Antidepressive drugs can change the affinity of [ 3H]imipramine and [ 3H]paroxetine binding to platelet and neuronal membranes

Serotonin transport in synapses and platelets is inhibited by tricyclic antidepressants as well as by more selective transport inhibitors. This inhibition is hypothesized to be of importance for the psychotropic effect, although it is known that some new antidepressants do not possess this transport...

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Veröffentlicht in:	European journal of pharmacology 1985-12, Vol.119 (1), p.1-8
Hauptverfasser:	Plenge, Per, Mellerup, Erling T.
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 3H]Paroxetine Animals Antidepressive Agents - metabolism Antidepressive Agents - pharmacology Binding Binding Sites - drug effects Binding, Competitive - drug effects Biological and medical sciences Blood Platelets - metabolism Brain - metabolism Brain Antidepressive drugs Cell Membrane - metabolism Citalopram Imipramine Imipramine - metabolism In Vitro Techniques Kinetics Medical sciences Neuropharmacology Paroxetine Pharmacology. Drug treatments Piperidines - metabolism Platelets Propylamines - metabolism Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Serotonin - metabolism Serotonin Antagonists - metabolism Serotonin transport complex Synaptic Membranes - metabolism
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