Background Ca2+ influx mediated by a dihydropyridine- and voltage-insensitive channel in pancreatic beta-cells. Modulation by Ni2+, diphenylamine-2-carboxylate, and glucose metabolism

A stepwise increase in extracellular Ca2+ concentration ([Ca2+]o) can evoke insulin release from pancreatic islets in the absence of secretagogues. We have investigated the ionic mechanism underlying this secretory response by recording intracellular free Ca2+ concentration ([Ca2+]i) from single mou...

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Veröffentlicht in:	The Journal of biological chemistry 1994-06, Vol.269 (25), p.17095-17103
Hauptverfasser:	SILVA, A. M, ROSARIO, L. M, SANTOS, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Cell membranes. Ionic channels. Membrane pores Cell structures and functions Female Fundamental and applied biological sciences. Psychology Glucose - metabolism Ion Channel Gating - drug effects Islets of Langerhans - metabolism Membrane Potentials Mice Molecular and cellular biology Nickel - pharmacology Nifedipine - pharmacology ortho-Aminobenzoates - pharmacology
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