Detection of cochlear dysfunction by the measurement of transiently evoked otoacoustic emissions in guinea pigs with autoimmune-induced labyrinthitis
For the evaluation of functional inner ear lesions caused by an autoimmune-induced labyrinthitis, transiently evoked otoacoustic emissions (TEOAEs) were detected in guinea pigs before and after transfer of sensitized lymphocytes from animals suffering from a labyrinthitis induced by the foreign prot...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 1994-04, Vol.251 (2), p.80-83 |
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| creator | ROSS, U. H ROGOWSKI, M REISS, G GLODDEK, B |
| description | For the evaluation of functional inner ear lesions caused by an autoimmune-induced labyrinthitis, transiently evoked otoacoustic emissions (TEOAEs) were detected in guinea pigs before and after transfer of sensitized lymphocytes from animals suffering from a labyrinthitis induced by the foreign protein keyhole limpet hemocyanin (KLH). Initially TEOAEs were detectable from 47 of 62 ears (76%) in healthy guinea pigs. These animals then were used as recipients for sensitized lymphocytes from donors exclusively. Three months after cell transfer the incidence of TEOAEs was reduced to 48% in animals receiving lymphocytes from donors sensitized with KLH intradermally and intracochlearly. In recipients of lymphocytes from donors sensitized only intradermally and in untreated animals no significant alteration of the TEOAE incidence was found. These findings showed strong correlation with those from scanning electron microscopy of the organ of Corti, indicating that the measurement of TEOAE is a useful, time-saving tool for the detection of cochlear dysfunction caused by sensitized lymphocytes in experimental animal. The present findings also show that the migration of sensitized lymphocytes actually leads to functional lesions in the cochlea. |
| doi_str_mv | 10.1007/BF00179897 |
| format | Article |
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These findings showed strong correlation with those from scanning electron microscopy of the organ of Corti, indicating that the measurement of TEOAE is a useful, time-saving tool for the detection of cochlear dysfunction caused by sensitized lymphocytes in experimental animal. The present findings also show that the migration of sensitized lymphocytes actually leads to functional lesions in the cochlea.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/BF00179897</identifier><identifier>PMID: 8024766</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Auditory Perception - physiology ; Autoimmune Diseases - pathology ; Autoimmune Diseases - physiopathology ; Biological and medical sciences ; Cochlea - physiopathology ; Cochlea - ultrastructure ; Ent. Stomatology ; Evoked Potentials, Auditory - physiology ; Freund's Adjuvant - administration & dosage ; Guinea Pigs ; Hemocyanins - administration & dosage ; Hemocyanins - immunology ; Immunization ; Injections ; Injections, Intradermal ; Investigative techniques, diagnostic techniques (general aspects) ; Labyrinthitis - immunology ; Labyrinthitis - pathology ; Labyrinthitis - physiopathology ; Lymphocyte Transfusion ; Lymphocytes - immunology ; Medical sciences ; Microscopy, Electron, Scanning ; Organ of Corti - ultrastructure ; Pathology. Cytology. Biochemistry. Spectrometry. 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H</creatorcontrib><creatorcontrib>ROGOWSKI, M</creatorcontrib><creatorcontrib>REISS, G</creatorcontrib><creatorcontrib>GLODDEK, B</creatorcontrib><title>Detection of cochlear dysfunction by the measurement of transiently evoked otoacoustic emissions in guinea pigs with autoimmune-induced labyrinthitis</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>For the evaluation of functional inner ear lesions caused by an autoimmune-induced labyrinthitis, transiently evoked otoacoustic emissions (TEOAEs) were detected in guinea pigs before and after transfer of sensitized lymphocytes from animals suffering from a labyrinthitis induced by the foreign protein keyhole limpet hemocyanin (KLH). Initially TEOAEs were detectable from 47 of 62 ears (76%) in healthy guinea pigs. These animals then were used as recipients for sensitized lymphocytes from donors exclusively. Three months after cell transfer the incidence of TEOAEs was reduced to 48% in animals receiving lymphocytes from donors sensitized with KLH intradermally and intracochlearly. In recipients of lymphocytes from donors sensitized only intradermally and in untreated animals no significant alteration of the TEOAE incidence was found. These findings showed strong correlation with those from scanning electron microscopy of the organ of Corti, indicating that the measurement of TEOAE is a useful, time-saving tool for the detection of cochlear dysfunction caused by sensitized lymphocytes in experimental animal. The present findings also show that the migration of sensitized lymphocytes actually leads to functional lesions in the cochlea.</description><subject>Animals</subject><subject>Auditory Perception - physiology</subject><subject>Autoimmune Diseases - pathology</subject><subject>Autoimmune Diseases - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cochlea - physiopathology</subject><subject>Cochlea - ultrastructure</subject><subject>Ent. Stomatology</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Freund's Adjuvant - administration & dosage</subject><subject>Guinea Pigs</subject><subject>Hemocyanins - administration & dosage</subject><subject>Hemocyanins - immunology</subject><subject>Immunization</subject><subject>Injections</subject><subject>Injections, Intradermal</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Labyrinthitis - immunology</subject><subject>Labyrinthitis - pathology</subject><subject>Labyrinthitis - physiopathology</subject><subject>Lymphocyte Transfusion</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Organ of Corti - ultrastructure</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Reflex, Acoustic - physiology</subject><subject>Scala Tympani</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EKkvhwh3JB8QBKe04dmL7CIUCUiUu5Rw5zqRrSOzFH0X5IfxfXO2qnEYz7zPfhLxmcMEA5OXHawAmtdLyCdkxwUUjZNs_JTvQXDZCSPmcvEjpJwB0QvMzcqagFbLvd-TvJ8xoswuehpnaYPcLmkinLc3FH-PjRvMe6YomlYgr-vyA5mh8ctVZNor34RdONORgbCgpO0txdSnV7ESdp3fFeTT04O4S_ePynpqSg1vX4rFxfiq2Ji9m3KLzee-ySy_Js9ksCV-d7Dn5cf359uprc_P9y7erDzeN5YzlhrdKMZgsAFdcm151bELNVSfGWfctk6DVBCAMouh1Z-aJtaM1XWckU1x2_Jy8O9Y9xPC7YMpDHdvishiPdZFB9l0vhIYKvj-CNoaUIs7DIbrVxG1gMDz8YPj_gwq_OVUt44rTI3o6etXfnnSTrFnmeknr0iMmgLVt7fkPk6KRHg</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>ROSS, U. H</creator><creator>ROGOWSKI, M</creator><creator>REISS, G</creator><creator>GLODDEK, B</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Detection of cochlear dysfunction by the measurement of transiently evoked otoacoustic emissions in guinea pigs with autoimmune-induced labyrinthitis</title><author>ROSS, U. H ; ROGOWSKI, M ; REISS, G ; GLODDEK, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-328810dc003839a6851de93854bf96217098d004aee4695afd12bca55a7183753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Auditory Perception - physiology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Autoimmune Diseases - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cochlea - physiopathology</topic><topic>Cochlea - ultrastructure</topic><topic>Ent. Stomatology</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Freund's Adjuvant - administration & dosage</topic><topic>Guinea Pigs</topic><topic>Hemocyanins - administration & dosage</topic><topic>Hemocyanins - immunology</topic><topic>Immunization</topic><topic>Injections</topic><topic>Injections, Intradermal</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Labyrinthitis - immunology</topic><topic>Labyrinthitis - pathology</topic><topic>Labyrinthitis - physiopathology</topic><topic>Lymphocyte Transfusion</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Organ of Corti - ultrastructure</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Reflex, Acoustic - physiology</topic><topic>Scala Tympani</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROSS, U. H</creatorcontrib><creatorcontrib>ROGOWSKI, M</creatorcontrib><creatorcontrib>REISS, G</creatorcontrib><creatorcontrib>GLODDEK, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROSS, U. H</au><au>ROGOWSKI, M</au><au>REISS, G</au><au>GLODDEK, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of cochlear dysfunction by the measurement of transiently evoked otoacoustic emissions in guinea pigs with autoimmune-induced labyrinthitis</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>251</volume><issue>2</issue><spage>80</spage><epage>83</epage><pages>80-83</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>For the evaluation of functional inner ear lesions caused by an autoimmune-induced labyrinthitis, transiently evoked otoacoustic emissions (TEOAEs) were detected in guinea pigs before and after transfer of sensitized lymphocytes from animals suffering from a labyrinthitis induced by the foreign protein keyhole limpet hemocyanin (KLH). Initially TEOAEs were detectable from 47 of 62 ears (76%) in healthy guinea pigs. These animals then were used as recipients for sensitized lymphocytes from donors exclusively. Three months after cell transfer the incidence of TEOAEs was reduced to 48% in animals receiving lymphocytes from donors sensitized with KLH intradermally and intracochlearly. In recipients of lymphocytes from donors sensitized only intradermally and in untreated animals no significant alteration of the TEOAE incidence was found. These findings showed strong correlation with those from scanning electron microscopy of the organ of Corti, indicating that the measurement of TEOAE is a useful, time-saving tool for the detection of cochlear dysfunction caused by sensitized lymphocytes in experimental animal. The present findings also show that the migration of sensitized lymphocytes actually leads to functional lesions in the cochlea.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8024766</pmid><doi>10.1007/BF00179897</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Auditory Perception - physiology Autoimmune Diseases - pathology Autoimmune Diseases - physiopathology Biological and medical sciences Cochlea - physiopathology Cochlea - ultrastructure Ent. Stomatology Evoked Potentials, Auditory - physiology Freund's Adjuvant - administration & dosage Guinea Pigs Hemocyanins - administration & dosage Hemocyanins - immunology Immunization Injections Injections, Intradermal Investigative techniques, diagnostic techniques (general aspects) Labyrinthitis - immunology Labyrinthitis - pathology Labyrinthitis - physiopathology Lymphocyte Transfusion Lymphocytes - immunology Medical sciences Microscopy, Electron, Scanning Organ of Corti - ultrastructure Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reflex, Acoustic - physiology Scala Tympani |
| title | Detection of cochlear dysfunction by the measurement of transiently evoked otoacoustic emissions in guinea pigs with autoimmune-induced labyrinthitis |
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