Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies

The antihypertensive drug dihydralazine may, on rare occasions, cause immunoallergic hepatitis characterized by anti-cytochrome P450 (P450)1A2 autoantibodies. To understand the first steps leading to this immune reaction, we studied the covalent binding fo dihydralazine metabolites to microsomes fro...

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Veröffentlicht in:	Molecular pharmacology 1994-06, Vol.45 (6), p.1287-1295
Hauptverfasser:	Bourdi, M, Tinel, M, Beaune, P H, Pessayre, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arylamine N-Acetyltransferase - metabolism Autoantibodies - biosynthesis Binding Sites Biotransformation Blotting, Western Carbon Monoxide - metabolism Cytochrome P-450 Enzyme System - immunology Cytochrome P-450 Enzyme System - metabolism Dihydralazine - metabolism Heme - metabolism Iron - metabolism Isoenzymes - immunology Isoenzymes - metabolism Light Male Microsomes, Liver - enzymology Microsomes, Liver - metabolism NADP - biosynthesis NADP - metabolism Rats Rats, Sprague-Dawley
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