Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis
purpose: As cocaine abuse has become widespread, catastrophic cocaine-associated cardiovascular events have been noted with increasing frequency. Although these incidents are thought to be caused by drug-induced vasoconstriction and/or arterial thrombosis, the influence of cocaine on the plasma cons...
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| Veröffentlicht in: | The American journal of medicine 1994-06, Vol.96 (6), p.492-496 |
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| creator | Moliterno, David J. Lange, Richard A. Gerard, Robert D. Willard, John E. Lackner, Carolin Hillis, L.David |
| description | purpose: As cocaine abuse has become widespread, catastrophic cocaine-associated cardiovascular events have been noted with increasing frequency. Although these incidents are thought to be caused by drug-induced vasoconstriction and/or arterial thrombosis, the influence of cocaine on the plasma constituents involved in endogenous thrombosis and thrombolysis has not been characterized.
patients and methods: In 22 patients (8 men, 14 women, ages 32 to 62 years) undergoing cardiac catheterization, blood samples were procured before and 15 minutes after the administration of intranasal saline (n = 8, controls) or cocaine, 2 mg/kg (n = 14), and the plasma concentrations of fibrinogen, plasminogen, and lipoprotein(a), as well as tissue plasminogen activator activity and plasminogen activator inhibitor (PAI-1) activity, were measured.
results: No variable changed with the use of intranasal saline, whereas the use of cocaine resulted in an increase in PAI-1 activity (0.48 + 0.06 [mean + SD] nmol/L at baseline, 0.53 + 0.05 nmol/L after cocaine,
P = 0.011).
conclusion: Intranasal cocaine administration is associated with an increase in plasma PAI-1 activity. This may be important in recreational users of cocaine who experience vascular thrombosis. |
| doi_str_mv | 10.1016/0002-9343(94)90087-6 |
| format | Article |
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patients and methods: In 22 patients (8 men, 14 women, ages 32 to 62 years) undergoing cardiac catheterization, blood samples were procured before and 15 minutes after the administration of intranasal saline (n = 8, controls) or cocaine, 2 mg/kg (n = 14), and the plasma concentrations of fibrinogen, plasminogen, and lipoprotein(a), as well as tissue plasminogen activator activity and plasminogen activator inhibitor (PAI-1) activity, were measured.
results: No variable changed with the use of intranasal saline, whereas the use of cocaine resulted in an increase in PAI-1 activity (0.48 + 0.06 [mean + SD] nmol/L at baseline, 0.53 + 0.05 nmol/L after cocaine,
P = 0.011).
conclusion: Intranasal cocaine administration is associated with an increase in plasma PAI-1 activity. This may be important in recreational users of cocaine who experience vascular thrombosis.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(94)90087-6</identifier><identifier>PMID: 8017445</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Intranasal ; Adult ; Biological and medical sciences ; Blood Coagulation - drug effects ; Blood Coagulation Factors - metabolism ; Blood vessels ; Chi-Square Distribution ; Cocaine ; Cocaine - administration & dosage ; Cocaine - pharmacology ; Drug addictions ; Female ; Fibrinogen - metabolism ; Humans ; Lipoprotein(a) - blood ; Male ; Medical disorders ; Medical research ; Medical sciences ; Middle Aged ; Plasminogen - metabolism ; Plasminogen Activator Inhibitor 1 - blood ; Tissue Plasminogen Activator - blood ; Toxicology</subject><ispartof>The American journal of medicine, 1994-06, Vol.96 (6), p.492-496</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Jun 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-1d44cc71eca44f3c9300bfba1e6f1265a7c34f9c88afb56e1005b7bca3d6fd423</citedby><cites>FETCH-LOGICAL-c444t-1d44cc71eca44f3c9300bfba1e6f1265a7c34f9c88afb56e1005b7bca3d6fd423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(94)90087-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4126855$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8017445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moliterno, David J.</creatorcontrib><creatorcontrib>Lange, Richard A.</creatorcontrib><creatorcontrib>Gerard, Robert D.</creatorcontrib><creatorcontrib>Willard, John E.</creatorcontrib><creatorcontrib>Lackner, Carolin</creatorcontrib><creatorcontrib>Hillis, L.David</creatorcontrib><title>Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>purpose: As cocaine abuse has become widespread, catastrophic cocaine-associated cardiovascular events have been noted with increasing frequency. Although these incidents are thought to be caused by drug-induced vasoconstriction and/or arterial thrombosis, the influence of cocaine on the plasma constituents involved in endogenous thrombosis and thrombolysis has not been characterized.
patients and methods: In 22 patients (8 men, 14 women, ages 32 to 62 years) undergoing cardiac catheterization, blood samples were procured before and 15 minutes after the administration of intranasal saline (n = 8, controls) or cocaine, 2 mg/kg (n = 14), and the plasma concentrations of fibrinogen, plasminogen, and lipoprotein(a), as well as tissue plasminogen activator activity and plasminogen activator inhibitor (PAI-1) activity, were measured.
results: No variable changed with the use of intranasal saline, whereas the use of cocaine resulted in an increase in PAI-1 activity (0.48 + 0.06 [mean + SD] nmol/L at baseline, 0.53 + 0.05 nmol/L after cocaine,
P = 0.011).
conclusion: Intranasal cocaine administration is associated with an increase in plasma PAI-1 activity. This may be important in recreational users of cocaine who experience vascular thrombosis.</description><subject>Administration, Intranasal</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood Coagulation Factors - metabolism</subject><subject>Blood vessels</subject><subject>Chi-Square Distribution</subject><subject>Cocaine</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine - pharmacology</subject><subject>Drug addictions</subject><subject>Female</subject><subject>Fibrinogen - metabolism</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Plasminogen - metabolism</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Toxicology</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEQgIMo67j6DxQaEdFDa9J5dS4LsvhYWPCi55CuJG6W7mRM0sr-e9POOAcPegpV9VVRqQ-hpwS_IZiItxjjoVeU0VeKvVYYj7IX99COcM57ScRwH-1OyEP0qJTbFmLFxRk6GzGRjPEdWq6in1cXwXXJdyHWbKIpZu4ggQmxZWO3n01ZTMvEUkNtcC2dKSVBMNXZ7meoN52LNn1zMa2lqzc5LVMqoVHR_gnnu5Z4jB54Mxf35Pieo68f3n-5_NRff_54dfnuugfGWO2JZQxAEgeGMU9BUYwnPxnihCeD4EYCZV7BOBo_ceEIxnySExhqhbdsoOfo5WHuPqfvqytVL6GAm2cTXVtRS8El5YT_FyRCjGLEsoHP_wJv05pj-4Qe6ECZkoo2iB0gyKmU7Lze57CYfKcJ1pszvQnRmxCtmP7tTIvW9uw4e50WZ09NR0mt_uJYNwXM7JsiCOWEsXaSkW_YxQFz7bI_gsu6QNjM2pAdVG1T-PcevwA8L7Sa</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Moliterno, David J.</creator><creator>Lange, Richard A.</creator><creator>Gerard, Robert D.</creator><creator>Willard, John E.</creator><creator>Lackner, Carolin</creator><creator>Hillis, L.David</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis</title><author>Moliterno, David J. ; Lange, Richard A. ; Gerard, Robert D. ; Willard, John E. ; Lackner, Carolin ; Hillis, L.David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-1d44cc71eca44f3c9300bfba1e6f1265a7c34f9c88afb56e1005b7bca3d6fd423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Intranasal</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood Coagulation Factors - metabolism</topic><topic>Blood vessels</topic><topic>Chi-Square Distribution</topic><topic>Cocaine</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine - pharmacology</topic><topic>Drug addictions</topic><topic>Female</topic><topic>Fibrinogen - metabolism</topic><topic>Humans</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Medical disorders</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Plasminogen - metabolism</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Tissue Plasminogen Activator - blood</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moliterno, David J.</creatorcontrib><creatorcontrib>Lange, Richard A.</creatorcontrib><creatorcontrib>Gerard, Robert D.</creatorcontrib><creatorcontrib>Willard, John E.</creatorcontrib><creatorcontrib>Lackner, Carolin</creatorcontrib><creatorcontrib>Hillis, L.David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moliterno, David J.</au><au>Lange, Richard A.</au><au>Gerard, Robert D.</au><au>Willard, John E.</au><au>Lackner, Carolin</au><au>Hillis, L.David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>96</volume><issue>6</issue><spage>492</spage><epage>496</epage><pages>492-496</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>purpose: As cocaine abuse has become widespread, catastrophic cocaine-associated cardiovascular events have been noted with increasing frequency. Although these incidents are thought to be caused by drug-induced vasoconstriction and/or arterial thrombosis, the influence of cocaine on the plasma constituents involved in endogenous thrombosis and thrombolysis has not been characterized.
patients and methods: In 22 patients (8 men, 14 women, ages 32 to 62 years) undergoing cardiac catheterization, blood samples were procured before and 15 minutes after the administration of intranasal saline (n = 8, controls) or cocaine, 2 mg/kg (n = 14), and the plasma concentrations of fibrinogen, plasminogen, and lipoprotein(a), as well as tissue plasminogen activator activity and plasminogen activator inhibitor (PAI-1) activity, were measured.
results: No variable changed with the use of intranasal saline, whereas the use of cocaine resulted in an increase in PAI-1 activity (0.48 + 0.06 [mean + SD] nmol/L at baseline, 0.53 + 0.05 nmol/L after cocaine,
P = 0.011).
conclusion: Intranasal cocaine administration is associated with an increase in plasma PAI-1 activity. This may be important in recreational users of cocaine who experience vascular thrombosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8017445</pmid><doi>10.1016/0002-9343(94)90087-6</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Intranasal Adult Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation Factors - metabolism Blood vessels Chi-Square Distribution Cocaine Cocaine - administration & dosage Cocaine - pharmacology Drug addictions Female Fibrinogen - metabolism Humans Lipoprotein(a) - blood Male Medical disorders Medical research Medical sciences Middle Aged Plasminogen - metabolism Plasminogen Activator Inhibitor 1 - blood Tissue Plasminogen Activator - blood Toxicology |
| title | Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis |
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