Differential regulation of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene during oligodendrocyte development
The two major isoforms of 2′,3′-cyclic nucleotide phosphodiesterase (CNP), 48 and 46 kDa, have recently been shown to be produced from a single gene by alternative splicing. In addition, messenger RNA encoding the larger isoform is transcribed from a separate promoter, approximately 1 kb upstream fr...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1994-06, Vol.12 (6), p.1363-1375 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Scherer, Steven S. Braun, Peter E. Grinspan, Judith Collarini, Ellen Wang, D.-y. Kamholz, John |
| description | The two major isoforms of 2′,3′-cyclic nucleotide phosphodiesterase (CNP), 48 and 46 kDa, have recently been shown to be produced from a single gene by alternative splicing. In addition, messenger RNA encoding the larger isoform is transcribed from a separate promoter, approximately 1 kb upstream from that encoding the smaller isoform. We have investigated the expression of these two CNP isoforms and have found that they are differentially expressed during the process of oligodendrocyte maturation. In oligodendrocyte precursors, only the mRNA encoding the larger protein is found. At the time of oligodendrocyte differentiation, however, both CNP mRNAs are induced. These patterns of CNP expression are likely due to stage-specific transcriptional regulation of the two CNP promoters during the process of oligodendrocyte differentiation. |
| doi_str_mv | 10.1016/0896-6273(94)90451-0 |
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In addition, messenger RNA encoding the larger isoform is transcribed from a separate promoter, approximately 1 kb upstream from that encoding the smaller isoform. We have investigated the expression of these two CNP isoforms and have found that they are differentially expressed during the process of oligodendrocyte maturation. In oligodendrocyte precursors, only the mRNA encoding the larger protein is found. At the time of oligodendrocyte differentiation, however, both CNP mRNAs are induced. 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These patterns of CNP expression are likely due to stage-specific transcriptional regulation of the two CNP promoters during the process of oligodendrocyte differentiation.</description><subject>2',3'-Cyclic-Nucleotide Phosphodiesterases - biosynthesis</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>Brain - enzymology</subject><subject>Brain - growth & development</subject><subject>Cells, Cultured</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Isoenzymes - biosynthesis</subject><subject>Neurons - enzymology</subject><subject>Oligodendroglia - drug effects</subject><subject>Oligodendroglia - enzymology</subject><subject>Optic Nerve - enzymology</subject><subject>Optic Nerve - growth & development</subject><subject>Platelet-Derived Growth Factor - pharmacology</subject><subject>Promoter Regions, Genetic</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Transcription, Genetic</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuKVDEQDaKMPaN_oJCVKHg16bw3gozjAwbc6DrkJpWeSPqmTe4d6J3f5Cf5Jaanm1nqoqqg6tSp4hyEnlHyhhIq3xJt5CDXir00_JUhXNCBPEArSowaODXmIVrdQx6j89Z-EEK5MPQMnWlCKeN0hfYfUoxQYZqTy7jCZsluTmXCJeL5BvD6z6_fr1lPg9_7nDyeFp-hzCkAvmvvbkrrERK0GaprgDcwAQ5LTdMGl5w2JcAUavH7ubfhFnLZbfu9J-hRdLnB01O9QN8_Xn27_Dxcf_305fL99eA5FWRQI2WaRlACBDi5JsqsAwsias-UEYxrLgkRwug4OqElAcEIAQNxVKN2wC7QiyPvrpafS__SblPzkLOboCzNKikk5Vz9F0ilpFpy1oH8CPS1tFYh2l1NW1f3lhJ7sMYedLcH3a3h9s4aS_ra8xP_Mm4h3C-dvOjzd8c5dDVuE1TbfILJQ0gV_GxDSf8-8Bf0Z6GI</recordid><startdate>199406</startdate><enddate>199406</enddate><creator>Scherer, Steven S.</creator><creator>Braun, Peter E.</creator><creator>Grinspan, Judith</creator><creator>Collarini, Ellen</creator><creator>Wang, D.-y.</creator><creator>Kamholz, John</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199406</creationdate><title>Differential regulation of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene during oligodendrocyte development</title><author>Scherer, Steven S. ; Braun, Peter E. ; Grinspan, Judith ; Collarini, Ellen ; Wang, D.-y. ; Kamholz, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4150-7b1381fe75e5ea620792d3d5f8c379534846005598fba5860e5300e9efb7b8ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>2',3'-Cyclic-Nucleotide Phosphodiesterases - biosynthesis</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>Brain - enzymology</topic><topic>Brain - growth & development</topic><topic>Cells, Cultured</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Isoenzymes - biosynthesis</topic><topic>Neurons - enzymology</topic><topic>Oligodendroglia - drug effects</topic><topic>Oligodendroglia - enzymology</topic><topic>Optic Nerve - enzymology</topic><topic>Optic Nerve - growth & development</topic><topic>Platelet-Derived Growth Factor - pharmacology</topic><topic>Promoter Regions, Genetic</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scherer, Steven S.</creatorcontrib><creatorcontrib>Braun, Peter E.</creatorcontrib><creatorcontrib>Grinspan, Judith</creatorcontrib><creatorcontrib>Collarini, Ellen</creatorcontrib><creatorcontrib>Wang, D.-y.</creatorcontrib><creatorcontrib>Kamholz, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scherer, Steven S.</au><au>Braun, Peter E.</au><au>Grinspan, Judith</au><au>Collarini, Ellen</au><au>Wang, D.-y.</au><au>Kamholz, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential regulation of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene during oligodendrocyte development</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1994-06</date><risdate>1994</risdate><volume>12</volume><issue>6</issue><spage>1363</spage><epage>1375</epage><pages>1363-1375</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>The two major isoforms of 2′,3′-cyclic nucleotide phosphodiesterase (CNP), 48 and 46 kDa, have recently been shown to be produced from a single gene by alternative splicing. In addition, messenger RNA encoding the larger isoform is transcribed from a separate promoter, approximately 1 kb upstream from that encoding the smaller isoform. We have investigated the expression of these two CNP isoforms and have found that they are differentially expressed during the process of oligodendrocyte maturation. In oligodendrocyte precursors, only the mRNA encoding the larger protein is found. At the time of oligodendrocyte differentiation, however, both CNP mRNAs are induced. These patterns of CNP expression are likely due to stage-specific transcriptional regulation of the two CNP promoters during the process of oligodendrocyte differentiation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8011341</pmid><doi>10.1016/0896-6273(94)90451-0</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0896-6273 1097-4199 |
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| subjects | 2',3'-Cyclic-Nucleotide Phosphodiesterases - biosynthesis Aging - metabolism Animals Blotting, Northern Blotting, Western Brain - enzymology Brain - growth & development Cells, Cultured Gene Expression Regulation, Enzymologic Humans Immunohistochemistry In Situ Hybridization Isoenzymes - biosynthesis Neurons - enzymology Oligodendroglia - drug effects Oligodendroglia - enzymology Optic Nerve - enzymology Optic Nerve - growth & development Platelet-Derived Growth Factor - pharmacology Promoter Regions, Genetic Rats Rats, Sprague-Dawley RNA, Messenger - analysis RNA, Messenger - biosynthesis Transcription, Genetic |
| title | Differential regulation of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene during oligodendrocyte development |
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