Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
MANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies 1–10 have shown that one or more of the Janus kinase family m...
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| Veröffentlicht in: | Nature (London) 1994-07, Vol.370 (6485), p.153-157 |
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| creator | Witthuhn, Bruce A Silvennoinen, Olli Miura, Osamu Lai, Koon Siew Cwik, Christopher Liu, Edison T Ihle, James N |
| description | MANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies
1–10
have shown that one or more of the Janus kinase family members (Jaks) associate with cytokine receptors and are tyrosine phosphorylated and activated following ligand binding. Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak-3 is activated in the responses to interleukin-2 and interleukin–4 in T cells and myeloid cells. Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor β-chain, but does not require the acidic domain that is required for association and activation of Src family kinases. |
| doi_str_mv | 10.1038/370153a0 |
| format | Article |
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1–10
have shown that one or more of the Janus kinase family members (Jaks) associate with cytokine receptors and are tyrosine phosphorylated and activated following ligand binding. Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak-3 is activated in the responses to interleukin-2 and interleukin–4 in T cells and myeloid cells. Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor β-chain, but does not require the acidic domain that is required for association and activation of Src family kinases.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/370153a0</identifier><identifier>PMID: 8022486</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Biochemistry ; Biological and medical sciences ; Bone Marrow - physiology ; Bone Marrow Cells ; Cell Line ; Cytokines - physiology ; Enzyme Activation - physiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humanities and Social Sciences ; Immunobiology ; Interleukin-2 - physiology ; Interleukin-4 - physiology ; Janus Kinase 3 ; letter ; Lymphocytes - physiology ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Mice ; Molecular Sequence Data ; multidisciplinary ; Organ Specificity ; Precipitin Tests ; Protein-Tyrosine Kinases - physiology ; Science ; Science (multidisciplinary) ; Sequence Homology, Amino Acid ; Signal Transduction - physiology</subject><ispartof>Nature (London), 1994-07, Vol.370 (6485), p.153-157</ispartof><rights>Springer Nature Limited 1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Jul 14, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3370-465b4f20f60babc511351a58e5aca446b320cf308d6bdffcbfcbb73efeebff3a3</citedby><cites>FETCH-LOGICAL-c3370-465b4f20f60babc511351a58e5aca446b320cf308d6bdffcbfcbb73efeebff3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/370153a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/370153a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4155977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8022486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Witthuhn, Bruce A</creatorcontrib><creatorcontrib>Silvennoinen, Olli</creatorcontrib><creatorcontrib>Miura, Osamu</creatorcontrib><creatorcontrib>Lai, Koon Siew</creatorcontrib><creatorcontrib>Cwik, Christopher</creatorcontrib><creatorcontrib>Liu, Edison T</creatorcontrib><creatorcontrib>Ihle, James N</creatorcontrib><title>Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>MANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies
1–10
have shown that one or more of the Janus kinase family members (Jaks) associate with cytokine receptors and are tyrosine phosphorylated and activated following ligand binding. Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak-3 is activated in the responses to interleukin-2 and interleukin–4 in T cells and myeloid cells. Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor β-chain, but does not require the acidic domain that is required for association and activation of Src family kinases.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - physiology</subject><subject>Bone Marrow Cells</subject><subject>Cell Line</subject><subject>Cytokines - physiology</subject><subject>Enzyme Activation - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humanities and Social Sciences</subject><subject>Immunobiology</subject><subject>Interleukin-2 - physiology</subject><subject>Interleukin-4 - physiology</subject><subject>Janus Kinase 3</subject><subject>letter</subject><subject>Lymphocytes - physiology</subject><subject>Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Organ Specificity</subject><subject>Precipitin Tests</subject><subject>Protein-Tyrosine Kinases - physiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction - physiology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV9rFDEUxYModVsFv4ASRMQ-jCaTv32UUmtLwRd9HpLMzTZtJrMmM4X99mbcdYUiCCEJ9_w49yQXoVeUfKSE6U9MESqYIU_QinIlGy61eopWhLS6IZrJ5-i4lDtCiKCKH6EjTdqWa7lC4So9jPEBBkgTHj2ebgFfm_uG1T3NBd-HZArgkHAJ62RiDGmN7bYWJsgR5qoX3GKTeswXKm6Hze0Y-t-VYQtxuTuIsbxAz7yJBV7uzxP048vF9_Ovzc23y6vzzzeNY_UVNbmw3LfES2KNdYJSJqgRGoRxhnNpWUucZ0T30vbeO1uXVQw8gPWeGXaC3u98N3n8OUOZuiGUJYFJMM6lU1Ioxs_a_4JU6jOlBK_g20fg3Tjn-hmla0mNxClf3D7sIJfHUjL4bpPDYPK2o6RbZtT9mVFFX-_9ZjtAfwD3Q6n6u71uijPRZ5NcKAeMUyFqsIqd7rBSlbSG_DfWP1q-2bHJTHOGg9cB-AWW9q8w</recordid><startdate>19940714</startdate><enddate>19940714</enddate><creator>Witthuhn, Bruce A</creator><creator>Silvennoinen, Olli</creator><creator>Miura, Osamu</creator><creator>Lai, Koon Siew</creator><creator>Cwik, Christopher</creator><creator>Liu, Edison T</creator><creator>Ihle, James N</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19940714</creationdate><title>Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells</title><author>Witthuhn, Bruce A ; 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Witthuhn, Bruce A</au><au>Silvennoinen, Olli</au><au>Miura, Osamu</au><au>Lai, Koon Siew</au><au>Cwik, Christopher</au><au>Liu, Edison T</au><au>Ihle, James N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1994-07-14</date><risdate>1994</risdate><volume>370</volume><issue>6485</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>MANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies
1–10
have shown that one or more of the Janus kinase family members (Jaks) associate with cytokine receptors and are tyrosine phosphorylated and activated following ligand binding. Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak-3 is activated in the responses to interleukin-2 and interleukin–4 in T cells and myeloid cells. Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor β-chain, but does not require the acidic domain that is required for association and activation of Src family kinases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8022486</pmid><doi>10.1038/370153a0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nature (London), 1994-07, Vol.370 (6485), p.153-157 |
| issn | 0028-0836 1476-4687 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Animals Biochemistry Biological and medical sciences Bone Marrow - physiology Bone Marrow Cells Cell Line Cytokines - physiology Enzyme Activation - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humanities and Social Sciences Immunobiology Interleukin-2 - physiology Interleukin-4 - physiology Janus Kinase 3 letter Lymphocytes - physiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Molecular Sequence Data multidisciplinary Organ Specificity Precipitin Tests Protein-Tyrosine Kinases - physiology Science Science (multidisciplinary) Sequence Homology, Amino Acid Signal Transduction - physiology |
| title | Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells |
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