Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies
IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector function...
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| Veröffentlicht in: | Bio/Technology 1994-07, Vol.12 (7), p.683-688 |
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| container_title | Bio/Technology |
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| creator | Smith, Richard I. F. Morrison, Sherie L. |
| description | IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through γ specific Fc receptors. Using a generalizable technique we have produced IgM-like polymers of IgG that possess both the Fcγ receptor binding properties of IgG and the more potent complement activity of IgM. |
| doi_str_mv | 10.1038/nbt0794-683 |
| format | Article |
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Pharmaceutical industry</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - metabolism</subject><subject>Immunoglobulin M - metabolism</subject><subject>Industrial applications and implications. 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Pharmaceutical industry</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - metabolism</topic><topic>Immunoglobulin M - metabolism</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Monoclonal antibodies</topic><topic>Mutation</topic><topic>Production of active biomolecules</topic><topic>Receptors, Fc - metabolism</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Recombinant Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Richard I. 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F.</au><au>Morrison, Sherie L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies</atitle><jtitle>Bio/Technology</jtitle><stitle>Nat Biotechnol</stitle><addtitle>Biotechnology (N Y)</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>12</volume><issue>7</issue><spage>683</spage><epage>688</epage><pages>683-688</pages><issn>0733-222X</issn><issn>1087-0156</issn><eissn>1546-1696</eissn><eissn>2331-3684</eissn><abstract>IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through γ specific Fc receptors. 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| ispartof | Bio/Technology, 1994-07, Vol.12 (7), p.683-688 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Agriculture Animals Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Complement C1 - metabolism Complement C1q - metabolism Fundamental and applied biological sciences. Psychology Genetic Engineering Half-Life Health. Pharmaceutical industry Hemolysis Humans Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - metabolism Immunoglobulin M - metabolism Industrial applications and implications. Economical aspects Life Sciences Mice Mice, Inbred BALB C Monoclonal antibodies Mutation Production of active biomolecules Receptors, Fc - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism |
| title | Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies |
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