Responses of feline raphespinal neurons to urinary bladder distension
Effects of distending the urinary bladder were studied on extracellular activity of 77 raphespinal neurons in 19 α-chloralose anesthetized cats. Neurons were activated antidromically from thoracic spinal cord; recording sites were located in nucleus raphe magnus (NRM). Mean conduction velocity was 4...
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| Veröffentlicht in: | Journal of the autonomic nervous system 1994-05, Vol.47 (3), p.213-224 |
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| container_title | Journal of the autonomic nervous system |
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| creator | Chandler, Margaret J. Oh, Uh-Taek Hobbs, Stuart F. Foreman, Robert D. |
| description | Effects of distending the urinary bladder were studied on extracellular activity of 77 raphespinal neurons in 19 α-chloralose anesthetized cats. Neurons were activated antidromically from thoracic spinal cord; recording sites were located in nucleus raphe magnus (NRM). Mean conduction velocity was 48 ± 2 m/s. Urinary bladder distension (UBD) increased activity in 12 cells and decreased activity in 17 cells. Spontaneous bladder contractions also affected activity in raphespinal neurons responsive to UBD. Noxious pinch stimulus applied to proximal hindlimbs or forelimbs either increased or decreased activity in 28 raphespinal neurons. No cells were excited both by UBD and pinching of skin and deep tissues of the limbs. Thus, excitatory viscerosomatic convergence was not observed with the stimuli tested in raphespinal neurons examined in this study. Urinary bladder input to descending projection neurons in NRM might participate in descending modulation of dorsal horn neurons. In addition, micturition reflexes might be affected by urinary bladder input to these neurons. |
| doi_str_mv | 10.1016/0165-1838(94)90182-1 |
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Neurons were activated antidromically from thoracic spinal cord; recording sites were located in nucleus raphe magnus (NRM). Mean conduction velocity was 48 ± 2 m/s. Urinary bladder distension (UBD) increased activity in 12 cells and decreased activity in 17 cells. Spontaneous bladder contractions also affected activity in raphespinal neurons responsive to UBD. Noxious pinch stimulus applied to proximal hindlimbs or forelimbs either increased or decreased activity in 28 raphespinal neurons. No cells were excited both by UBD and pinching of skin and deep tissues of the limbs. Thus, excitatory viscerosomatic convergence was not observed with the stimuli tested in raphespinal neurons examined in this study. Urinary bladder input to descending projection neurons in NRM might participate in descending modulation of dorsal horn neurons. In addition, micturition reflexes might be affected by urinary bladder input to these neurons.</description><identifier>ISSN: 0165-1838</identifier><identifier>EISSN: 1872-7476</identifier><identifier>DOI: 10.1016/0165-1838(94)90182-1</identifier><identifier>PMID: 8014380</identifier><identifier>CODEN: JASYDS</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Afferent Pathways - physiology ; Animals ; Biological and medical sciences ; Cats ; Descending spinal pathway ; Evoked Potentials ; Forelimb - innervation ; Fundamental and applied biological sciences. Psychology ; Hindlimb - innervation ; Neural Conduction ; Neurons - physiology ; Neurons, Afferent - physiology ; Nucleus raphe magnus ; Pain - physiopathology ; Raphe Nuclei - physiology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal Cord - physiology ; Stress, Mechanical ; Touch - physiology ; Urinary bladder ; Urinary Bladder - innervation ; Urination - physiology ; Vertebrates: nervous system and sense organs ; Viscerosomatic convergence</subject><ispartof>Journal of the autonomic nervous system, 1994-05, Vol.47 (3), p.213-224</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-ae568ab1197f46a56fc149e5847c7ee71e32be32016786a68ac1fc09fb49e62f3</citedby><cites>FETCH-LOGICAL-c417t-ae568ab1197f46a56fc149e5847c7ee71e32be32016786a68ac1fc09fb49e62f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3948732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8014380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandler, Margaret J.</creatorcontrib><creatorcontrib>Oh, Uh-Taek</creatorcontrib><creatorcontrib>Hobbs, Stuart F.</creatorcontrib><creatorcontrib>Foreman, Robert D.</creatorcontrib><title>Responses of feline raphespinal neurons to urinary bladder distension</title><title>Journal of the autonomic nervous system</title><addtitle>J Auton Nerv Syst</addtitle><description>Effects of distending the urinary bladder were studied on extracellular activity of 77 raphespinal neurons in 19 α-chloralose anesthetized cats. Neurons were activated antidromically from thoracic spinal cord; recording sites were located in nucleus raphe magnus (NRM). Mean conduction velocity was 48 ± 2 m/s. Urinary bladder distension (UBD) increased activity in 12 cells and decreased activity in 17 cells. Spontaneous bladder contractions also affected activity in raphespinal neurons responsive to UBD. Noxious pinch stimulus applied to proximal hindlimbs or forelimbs either increased or decreased activity in 28 raphespinal neurons. No cells were excited both by UBD and pinching of skin and deep tissues of the limbs. Thus, excitatory viscerosomatic convergence was not observed with the stimuli tested in raphespinal neurons examined in this study. Urinary bladder input to descending projection neurons in NRM might participate in descending modulation of dorsal horn neurons. In addition, micturition reflexes might be affected by urinary bladder input to these neurons.</description><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Descending spinal pathway</subject><subject>Evoked Potentials</subject><subject>Forelimb - innervation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hindlimb - innervation</subject><subject>Neural Conduction</subject><subject>Neurons - physiology</subject><subject>Neurons, Afferent - physiology</subject><subject>Nucleus raphe magnus</subject><subject>Pain - physiopathology</subject><subject>Raphe Nuclei - physiology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal Cord - physiology</subject><subject>Stress, Mechanical</subject><subject>Touch - physiology</subject><subject>Urinary bladder</subject><subject>Urinary Bladder - innervation</subject><subject>Urination - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Viscerosomatic convergence</subject><issn>0165-1838</issn><issn>1872-7476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoSbdJ_kEKOoTQHtxobFkfl0AI6QcECiE5C1keERWvtJXsQv99tNllj-lhEMz7zDB6CDkH9hUYiKtafQOqU581_6IZqLaBI7ICJdtGcinekdUB-UA-lvKbMZBMq2NyrBjwTrEVuXvAskmxYKHJU49TiEiz3TzXdoh2ohGXXHM6J7rk2sn_6DDZccRMx1BmjCWkeEreezsVPNu_J-Tp293j7Y_m_tf3n7c3943jIOfGYi-UHQC09FzYXngHXGOvuHQSUQJ27VCrni2VsJV14B3TfqiUaH13Qi53ezc5_VmwzGYdisNpshHTUowUvWyllv8FQWgOjLMK8h3ociolozebHNb1lwaY2Wo2W4dm69Bobl41G6hjn_b7l2GN42Fo77XmF_vcFmcnn210oRywTnMlu7Zi1zsMq7S_AbMpLmB0OIaMbjZjCm_f8QI4FZiv</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Chandler, Margaret J.</creator><creator>Oh, Uh-Taek</creator><creator>Hobbs, Stuart F.</creator><creator>Foreman, Robert D.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Responses of feline raphespinal neurons to urinary bladder distension</title><author>Chandler, Margaret J. ; Oh, Uh-Taek ; Hobbs, Stuart F. ; Foreman, Robert D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-ae568ab1197f46a56fc149e5847c7ee71e32be32016786a68ac1fc09fb49e62f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Descending spinal pathway</topic><topic>Evoked Potentials</topic><topic>Forelimb - innervation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hindlimb - innervation</topic><topic>Neural Conduction</topic><topic>Neurons - physiology</topic><topic>Neurons, Afferent - physiology</topic><topic>Nucleus raphe magnus</topic><topic>Pain - physiopathology</topic><topic>Raphe Nuclei - physiology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal Cord - physiology</topic><topic>Stress, Mechanical</topic><topic>Touch - physiology</topic><topic>Urinary bladder</topic><topic>Urinary Bladder - innervation</topic><topic>Urination - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Viscerosomatic convergence</topic><toplevel>online_resources</toplevel><creatorcontrib>Chandler, Margaret J.</creatorcontrib><creatorcontrib>Oh, Uh-Taek</creatorcontrib><creatorcontrib>Hobbs, Stuart F.</creatorcontrib><creatorcontrib>Foreman, Robert D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the autonomic nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandler, Margaret J.</au><au>Oh, Uh-Taek</au><au>Hobbs, Stuart F.</au><au>Foreman, Robert D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responses of feline raphespinal neurons to urinary bladder distension</atitle><jtitle>Journal of the autonomic nervous system</jtitle><addtitle>J Auton Nerv Syst</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>47</volume><issue>3</issue><spage>213</spage><epage>224</epage><pages>213-224</pages><issn>0165-1838</issn><eissn>1872-7476</eissn><coden>JASYDS</coden><abstract>Effects of distending the urinary bladder were studied on extracellular activity of 77 raphespinal neurons in 19 α-chloralose anesthetized cats. Neurons were activated antidromically from thoracic spinal cord; recording sites were located in nucleus raphe magnus (NRM). Mean conduction velocity was 48 ± 2 m/s. Urinary bladder distension (UBD) increased activity in 12 cells and decreased activity in 17 cells. Spontaneous bladder contractions also affected activity in raphespinal neurons responsive to UBD. Noxious pinch stimulus applied to proximal hindlimbs or forelimbs either increased or decreased activity in 28 raphespinal neurons. No cells were excited both by UBD and pinching of skin and deep tissues of the limbs. Thus, excitatory viscerosomatic convergence was not observed with the stimuli tested in raphespinal neurons examined in this study. Urinary bladder input to descending projection neurons in NRM might participate in descending modulation of dorsal horn neurons. 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| ispartof | Journal of the autonomic nervous system, 1994-05, Vol.47 (3), p.213-224 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Afferent Pathways - physiology Animals Biological and medical sciences Cats Descending spinal pathway Evoked Potentials Forelimb - innervation Fundamental and applied biological sciences. Psychology Hindlimb - innervation Neural Conduction Neurons - physiology Neurons, Afferent - physiology Nucleus raphe magnus Pain - physiopathology Raphe Nuclei - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - physiology Stress, Mechanical Touch - physiology Urinary bladder Urinary Bladder - innervation Urination - physiology Vertebrates: nervous system and sense organs Viscerosomatic convergence |
| title | Responses of feline raphespinal neurons to urinary bladder distension |
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