Effect of Calcium Channel Blockers on Adrenergic and Nonadrenergic Vascular Responses in Man
There is evidence that responses mediated via α adrenoceptors are dependent on calcium fluxes and it has been suggested that the α2 adrenoceptor is particularly associated with the increased entry of extracellular calcium ions, which is preferentially antagonised by calcium channel blocking drugs. T...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1985-11, Vol.7 (6), p.1166-1170 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Pasanisi, Fabrizio Elliott, Henry L Meredith, Peter A Sumner, David J Reid, John L |
| description | There is evidence that responses mediated via α adrenoceptors are dependent on calcium fluxes and it has been suggested that the α2 adrenoceptor is particularly associated with the increased entry of extracellular calcium ions, which is preferentially antagonised by calcium channel blocking drugs. This study investigates in normotensive men the effects of calcium antagonism with verapamil and the dihydropyridine nisoldipine on the pressor responses to adrenergic and nonadrenergic vasoconstriction. Phenylephrine and alphamethylnoradrenaline were intravenously infused to assess respectively α1, and α2 adrenoceptor-mediated peripheral vascular responsiveness and angiotensin II was used to assess nonadrenergic responsiveness. After 4 days oral treatment, both verapamil and nisoldipine significantly attenuated the responses to angiotensin II with three- to fivefold rightward shifts of the mean pressor dose–response curves. Rightward shifts of comparable magnitude were obtained for phenylephrine but with alphamethylnoradrenaline, although the overall trend was similar, only nisoldipine caused a significant twofold rightward shift. These data demonstrate, in humans, that peripheral vascular adrenergic responses mediated via both α1 and α2 adrenoceptors are affected by calcium channel blocking drugs. There was no evidence that this effect was specifically linked to the α2 adrenoceptor. |
| doi_str_mv | 10.1097/00005344-198511000-00024 |
| format | Article |
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This study investigates in normotensive men the effects of calcium antagonism with verapamil and the dihydropyridine nisoldipine on the pressor responses to adrenergic and nonadrenergic vasoconstriction. Phenylephrine and alphamethylnoradrenaline were intravenously infused to assess respectively α1, and α2 adrenoceptor-mediated peripheral vascular responsiveness and angiotensin II was used to assess nonadrenergic responsiveness. After 4 days oral treatment, both verapamil and nisoldipine significantly attenuated the responses to angiotensin II with three- to fivefold rightward shifts of the mean pressor dose–response curves. Rightward shifts of comparable magnitude were obtained for phenylephrine but with alphamethylnoradrenaline, although the overall trend was similar, only nisoldipine caused a significant twofold rightward shift. These data demonstrate, in humans, that peripheral vascular adrenergic responses mediated via both α1 and α2 adrenoceptors are affected by calcium channel blocking drugs. There was no evidence that this effect was specifically linked to the α2 adrenoceptor.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198511000-00024</identifier><identifier>PMID: 2418305</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Adult ; Angiotensin II - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Calcium Channel Blockers - pharmacology ; Cardiovascular system ; Dose-Response Relationship, Drug ; Hemodynamics - drug effects ; Humans ; Male ; Medical sciences ; Nifedipine - analogs & derivatives ; Nifedipine - pharmacology ; Nisoldipine ; Norepinephrine - physiology ; Normetanephrine - pharmacology ; Pharmacology. Drug treatments ; Phenylephrine - pharmacology ; Random Allocation ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, alpha - physiology ; Vasodilator agents. Cerebral vasodilators ; Verapamil - pharmacology</subject><ispartof>Journal of cardiovascular pharmacology, 1985-11, Vol.7 (6), p.1166-1170</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4344-142351d435d26d56d9fc64d48f234e8fe289a1460f31aded7bd67b8e6a94680c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198511000-00024$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,778,782,4597,27911,27912,65218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8721125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2418305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pasanisi, Fabrizio</creatorcontrib><creatorcontrib>Elliott, Henry L</creatorcontrib><creatorcontrib>Meredith, Peter A</creatorcontrib><creatorcontrib>Sumner, David J</creatorcontrib><creatorcontrib>Reid, John L</creatorcontrib><title>Effect of Calcium Channel Blockers on Adrenergic and Nonadrenergic Vascular Responses in Man</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>There is evidence that responses mediated via α adrenoceptors are dependent on calcium fluxes and it has been suggested that the α2 adrenoceptor is particularly associated with the increased entry of extracellular calcium ions, which is preferentially antagonised by calcium channel blocking drugs. This study investigates in normotensive men the effects of calcium antagonism with verapamil and the dihydropyridine nisoldipine on the pressor responses to adrenergic and nonadrenergic vasoconstriction. Phenylephrine and alphamethylnoradrenaline were intravenously infused to assess respectively α1, and α2 adrenoceptor-mediated peripheral vascular responsiveness and angiotensin II was used to assess nonadrenergic responsiveness. After 4 days oral treatment, both verapamil and nisoldipine significantly attenuated the responses to angiotensin II with three- to fivefold rightward shifts of the mean pressor dose–response curves. Rightward shifts of comparable magnitude were obtained for phenylephrine but with alphamethylnoradrenaline, although the overall trend was similar, only nisoldipine caused a significant twofold rightward shift. These data demonstrate, in humans, that peripheral vascular adrenergic responses mediated via both α1 and α2 adrenoceptors are affected by calcium channel blocking drugs. There was no evidence that this effect was specifically linked to the α2 adrenoceptor.</description><subject>Adult</subject><subject>Angiotensin II - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cardiovascular system</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nifedipine - analogs & derivatives</subject><subject>Nifedipine - pharmacology</subject><subject>Nisoldipine</subject><subject>Norepinephrine - physiology</subject><subject>Normetanephrine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - pharmacology</subject><subject>Random Allocation</subject><subject>Receptors, Adrenergic, alpha - drug effects</subject><subject>Receptors, Adrenergic, alpha - physiology</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><subject>Verapamil - pharmacology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9vFCEQgInR1LP6J5jwYHxb5cfAso_10qpJtUlTfTIhHAzeWg5OuE3jf99t7zyfJCFkmG9mwgchlLN3nA39ezYvJQE6PhjF-Rx18xbwhCy4krIDJuRTsmBcs04A6OfkRWu_GOOgen1CTgRwI5lakB_nMaLf0RLp0iU_Thu6XLucMdEPqfhbrI2WTM9CxYz15-ipy4F-Ldn9u_nump-Sq_Qa27bkho2OmX5x-SV5Fl1q-OpwnpJvF-c3y0_d5dXHz8uzy87D4xtASMUDSBWEDkqHIXoNAUwUEtBEFGZwHDSLkruAoV8F3a8MajeANszLU_J233dby-8J285uxuYxJZexTM32WmkzGDODZg_6WlqrGO22jhtX_1jO7INY-1esPYq1j2Ln0teHGdNqg-FYeDA5598c8rMNl2J12Y_tiJlecC4eMNhjdyXtZrm3abrDatfo0m5t__et8h7C1Y61</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Pasanisi, Fabrizio</creator><creator>Elliott, Henry L</creator><creator>Meredith, Peter A</creator><creator>Sumner, David J</creator><creator>Reid, John L</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198511</creationdate><title>Effect of Calcium Channel Blockers on Adrenergic and Nonadrenergic Vascular Responses in Man</title><author>Pasanisi, Fabrizio ; Elliott, Henry L ; Meredith, Peter A ; Sumner, David J ; Reid, John L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4344-142351d435d26d56d9fc64d48f234e8fe289a1460f31aded7bd67b8e6a94680c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Angiotensin II - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cardiovascular system</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nifedipine - analogs & derivatives</topic><topic>Nifedipine - pharmacology</topic><topic>Nisoldipine</topic><topic>Norepinephrine - physiology</topic><topic>Normetanephrine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - pharmacology</topic><topic>Random Allocation</topic><topic>Receptors, Adrenergic, alpha - drug effects</topic><topic>Receptors, Adrenergic, alpha - physiology</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><topic>Verapamil - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pasanisi, Fabrizio</creatorcontrib><creatorcontrib>Elliott, Henry L</creatorcontrib><creatorcontrib>Meredith, Peter A</creatorcontrib><creatorcontrib>Sumner, David J</creatorcontrib><creatorcontrib>Reid, John L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pasanisi, Fabrizio</au><au>Elliott, Henry L</au><au>Meredith, Peter A</au><au>Sumner, David J</au><au>Reid, John L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Calcium Channel Blockers on Adrenergic and Nonadrenergic Vascular Responses in Man</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1985-11</date><risdate>1985</risdate><volume>7</volume><issue>6</issue><spage>1166</spage><epage>1170</epage><pages>1166-1170</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>There is evidence that responses mediated via α adrenoceptors are dependent on calcium fluxes and it has been suggested that the α2 adrenoceptor is particularly associated with the increased entry of extracellular calcium ions, which is preferentially antagonised by calcium channel blocking drugs. This study investigates in normotensive men the effects of calcium antagonism with verapamil and the dihydropyridine nisoldipine on the pressor responses to adrenergic and nonadrenergic vasoconstriction. Phenylephrine and alphamethylnoradrenaline were intravenously infused to assess respectively α1, and α2 adrenoceptor-mediated peripheral vascular responsiveness and angiotensin II was used to assess nonadrenergic responsiveness. After 4 days oral treatment, both verapamil and nisoldipine significantly attenuated the responses to angiotensin II with three- to fivefold rightward shifts of the mean pressor dose–response curves. Rightward shifts of comparable magnitude were obtained for phenylephrine but with alphamethylnoradrenaline, although the overall trend was similar, only nisoldipine caused a significant twofold rightward shift. These data demonstrate, in humans, that peripheral vascular adrenergic responses mediated via both α1 and α2 adrenoceptors are affected by calcium channel blocking drugs. There was no evidence that this effect was specifically linked to the α2 adrenoceptor.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>2418305</pmid><doi>10.1097/00005344-198511000-00024</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cardiovascular pharmacology, 1985-11, Vol.7 (6), p.1166-1170 |
| issn | 0160-2446 1533-4023 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult Angiotensin II - pharmacology Biological and medical sciences Blood Pressure - drug effects Calcium Channel Blockers - pharmacology Cardiovascular system Dose-Response Relationship, Drug Hemodynamics - drug effects Humans Male Medical sciences Nifedipine - analogs & derivatives Nifedipine - pharmacology Nisoldipine Norepinephrine - physiology Normetanephrine - pharmacology Pharmacology. Drug treatments Phenylephrine - pharmacology Random Allocation Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - physiology Vasodilator agents. Cerebral vasodilators Verapamil - pharmacology |
| title | Effect of Calcium Channel Blockers on Adrenergic and Nonadrenergic Vascular Responses in Man |
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