PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species
In rat, calf, pig and rabbit retinas the two forms of pituitary adenylate cyclase activating polypeptide with 38- and 27-amino acids (PACAP-38 and PACAP-27) produce a robust stimulation of adenylyl cyclase activity. PACAP-38 acts at picomolar concentrations and is generally more potent than PACAP-27...
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| Veröffentlicht in: | Brain research 1994-03, Vol.641 (1), p.132-134 |
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| creator | Onali, Pierluigi Olianas, Maria C. |
| description | In rat, calf, pig and rabbit retinas the two forms of pituitary adenylate cyclase activating polypeptide with 38- and 27-amino acids (PACAP-38 and PACAP-27) produce a robust stimulation of adenylyl cyclase activity. PACAP-38 acts at picomolar concentrations and is generally more potent than PACAP-27. Both PACAPs are systematically more effective than the structurally homologous vasoactive intestinal peptide. Moreover, rat, calf and pig retinas contain significant amounts of PACAP-38 immunoreactivity. This study provides the first evidence for the action and occurence of PACAP in mammalian retinas. |
| doi_str_mv | 10.1016/0006-8993(94)91825-2 |
| format | Article |
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PACAP-38 acts at picomolar concentrations and is generally more potent than PACAP-27. Both PACAPs are systematically more effective than the structurally homologous vasoactive intestinal peptide. Moreover, rat, calf and pig retinas contain significant amounts of PACAP-38 immunoreactivity. This study provides the first evidence for the action and occurence of PACAP in mammalian retinas.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)91825-2</identifier><identifier>PMID: 8019839</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adenylyl cyclase ; Adenylyl Cyclases - drug effects ; Adenylyl Cyclases - metabolism ; Animals ; Biological and medical sciences ; Cattle ; Enzyme Activation - drug effects ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Male ; Mammalia ; Mammalian retina ; Neuropeptides - analysis ; Neuropeptides - pharmacology ; Pituitary adenylate cyclase activating polypeptide (PACAP) ; Pituitary Adenylate Cyclase-Activating Polypeptide ; Rabbits ; Radioimmunoassay ; Rats ; Rats, Sprague-Dawley ; Retina - enzymology ; Species Specificity ; Swine ; Tissue Extracts - chemistry ; Vasoactive Intestinal Peptide - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1994-03, Vol.641 (1), p.132-134</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-ae38aefcc2ad581c106bbb2e5ba6b73ead5888eddf0f052b92c3194aca8fad743</citedby><cites>FETCH-LOGICAL-c483t-ae38aefcc2ad581c106bbb2e5ba6b73ead5888eddf0f052b92c3194aca8fad743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)91825-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3954750$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8019839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Onali, Pierluigi</creatorcontrib><creatorcontrib>Olianas, Maria C.</creatorcontrib><title>PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>In rat, calf, pig and rabbit retinas the two forms of pituitary adenylate cyclase activating polypeptide with 38- and 27-amino acids (PACAP-38 and PACAP-27) produce a robust stimulation of adenylyl cyclase activity. PACAP-38 acts at picomolar concentrations and is generally more potent than PACAP-27. Both PACAPs are systematically more effective than the structurally homologous vasoactive intestinal peptide. Moreover, rat, calf and pig retinas contain significant amounts of PACAP-38 immunoreactivity. This study provides the first evidence for the action and occurence of PACAP in mammalian retinas.</description><subject>Adenylyl cyclase</subject><subject>Adenylyl Cyclases - drug effects</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Enzyme Activation - drug effects</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mammalia</subject><subject>Mammalian retina</subject><subject>Neuropeptides - analysis</subject><subject>Neuropeptides - pharmacology</subject><subject>Pituitary adenylate cyclase activating polypeptide (PACAP)</subject><subject>Pituitary Adenylate Cyclase-Activating Polypeptide</subject><subject>Rabbits</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Retina - enzymology</subject><subject>Species Specificity</subject><subject>Swine</subject><subject>Tissue Extracts - chemistry</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo6-zqP1DIQWQ9tOajP5KLMAx-wYJ70HOoTipOJN09JpmFBn-83c4wRz0VVfXUS_G-hLzg7C1nvH3HGGsrpbW81fUbzZVoKvGIbLjqRNWKmj0mmwvylFzn_HNppdTsilwpxrWSekN-329323saMgV6mAqOhcLo6D782MeZovdoS3hAmksYjhHKlOjkKTgc5zhHamcbISOFlQplpmGkZY80YQkj5JV1YRFJq_AAwwAxwEjzAW3A_Iw88RAzPj_XG_L944dvu8_V3ddPX3bbu8rWSpYKUCpAb60A1yhuOWv7vhfY9ND2ncR1qhQ655lnjei1sJLrGiwoD66r5Q15fdI9pOnXEXMxQ8gWY4QRp2M2Xdt0LavZf0Heat6Kji9gfQJtmnJO6M0hhQHSbDgzazpmtd6s1htdm7_pGLGcvTzrH_sB3eXoHMeyf3XeQ7YQfYLRhnzBpG7qrlnffH_CcDHtIWAyebFztOhCWvIybgr__uMPXtGt2w</recordid><startdate>19940328</startdate><enddate>19940328</enddate><creator>Onali, Pierluigi</creator><creator>Olianas, Maria C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940328</creationdate><title>PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species</title><author>Onali, Pierluigi ; Olianas, Maria C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ae38aefcc2ad581c106bbb2e5ba6b73ead5888eddf0f052b92c3194aca8fad743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenylyl cyclase</topic><topic>Adenylyl Cyclases - drug effects</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Enzyme Activation - drug effects</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mammalia</topic><topic>Mammalian retina</topic><topic>Neuropeptides - analysis</topic><topic>Neuropeptides - pharmacology</topic><topic>Pituitary adenylate cyclase activating polypeptide (PACAP)</topic><topic>Pituitary Adenylate Cyclase-Activating Polypeptide</topic><topic>Rabbits</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Retina - enzymology</topic><topic>Species Specificity</topic><topic>Swine</topic><topic>Tissue Extracts - chemistry</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onali, Pierluigi</creatorcontrib><creatorcontrib>Olianas, Maria C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onali, Pierluigi</au><au>Olianas, Maria C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-03-28</date><risdate>1994</risdate><volume>641</volume><issue>1</issue><spage>132</spage><epage>134</epage><pages>132-134</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>In rat, calf, pig and rabbit retinas the two forms of pituitary adenylate cyclase activating polypeptide with 38- and 27-amino acids (PACAP-38 and PACAP-27) produce a robust stimulation of adenylyl cyclase activity. PACAP-38 acts at picomolar concentrations and is generally more potent than PACAP-27. Both PACAPs are systematically more effective than the structurally homologous vasoactive intestinal peptide. Moreover, rat, calf and pig retinas contain significant amounts of PACAP-38 immunoreactivity. This study provides the first evidence for the action and occurence of PACAP in mammalian retinas.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8019839</pmid><doi>10.1016/0006-8993(94)91825-2</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research, 1994-03, Vol.641 (1), p.132-134 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adenylyl cyclase Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Animals Biological and medical sciences Cattle Enzyme Activation - drug effects Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Male Mammalia Mammalian retina Neuropeptides - analysis Neuropeptides - pharmacology Pituitary adenylate cyclase activating polypeptide (PACAP) Pituitary Adenylate Cyclase-Activating Polypeptide Rabbits Radioimmunoassay Rats Rats, Sprague-Dawley Retina - enzymology Species Specificity Swine Tissue Extracts - chemistry Vasoactive Intestinal Peptide - pharmacology Vertebrates: nervous system and sense organs |
| title | PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species |
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