Liver fatty acid composition correlates with body fat and sex in a multigenic mouse model of obesity
To determine whether there is altered liver lipid-fraction fatty acid distribution in a multigenic obese mouse model, we examined livers from eight lean (0.2–4.2% carcass fat), seven intermediate (5.7–13.8%), and five obese (20.2–48.7%) backcross progeny [(C57BL/6J × Mus spretus) × C57BL/6J] aged 2–...
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| Veröffentlicht in: | The American journal of clinical nutrition 1994-07, Vol.60 (1), p.61-67 |
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| creator | Phinney, SD Fisler, JS Tang, AB Warden, CH |
| description | To determine whether there is altered liver lipid-fraction fatty acid distribution in a multigenic obese mouse model, we examined livers from eight lean (0.2–4.2% carcass fat), seven intermediate (5.7–13.8%), and five obese (20.2–48.7%) backcross progeny [(C57BL/6J × Mus spretus) × C57BL/6J] aged 2–3 mo. Thirteen males and seven females were fed a nonpurified stock diet. Liver lipid fractions were separated and fatty acids quantitated by thin-layer and gas chromatography. There was a significant effect of obesity on 18:2ω6 in liver phospholipids (PL), cholesteryl esters, and triglycerides. PL 18:2ω6 was negatively correlated with carcass fat (r = −0.74, P < 0.001); 20:3ω6 was elevated in PL with increased obesity (P < 0.0001), and was correlated with carcass fat (r = 0.92, P < 0.0001); and 20:4ω6 in PL did not differ with obesity status. PL 20:3ω6 and 20:4ω6 were lower in males (P < 0.01 and 0.02, respectively) than in females. We conclude that obesity and sex affect distribution of ω6 essential fatty acids in mouse liver lipid fractions. |
| doi_str_mv | 10.1093/ajcn/60.1.61 |
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Thirteen males and seven females were fed a nonpurified stock diet. Liver lipid fractions were separated and fatty acids quantitated by thin-layer and gas chromatography. There was a significant effect of obesity on 18:2ω6 in liver phospholipids (PL), cholesteryl esters, and triglycerides. PL 18:2ω6 was negatively correlated with carcass fat (r = −0.74, P < 0.001); 20:3ω6 was elevated in PL with increased obesity (P < 0.0001), and was correlated with carcass fat (r = 0.92, P < 0.0001); and 20:4ω6 in PL did not differ with obesity status. PL 20:3ω6 and 20:4ω6 were lower in males (P < 0.01 and 0.02, respectively) than in females. We conclude that obesity and sex affect distribution of ω6 essential fatty acids in mouse liver lipid fractions.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/60.1.61</identifier><identifier>PMID: 8017339</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Body Composition ; Body fat ; Body Weight ; Cholesterol Esters - analysis ; Cholesterol Esters - metabolism ; Chromatography, Gas ; Chromatography, Thin Layer ; essential fatty acids ; Fatty Acids, Essential - analysis ; Fatty Acids, Essential - metabolism ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated - analysis ; Fatty Acids, Unsaturated - metabolism ; Female ; Liver ; Liver - chemistry ; Liver - metabolism ; liver phospholipids ; Male ; Mead acid ; Medical sciences ; Metabolic diseases ; Mice ; Mice, Obese ; Models, Biological ; Obesity ; Obesity - genetics ; Obesity - metabolism ; Oils & fats ; Phospholipids - analysis ; Phospholipids - metabolism ; Rodents ; sex ; Sex Factors ; Triglycerides - analysis ; Triglycerides - metabolism</subject><ispartof>The American journal of clinical nutrition, 1994-07, Vol.60 (1), p.61-67</ispartof><rights>1994 American Society for Nutrition.</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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Thirteen males and seven females were fed a nonpurified stock diet. Liver lipid fractions were separated and fatty acids quantitated by thin-layer and gas chromatography. There was a significant effect of obesity on 18:2ω6 in liver phospholipids (PL), cholesteryl esters, and triglycerides. PL 18:2ω6 was negatively correlated with carcass fat (r = −0.74, P < 0.001); 20:3ω6 was elevated in PL with increased obesity (P < 0.0001), and was correlated with carcass fat (r = 0.92, P < 0.0001); and 20:4ω6 in PL did not differ with obesity status. PL 20:3ω6 and 20:4ω6 were lower in males (P < 0.01 and 0.02, respectively) than in females. We conclude that obesity and sex affect distribution of ω6 essential fatty acids in mouse liver lipid fractions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body Weight</subject><subject>Cholesterol Esters - analysis</subject><subject>Cholesterol Esters - metabolism</subject><subject>Chromatography, Gas</subject><subject>Chromatography, Thin Layer</subject><subject>essential fatty acids</subject><subject>Fatty Acids, Essential - analysis</subject><subject>Fatty Acids, Essential - metabolism</subject><subject>Fatty Acids, Omega-6</subject><subject>Fatty Acids, Unsaturated - analysis</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Female</subject><subject>Liver</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>liver phospholipids</subject><subject>Male</subject><subject>Mead acid</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Mice</subject><subject>Mice, Obese</subject><subject>Models, Biological</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><subject>Oils & fats</subject><subject>Phospholipids - analysis</subject><subject>Phospholipids - metabolism</subject><subject>Rodents</subject><subject>sex</subject><subject>Sex Factors</subject><subject>Triglycerides - analysis</subject><subject>Triglycerides - metabolism</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE2PFCEQhonRrLOrN68mxJg92bvQNNAcNxu_kkm86JkAXSiTbhiBXp1_L-NM9mC8UFTqyVOVF6FXlNxQotit2bl4K1pzI-gTtKGKjR3riXyKNoSQvlNU8OfospQdIbQfRnGBLkZCJWNqg6ZteICMvan1gI0LE3Zp2acSakix_XOG2VQo-FeoP7BN0-HIYhMnXOA3DhEbvKxzDd8hBoeXtBZo7wQzTh4nC810eIGeeTMXeHmuV-jbh_df7z912y8fP9_fbTs39LJ2dhjUKD0MjjvKKFgJxqmeGQ7OemqpocxxSryw0hBvOZemN6xXnIAlI2dX6Prk3ef0c4VS9RKKg3k2EdphWgouhBxpA9_8A-7SmmO7TfeMKioFGxv07gS5nErJ4PU-h8Xkg6ZEH5PXx-S1aI0WR-frs3O1C0yP8DnqNn97npvizOyziS6UR2ygisi_GnHCoAX1ECDr4gJEB1PI4KqeUvj__j_0Sp8L</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Phinney, SD</creator><creator>Fisler, JS</creator><creator>Tang, AB</creator><creator>Warden, CH</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Liver fatty acid composition correlates with body fat and sex in a multigenic mouse model of obesity</title><author>Phinney, SD ; Fisler, JS ; Tang, AB ; Warden, CH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-b44987fe4c5c131eb7eac923a5ecbf1b1a13c510f6b7a0fb557a2a32950eb0853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body Weight</topic><topic>Cholesterol Esters - analysis</topic><topic>Cholesterol Esters - metabolism</topic><topic>Chromatography, Gas</topic><topic>Chromatography, Thin Layer</topic><topic>essential fatty acids</topic><topic>Fatty Acids, Essential - analysis</topic><topic>Fatty Acids, Essential - metabolism</topic><topic>Fatty Acids, Omega-6</topic><topic>Fatty Acids, Unsaturated - analysis</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Female</topic><topic>Liver</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>liver phospholipids</topic><topic>Male</topic><topic>Mead acid</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Mice</topic><topic>Mice, Obese</topic><topic>Models, Biological</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><topic>Oils & fats</topic><topic>Phospholipids - analysis</topic><topic>Phospholipids - metabolism</topic><topic>Rodents</topic><topic>sex</topic><topic>Sex Factors</topic><topic>Triglycerides - analysis</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phinney, SD</creatorcontrib><creatorcontrib>Fisler, JS</creatorcontrib><creatorcontrib>Tang, AB</creatorcontrib><creatorcontrib>Warden, CH</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phinney, SD</au><au>Fisler, JS</au><au>Tang, AB</au><au>Warden, CH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver fatty acid composition correlates with body fat and sex in a multigenic mouse model of obesity</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>60</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>To determine whether there is altered liver lipid-fraction fatty acid distribution in a multigenic obese mouse model, we examined livers from eight lean (0.2–4.2% carcass fat), seven intermediate (5.7–13.8%), and five obese (20.2–48.7%) backcross progeny [(C57BL/6J × Mus spretus) × C57BL/6J] aged 2–3 mo. Thirteen males and seven females were fed a nonpurified stock diet. Liver lipid fractions were separated and fatty acids quantitated by thin-layer and gas chromatography. There was a significant effect of obesity on 18:2ω6 in liver phospholipids (PL), cholesteryl esters, and triglycerides. PL 18:2ω6 was negatively correlated with carcass fat (r = −0.74, P < 0.001); 20:3ω6 was elevated in PL with increased obesity (P < 0.0001), and was correlated with carcass fat (r = 0.92, P < 0.0001); and 20:4ω6 in PL did not differ with obesity status. PL 20:3ω6 and 20:4ω6 were lower in males (P < 0.01 and 0.02, respectively) than in females. We conclude that obesity and sex affect distribution of ω6 essential fatty acids in mouse liver lipid fractions.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8017339</pmid><doi>10.1093/ajcn/60.1.61</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Body Composition Body fat Body Weight Cholesterol Esters - analysis Cholesterol Esters - metabolism Chromatography, Gas Chromatography, Thin Layer essential fatty acids Fatty Acids, Essential - analysis Fatty Acids, Essential - metabolism Fatty Acids, Omega-6 Fatty Acids, Unsaturated - analysis Fatty Acids, Unsaturated - metabolism Female Liver Liver - chemistry Liver - metabolism liver phospholipids Male Mead acid Medical sciences Metabolic diseases Mice Mice, Obese Models, Biological Obesity Obesity - genetics Obesity - metabolism Oils & fats Phospholipids - analysis Phospholipids - metabolism Rodents sex Sex Factors Triglycerides - analysis Triglycerides - metabolism |
| title | Liver fatty acid composition correlates with body fat and sex in a multigenic mouse model of obesity |
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