PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species

In rat, calf, pig and rabbit retinas the two forms of pituitary adenylate cyclase activating polypeptide with 38- and 27-amino acids (PACAP-38 and PACAP-27) produce a robust stimulation of adenylyl cyclase activity. PACAP-38 acts at picomolar concentrations and is generally more potent than PACAP-27...

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Veröffentlicht in:	Brain research 1994-03, Vol.641 (1), p.132-134
Hauptverfasser:	Onali, Pierluigi, Olianas, Maria C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl cyclase Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Animals Biological and medical sciences Cattle Enzyme Activation - drug effects Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Male Mammalia Mammalian retina Neuropeptides - analysis Neuropeptides - pharmacology Pituitary adenylate cyclase activating polypeptide (PACAP) Pituitary Adenylate Cyclase-Activating Polypeptide Rabbits Radioimmunoassay Rats Rats, Sprague-Dawley Retina - enzymology Species Specificity Swine Tissue Extracts - chemistry Vasoactive Intestinal Peptide - pharmacology Vertebrates: nervous system and sense organs
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