ANTITUMOR EFFECT OF TUMOR NECROSIS FACTOR AGAINST VARIOUS PRIMARILY CULTURED HUMAN CANCER CELLS
The antitumor activity of tumor necrosis factor (TNF) against various primarily cultured human cancer cells (32 cases) was investigated by the 51Cr cytotoxic release assay and the tumor stem cell assay. Over 50% sensitivity (the ratio to the cytotoxicity in L929 cells) was noted in 4 of 14 cases of...
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| Veröffentlicht in: | Japanese Journal of Cancer Research GANN 1985, Vol.76(11), pp.1115-1119 |
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| container_issue | 11 |
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| container_title | Japanese Journal of Cancer Research GANN |
| container_volume | 76 |
| creator | WATANABE, Naoki NIITSU, Yoshiro NEDA, Hiroshi SONE, Hisao YAMAUCHI, Naofumi UMETSU, Tomofumi URUSHIZAKI, Ichiro |
| description | The antitumor activity of tumor necrosis factor (TNF) against various primarily cultured human cancer cells (32 cases) was investigated by the 51Cr cytotoxic release assay and the tumor stem cell assay. Over 50% sensitivity (the ratio to the cytotoxicity in L929 cells) was noted in 4 of 14 cases of gastric cancer (28.6%), 7 of 9 cases of leukemic cells (77.8%), and 1 case each of pancreatic carcinoma and ovarian cancer. Scarcely any sensitivity, however, was observed in 1 case of acute promyelocytic leukemia or in some of the gastric cancer cases. No correlation was observed between the histological type of the cancer and TNF sensitivity. The above results seem to confirm that TNF has significant antitumor activity against human cancer cells. |
| doi_str_mv | 10.20772/cancersci1985.76.11_1115 |
| format | Article |
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Over 50% sensitivity (the ratio to the cytotoxicity in L929 cells) was noted in 4 of 14 cases of gastric cancer (28.6%), 7 of 9 cases of leukemic cells (77.8%), and 1 case each of pancreatic carcinoma and ovarian cancer. Scarcely any sensitivity, however, was observed in 1 case of acute promyelocytic leukemia or in some of the gastric cancer cases. No correlation was observed between the histological type of the cancer and TNF sensitivity. The above results seem to confirm that TNF has significant antitumor activity against human cancer cells.</description><subject>51Cr cytotoxic release assay</subject><subject>Adult</subject><subject>Aged</subject><subject>Antitumor effect</subject><subject>Ascites</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Female</subject><subject>Glycoproteins - pharmacology</subject><subject>Glycoproteins - therapeutic use</subject><subject>Human cancer cell</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - therapy</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Tumor cell</subject><subject>Tumor necrosis factor (TNF)</subject><subject>Tumor Necrosis Factor-alpha</subject><subject>Tumor stem cell assay</subject><subject>Tumors</subject><issn>0910-5050</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1LwzAUhoMoc05_ghBBvOvMR5O0lyW2s9C10g_Bq5LVVDu6qc124b83sjIRDjl58z6cwHkBuMFoTpAQ5L5R20YPpumw77G54HOMa4wxOwFT7AnuuFzQUzBFPkYOQwydgwtj1ghhgTiZgAn1KfcomoI6SMu4rJZZDsMoCmUJswgedBrKPCviAkaBLK0OFkGcFiV8DvI4qwr4lMdLe01eoKySssrDB_hYLYMUyiCVYQ5lmCTFJThrVW_01dhnoIrCUj46SbaIZZA4a1fwnSNUi1yCfK7oShCtscuVUK7HPMqU5sIlCnH7wOhKtR4VLWlaTEm74ohjF3E6A3eHuZ_Dx9dem1296Uyj-15t9cfe1IIzW1RY8HoE96uNfq0_h26jhu963Ij1b0dfmUb17WA33Zkj5jFBMPItlhywtdmpN3301bDrml7X_wKyv9t0xvM3pj_sXQ213tIft3uEgg</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>WATANABE, Naoki</creator><creator>NIITSU, Yoshiro</creator><creator>NEDA, Hiroshi</creator><creator>SONE, Hisao</creator><creator>YAMAUCHI, Naofumi</creator><creator>UMETSU, Tomofumi</creator><creator>URUSHIZAKI, Ichiro</creator><general>The Japanese Cancer Association</general><general>Japanese Cancer Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>ANTITUMOR EFFECT OF TUMOR NECROSIS FACTOR AGAINST VARIOUS PRIMARILY CULTURED HUMAN CANCER CELLS</title><author>WATANABE, Naoki ; 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Over 50% sensitivity (the ratio to the cytotoxicity in L929 cells) was noted in 4 of 14 cases of gastric cancer (28.6%), 7 of 9 cases of leukemic cells (77.8%), and 1 case each of pancreatic carcinoma and ovarian cancer. Scarcely any sensitivity, however, was observed in 1 case of acute promyelocytic leukemia or in some of the gastric cancer cases. No correlation was observed between the histological type of the cancer and TNF sensitivity. The above results seem to confirm that TNF has significant antitumor activity against human cancer cells.</abstract><cop>Tokyo</cop><pub>The Japanese Cancer Association</pub><pmid>3936830</pmid><doi>10.20772/cancersci1985.76.11_1115</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Cancer Research GANN, 1985, Vol.76(11), pp.1115-1119 |
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| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 51Cr cytotoxic release assay Adult Aged Antitumor effect Ascites Biological and medical sciences Cell Survival Cells, Cultured Female Glycoproteins - pharmacology Glycoproteins - therapeutic use Human cancer cell Humans Male Medical sciences Middle Aged Neoplasms - therapy Neoplastic Stem Cells - drug effects Tumor cell Tumor necrosis factor (TNF) Tumor Necrosis Factor-alpha Tumor stem cell assay Tumors |
| title | ANTITUMOR EFFECT OF TUMOR NECROSIS FACTOR AGAINST VARIOUS PRIMARILY CULTURED HUMAN CANCER CELLS |
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