Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts
The technique of differential hybridization was used to compare gene transcription between normal oral mucosa and odontogenic keratocyst lining. Protease inhibitors, elafin and stefin-B as well as β-actin and two epithelial-specific small proline-rich (spr) proteins, which we have named SPRC and SPR...
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| Veröffentlicht in: | Archives of oral biology 1994-03, Vol.39 (3), p.251-259 |
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| container_title | Archives of oral biology |
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| creator | Robinson, P.A. Marley, J.J. High, A.S. Hume, W.J. |
| description | The technique of differential hybridization was used to compare gene transcription between normal oral mucosa and odontogenic keratocyst lining. Protease inhibitors, elafin and stefin-B as well as β-actin and two epithelial-specific small proline-rich (spr) proteins, which we have named SPRC and SPRK and which are distinct from salivary proline-rich proteins, were differentially expressed. Increased abundance of αI(I) collagen and elafin transcripts was demonstrated in the keratocyst, with decreased abundance of stefin B, SPRC and cytokeratins 4 and 13 transcripts compared to normal palatal mucosa. The deduced protein sequences of SPRC and SPRK were described and compared, and the relative abundance of their respective cDNAs in palatal and keratocyst libraries determined. Identification of factors controlling transcription of these genes could advance our understanding of the development of odontogenic keratocysts. |
| doi_str_mv | 10.1016/0003-9969(94)90051-5 |
| format | Article |
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Protease inhibitors, elafin and stefin-B as well as β-actin and two epithelial-specific small proline-rich (spr) proteins, which we have named SPRC and SPRK and which are distinct from salivary proline-rich proteins, were differentially expressed. Increased abundance of αI(I) collagen and elafin transcripts was demonstrated in the keratocyst, with decreased abundance of stefin B, SPRC and cytokeratins 4 and 13 transcripts compared to normal palatal mucosa. The deduced protein sequences of SPRC and SPRK were described and compared, and the relative abundance of their respective cDNAs in palatal and keratocyst libraries determined. Identification of factors controlling transcription of these genes could advance our understanding of the development of odontogenic keratocysts.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/0003-9969(94)90051-5</identifier><identifier>PMID: 8018055</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Actins - genetics ; Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Cornified Envelope Proline-Rich Proteins ; Cystatin B ; Cystatins - genetics ; Dentistry ; DNA Probes ; elafin ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Gene Expression Regulation ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; keratocyst ; Medical sciences ; Membrane Proteins ; Molecular Sequence Data ; Mouth Mucosa - chemistry ; Mouth Mucosa - enzymology ; Mouth Mucosa - metabolism ; Nucleic Acid Hybridization ; Odontogenic Cysts - genetics ; Otorhinolaryngology. Stomatology ; Proline - genetics ; Proteinase Inhibitory Proteins, Secretory ; Proteins - genetics ; Serine Proteinase Inhibitors - genetics ; small proline-rich protein ; stefin-B ; Transcription, Genetic ; Tumors</subject><ispartof>Archives of oral biology, 1994-03, Vol.39 (3), p.251-259</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-d37a3c0e4b2c1f40ad175c9c601747395f37224e9eb94b91683d47d02dbc29293</citedby><cites>FETCH-LOGICAL-c452t-d37a3c0e4b2c1f40ad175c9c601747395f37224e9eb94b91683d47d02dbc29293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0003996994900515$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4091265$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8018055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, P.A.</creatorcontrib><creatorcontrib>Marley, J.J.</creatorcontrib><creatorcontrib>High, A.S.</creatorcontrib><creatorcontrib>Hume, W.J.</creatorcontrib><title>Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>The technique of differential hybridization was used to compare gene transcription between normal oral mucosa and odontogenic keratocyst lining. Protease inhibitors, elafin and stefin-B as well as β-actin and two epithelial-specific small proline-rich (spr) proteins, which we have named SPRC and SPRK and which are distinct from salivary proline-rich proteins, were differentially expressed. Increased abundance of αI(I) collagen and elafin transcripts was demonstrated in the keratocyst, with decreased abundance of stefin B, SPRC and cytokeratins 4 and 13 transcripts compared to normal palatal mucosa. The deduced protein sequences of SPRC and SPRK were described and compared, and the relative abundance of their respective cDNAs in palatal and keratocyst libraries determined. Identification of factors controlling transcription of these genes could advance our understanding of the development of odontogenic keratocysts.</description><subject>Actins - genetics</subject><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cornified Envelope Proline-Rich Proteins</subject><subject>Cystatin B</subject><subject>Cystatins - genetics</subject><subject>Dentistry</subject><subject>DNA Probes</subject><subject>elafin</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Gene Expression Regulation</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>keratocyst</subject><subject>Medical sciences</subject><subject>Membrane Proteins</subject><subject>Molecular Sequence Data</subject><subject>Mouth Mucosa - chemistry</subject><subject>Mouth Mucosa - enzymology</subject><subject>Mouth Mucosa - metabolism</subject><subject>Nucleic Acid Hybridization</subject><subject>Odontogenic Cysts - genetics</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Proline - genetics</subject><subject>Proteinase Inhibitory Proteins, Secretory</subject><subject>Proteins - genetics</subject><subject>Serine Proteinase Inhibitors - genetics</subject><subject>small proline-rich protein</subject><subject>stefin-B</subject><subject>Transcription, Genetic</subject><subject>Tumors</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O1DAQhC0EWoaFNwDJB4TgELAT24kvSGj5lVbiAmfLsTuMIbEHtwPsU_DKODujOXJyW_VVqVVNyGPOXnLG1SvGWNdorfRzLV5oxiRv5B2y40OvGy6Zukt2Z-Q-eYD4vX6lUvyCXAyMD0zKHfn7NkwTZIgl2JnCn0MGxJAiTRM95FTAItAQ92EMJWVqo6e42HnexDlEaHJw-yMZIv0GEZCOUH4DRBpTrijdr4utebmOJSCucJuSfIolVUNw9AdkW5K7wYIPyb3JzgiPTu8l-fr-3Zerj8315w-frt5cN07ItjS-623nGIixdXwSzHreS6edYrwXfafl1PVtK0DDqMWouRo6L3rPWj-6Vre6uyTPjrl19Z8rYDFLQAfzbCOkFU2vpGrVMFRQHEGXE2KGyRxyWGy-MZyZ7Q5mK9lsJRstzO0djKy2J6f8dVzAn02n4qv-9KRbdHaeso0u4BkTTPNWbdjrIwa1i18BskEXIDrwIYMrxqfw_z3-Abdspyg</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Robinson, P.A.</creator><creator>Marley, J.J.</creator><creator>High, A.S.</creator><creator>Hume, W.J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940301</creationdate><title>Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts</title><author>Robinson, P.A. ; Marley, J.J. ; High, A.S. ; Hume, W.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-d37a3c0e4b2c1f40ad175c9c601747395f37224e9eb94b91683d47d02dbc29293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Actins - genetics</topic><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cornified Envelope Proline-Rich Proteins</topic><topic>Cystatin B</topic><topic>Cystatins - genetics</topic><topic>Dentistry</topic><topic>DNA Probes</topic><topic>elafin</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Gene Expression Regulation</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>keratocyst</topic><topic>Medical sciences</topic><topic>Membrane Proteins</topic><topic>Molecular Sequence Data</topic><topic>Mouth Mucosa - chemistry</topic><topic>Mouth Mucosa - enzymology</topic><topic>Mouth Mucosa - metabolism</topic><topic>Nucleic Acid Hybridization</topic><topic>Odontogenic Cysts - genetics</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Proline - genetics</topic><topic>Proteinase Inhibitory Proteins, Secretory</topic><topic>Proteins - genetics</topic><topic>Serine Proteinase Inhibitors - genetics</topic><topic>small proline-rich protein</topic><topic>stefin-B</topic><topic>Transcription, Genetic</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, P.A.</creatorcontrib><creatorcontrib>Marley, J.J.</creatorcontrib><creatorcontrib>High, A.S.</creatorcontrib><creatorcontrib>Hume, W.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, P.A.</au><au>Marley, J.J.</au><au>High, A.S.</au><au>Hume, W.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>39</volume><issue>3</issue><spage>251</spage><epage>259</epage><pages>251-259</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>The technique of differential hybridization was used to compare gene transcription between normal oral mucosa and odontogenic keratocyst lining. Protease inhibitors, elafin and stefin-B as well as β-actin and two epithelial-specific small proline-rich (spr) proteins, which we have named SPRC and SPRK and which are distinct from salivary proline-rich proteins, were differentially expressed. Increased abundance of αI(I) collagen and elafin transcripts was demonstrated in the keratocyst, with decreased abundance of stefin B, SPRC and cytokeratins 4 and 13 transcripts compared to normal palatal mucosa. The deduced protein sequences of SPRC and SPRK were described and compared, and the relative abundance of their respective cDNAs in palatal and keratocyst libraries determined. Identification of factors controlling transcription of these genes could advance our understanding of the development of odontogenic keratocysts.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8018055</pmid><doi>10.1016/0003-9969(94)90051-5</doi><tpages>9</tpages></addata></record> |
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| ispartof | Archives of oral biology, 1994-03, Vol.39 (3), p.251-259 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Actins - genetics Amino Acid Sequence Base Sequence Biological and medical sciences Cornified Envelope Proline-Rich Proteins Cystatin B Cystatins - genetics Dentistry DNA Probes elafin Facial bones, jaws, teeth, parodontium: diseases, semeiology Gene Expression Regulation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans keratocyst Medical sciences Membrane Proteins Molecular Sequence Data Mouth Mucosa - chemistry Mouth Mucosa - enzymology Mouth Mucosa - metabolism Nucleic Acid Hybridization Odontogenic Cysts - genetics Otorhinolaryngology. Stomatology Proline - genetics Proteinase Inhibitory Proteins, Secretory Proteins - genetics Serine Proteinase Inhibitors - genetics small proline-rich protein stefin-B Transcription, Genetic Tumors |
| title | Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts |
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