Microalbuminuria and endothelial dysfunction in essential hypertension
Summary Microalbuminuria (urinary albumin excretion between 20 and 200 μg/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hyper...
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| Veröffentlicht in: | The Lancet (British edition) 1994-07, Vol.344 (8914), p.14-18 |
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| creator | Pedrinelli, R Dell'omo, G Catapano, G Giampietro, O Carmassi, F Matteucci, E Talarico, L Morale, M de Negri, F di Bello, V Melillo, E |
| description | Summary
Microalbuminuria (urinary albumin excretion between 20 and 200 μg/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hypertension and microalbuminuria without diabetes to be compared with an equal number of matched patients with essential hypertension excreting albumin in normal amounts and 10 normal controls.
The status of endothelial function was inferred from circulating von Willebrand Factor antigen (vWF), a glycoprotein secreted in greater amounts when the vascular endothelium is damaged. vWF concentrations were higher in hypertensive patients with microalbuminuria than in hypertensive patients without and controls. Individual vWF and urine albumin-excretion values were correlated (r=0·55, p |
| doi_str_mv | 10.1016/S0140-6736(94)91047-2 |
| format | Article |
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Microalbuminuria (urinary albumin excretion between 20 and 200 μg/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hypertension and microalbuminuria without diabetes to be compared with an equal number of matched patients with essential hypertension excreting albumin in normal amounts and 10 normal controls.
The status of endothelial function was inferred from circulating von Willebrand Factor antigen (vWF), a glycoprotein secreted in greater amounts when the vascular endothelium is damaged. vWF concentrations were higher in hypertensive patients with microalbuminuria than in hypertensive patients without and controls. Individual vWF and urine albumin-excretion values were correlated (r=0·55, p<0·002). Blood pressure correlated with both urinary albumin excretion and vWF. Left ventricular mass index and minimal forearm vascular resistances were comparable in patients with hypertension and higher than in controls; total and low-density lipoprotein cholesterol, triglycerides, lipoprotein-a, Factor VII, and plasminogen activator inhibitor-1 did not differ. Fibrinogen was higher and creatinine clearance lower in microalbuminurics.
Albuminuria in essential hypertension may reflect systemic dysfunction of the vascular endothelium, a structure intimately involved in permeability, haemostasis, fibrinolysis, and blood pressure control. This abnormality may have important physiopathological implications and expose these patients to increased cardiovascular risk.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(94)91047-2</identifier><identifier>PMID: 7912295</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Albuminuria ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Endothelium, Vascular - physiopathology ; Excretion ; Health risks ; Hemodynamics ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - physiopathology ; Hypertension - urine ; Lipids - blood ; Male ; Medical disorders ; Medical research ; Medical sciences ; Middle Aged ; Permeability ; von Willebrand Factor - analysis</subject><ispartof>The Lancet (British edition), 1994-07, Vol.344 (8914), p.14-18</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Jul 2, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-e6b30c54b71b0c5844b48e68a7598f3372fd0a0ae0032e589ea263f0681740a43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673694910472$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4121317$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7912295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedrinelli, R</creatorcontrib><creatorcontrib>Dell'omo, G</creatorcontrib><creatorcontrib>Catapano, G</creatorcontrib><creatorcontrib>Giampietro, O</creatorcontrib><creatorcontrib>Carmassi, F</creatorcontrib><creatorcontrib>Matteucci, E</creatorcontrib><creatorcontrib>Talarico, L</creatorcontrib><creatorcontrib>Morale, M</creatorcontrib><creatorcontrib>de Negri, F</creatorcontrib><creatorcontrib>di Bello, V</creatorcontrib><creatorcontrib>Melillo, E</creatorcontrib><title>Microalbuminuria and endothelial dysfunction in essential hypertension</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Summary
Microalbuminuria (urinary albumin excretion between 20 and 200 μg/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hypertension and microalbuminuria without diabetes to be compared with an equal number of matched patients with essential hypertension excreting albumin in normal amounts and 10 normal controls.
The status of endothelial function was inferred from circulating von Willebrand Factor antigen (vWF), a glycoprotein secreted in greater amounts when the vascular endothelium is damaged. vWF concentrations were higher in hypertensive patients with microalbuminuria than in hypertensive patients without and controls. Individual vWF and urine albumin-excretion values were correlated (r=0·55, p<0·002). Blood pressure correlated with both urinary albumin excretion and vWF. Left ventricular mass index and minimal forearm vascular resistances were comparable in patients with hypertension and higher than in controls; total and low-density lipoprotein cholesterol, triglycerides, lipoprotein-a, Factor VII, and plasminogen activator inhibitor-1 did not differ. Fibrinogen was higher and creatinine clearance lower in microalbuminurics.
Albuminuria in essential hypertension may reflect systemic dysfunction of the vascular endothelium, a structure intimately involved in permeability, haemostasis, fibrinolysis, and blood pressure control. This abnormality may have important physiopathological implications and expose these patients to increased cardiovascular risk.</description><subject>Albuminuria</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Excretion</subject><subject>Health risks</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - urine</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Permeability</subject><subject>von Willebrand Factor - analysis</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkEtLHEEUhYsQMaPmJwhNCGIWbW49uh4rEdEoKC5iILuiuvo2lvRUT6q6A_PvrXGGWWST1Vmc714OHyGnFC4oUPn9J1ABtVRcnhvxzVAQqmYfyIIKJepGqN8fyWKPfCJHOb8CgJDQHJJDZShjplmQ28fg0-iGdl6GOKfgKhe7CmM3Ti84BDdU3Tr3c_RTGGMVYoU5Y5w2xct6hWnCmEtzQg56N2T8vMtj8uv25vn6rn54-nF_ffVQe6HZVKNsOfhGtIq2JbUQrdAotVON0T3nivUdOHAIwBk22qBjkvcgNVUCnODH5Gz7d5XGPzPmyS5D9jgMLuI4Z6tko4RWuoBf_gFfxznFss1SY4BLxUyBmi1UFOScsLerFJYurS0Fu5Fs3yXbjUFrhH2XbFm5O909n9sldvurndXSf931Lns39MlFH_IeE5RRTlXBLrcYFmN_AyabfcDosQsJ_WS7MfxnyBsDB5f9</recordid><startdate>19940702</startdate><enddate>19940702</enddate><creator>Pedrinelli, R</creator><creator>Dell'omo, G</creator><creator>Catapano, G</creator><creator>Giampietro, O</creator><creator>Carmassi, F</creator><creator>Matteucci, E</creator><creator>Talarico, L</creator><creator>Morale, M</creator><creator>de Negri, F</creator><creator>di Bello, V</creator><creator>Melillo, E</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19940702</creationdate><title>Microalbuminuria and endothelial dysfunction in essential hypertension</title><author>Pedrinelli, R ; Dell'omo, G ; Catapano, G ; Giampietro, O ; Carmassi, F ; Matteucci, E ; Talarico, L ; Morale, M ; de Negri, F ; di Bello, V ; Melillo, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-e6b30c54b71b0c5844b48e68a7598f3372fd0a0ae0032e589ea263f0681740a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Albuminuria</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Excretion</topic><topic>Health risks</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - urine</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical disorders</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Permeability</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedrinelli, R</creatorcontrib><creatorcontrib>Dell'omo, G</creatorcontrib><creatorcontrib>Catapano, G</creatorcontrib><creatorcontrib>Giampietro, O</creatorcontrib><creatorcontrib>Carmassi, F</creatorcontrib><creatorcontrib>Matteucci, E</creatorcontrib><creatorcontrib>Talarico, L</creatorcontrib><creatorcontrib>Morale, M</creatorcontrib><creatorcontrib>de 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edition)</jtitle><addtitle>Lancet</addtitle><date>1994-07-02</date><risdate>1994</risdate><volume>344</volume><issue>8914</issue><spage>14</spage><epage>18</epage><pages>14-18</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary
Microalbuminuria (urinary albumin excretion between 20 and 200 μg/min) and endothelial dysfunction coexist in patients with essential hypertension. To evaluate whether the two phenomena are related and the determinants of that association, we recruited 10 untreated males with essential hypertension and microalbuminuria without diabetes to be compared with an equal number of matched patients with essential hypertension excreting albumin in normal amounts and 10 normal controls.
The status of endothelial function was inferred from circulating von Willebrand Factor antigen (vWF), a glycoprotein secreted in greater amounts when the vascular endothelium is damaged. vWF concentrations were higher in hypertensive patients with microalbuminuria than in hypertensive patients without and controls. Individual vWF and urine albumin-excretion values were correlated (r=0·55, p<0·002). Blood pressure correlated with both urinary albumin excretion and vWF. Left ventricular mass index and minimal forearm vascular resistances were comparable in patients with hypertension and higher than in controls; total and low-density lipoprotein cholesterol, triglycerides, lipoprotein-a, Factor VII, and plasminogen activator inhibitor-1 did not differ. Fibrinogen was higher and creatinine clearance lower in microalbuminurics.
Albuminuria in essential hypertension may reflect systemic dysfunction of the vascular endothelium, a structure intimately involved in permeability, haemostasis, fibrinolysis, and blood pressure control. This abnormality may have important physiopathological implications and expose these patients to increased cardiovascular risk.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7912295</pmid><doi>10.1016/S0140-6736(94)91047-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1994-07, Vol.344 (8914), p.14-18 |
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| subjects | Albuminuria Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood pressure Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Endothelium, Vascular - physiopathology Excretion Health risks Hemodynamics Humans Hypertension Hypertension - blood Hypertension - physiopathology Hypertension - urine Lipids - blood Male Medical disorders Medical research Medical sciences Middle Aged Permeability von Willebrand Factor - analysis |
| title | Microalbuminuria and endothelial dysfunction in essential hypertension |
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