Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production

Bioefficiencies of α-, γ- and δ-tocopherol in comparison with all-rac-α-tocopherol were established in broiler chickens. For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks...

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Veröffentlicht in:British journal of nutrition 1994-04, Vol.71 (4), p.605-614
Hauptverfasser: Fuhrmann, Herbert, Balthazary, Sukurani T., Sallmann, Hans-Peter
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container_title British journal of nutrition
container_volume 71
creator Fuhrmann, Herbert
Balthazary, Sukurani T.
Sallmann, Hans-Peter
description Bioefficiencies of α-, γ- and δ-tocopherol in comparison with all-rac-α-tocopherol were established in broiler chickens. For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks of feeding, the animals were killed to obtain blood and liver samples. The ex vivo tests used were detergent induced haemolysis and pentane production by liver microsomes. Bioefficiencies were calculated by comparison of the dose–response curves. It is concluded that haemolysis and pentane production are appropriate indicators of the bioefficiency of tocopherols in broiler chickens. The values obtained by both tests hardly differed and agree well with the figures previously obtained from rats and other species.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry
subjects alpha-Tocopherol - analogs & derivatives
Animals
Bioefficiency
Biological Availability
Chicken
Chickens - metabolism
Dose-Response Relationship, Drug
Haemolysis
Hemolysis
Male
Microsomes, Liver - metabolism
Pentane
Pentanes - metabolism
Random Allocation
Tocopherols
Vitamin E
Vitamin E - analogs & derivatives
Vitamin E - metabolism
Vitamin E - pharmacokinetics
title Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production
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