LH-RH analogue carrying a cytotoxic radical is internalized by rat pituitary cells in vitro

The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [ d-Lys 6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites fo...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1994, Vol.15 (2), p.359-366
Hauptverfasser:	Szöke, Balázs, Horváth, Judit, Halmos, Gábor, Rékási, Zoltán, Groot, Kate, Nagy, Attila, Schally, Andrew V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones - metabolism Antineoplastic Agents - metabolism Binding, Competitive Biological and medical sciences Biological Transport Cytotoxic peptides Drug targeting Endocytosis - physiology Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - metabolism Hormones. Endocrine system Iodine Radioisotopes Isotope Labeling Luteinizing Hormone - metabolism Male Medical sciences Membranes - metabolism Pharmacology. Drug treatments Pituitary Gland, Anterior - metabolism Rats Rats, Sprague-Dawley Receptor-mediated endocytosis Receptors, LHRH - metabolism
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