalyzed Enzymes - metabolism Enzymic Fundamental and applied biological sciences. Psychology Kinetics Molecular Sequence Data Peptide amidation Peptide Biosynthesis Peptide semisynthesis Peptide synthesis Protease Proteinase Proteins Thermodynamics |
| title | Recent applications of enzymatic peptide synthesis |
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