Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies

IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector function...

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Veröffentlicht in:	Bio/Technology 1994-07, Vol.12 (7), p.683-688
Hauptverfasser:	Smith, Richard I. F., Morrison, Sherie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Complement C1 - metabolism Complement C1q - metabolism Fundamental and applied biological sciences. Psychology Genetic Engineering Half-Life Health. Pharmaceutical industry Hemolysis Humans Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - metabolism Immunoglobulin M - metabolism Industrial applications and implications. Economical aspects Life Sciences Mice Mice, Inbred BALB C Monoclonal antibodies Mutation Production of active biomolecules Receptors, Fc - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism
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