Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production
Bioefficiencies of α-, γ- and δ-tocopherol in comparison with all-rac-α-tocopherol were established in broiler chickens. For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks...
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Veröffentlicht in: | British journal of nutrition 1994-04, Vol.71 (4), p.605-614 |
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creator | Fuhrmann, Herbert Balthazary, Sukurani T. Sallmann, Hans-Peter |
description | Bioefficiencies of α-, γ- and δ-tocopherol in comparison with all-rac-α-tocopherol were established in broiler chickens. For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks of feeding, the animals were killed to obtain blood and liver samples. The ex vivo tests used were detergent induced haemolysis and pentane production by liver microsomes. Bioefficiencies were calculated by comparison of the dose–response curves. It is concluded that haemolysis and pentane production are appropriate indicators of the bioefficiency of tocopherols in broiler chickens. The values obtained by both tests hardly differed and agree well with the figures previously obtained from rats and other species. |
doi_str_mv | 10.1079/BJN19940166 |
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For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks of feeding, the animals were killed to obtain blood and liver samples. The ex vivo tests used were detergent induced haemolysis and pentane production by liver microsomes. Bioefficiencies were calculated by comparison of the dose–response curves. It is concluded that haemolysis and pentane production are appropriate indicators of the bioefficiency of tocopherols in broiler chickens. The values obtained by both tests hardly differed and agree well with the figures previously obtained from rats and other species.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19940166</identifier><identifier>PMID: 8011612</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>alpha-Tocopherol - analogs & derivatives ; Animals ; Bioefficiency ; Biological Availability ; Chicken ; Chickens - metabolism ; Dose-Response Relationship, Drug ; Haemolysis ; Hemolysis ; Male ; Microsomes, Liver - metabolism ; Pentane ; Pentanes - metabolism ; Random Allocation ; Tocopherols ; Vitamin E ; Vitamin E - analogs & derivatives ; Vitamin E - metabolism ; Vitamin E - pharmacokinetics</subject><ispartof>British journal of nutrition, 1994-04, Vol.71 (4), p.605-614</ispartof><rights>Copyright © The Nutrition Society 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-58603db36413510794bfc2a999c60dde9f645810e761422f6e4b15ca1ed519183</citedby><cites>FETCH-LOGICAL-c341t-58603db36413510794bfc2a999c60dde9f645810e761422f6e4b15ca1ed519183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8011612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuhrmann, Herbert</creatorcontrib><creatorcontrib>Balthazary, Sukurani T.</creatorcontrib><creatorcontrib>Sallmann, Hans-Peter</creatorcontrib><title>Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Bioefficiencies of α-, γ- and δ-tocopherol in comparison with all-rac-α-tocopherol were established in broiler chickens. For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks of feeding, the animals were killed to obtain blood and liver samples. The ex vivo tests used were detergent induced haemolysis and pentane production by liver microsomes. Bioefficiencies were calculated by comparison of the dose–response curves. It is concluded that haemolysis and pentane production are appropriate indicators of the bioefficiency of tocopherols in broiler chickens. The values obtained by both tests hardly differed and agree well with the figures previously obtained from rats and other species.</description><subject>alpha-Tocopherol - analogs & derivatives</subject><subject>Animals</subject><subject>Bioefficiency</subject><subject>Biological Availability</subject><subject>Chicken</subject><subject>Chickens - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Haemolysis</subject><subject>Hemolysis</subject><subject>Male</subject><subject>Microsomes, Liver - metabolism</subject><subject>Pentane</subject><subject>Pentanes - metabolism</subject><subject>Random Allocation</subject><subject>Tocopherols</subject><subject>Vitamin E</subject><subject>Vitamin E - analogs & derivatives</subject><subject>Vitamin E - metabolism</subject><subject>Vitamin E - pharmacokinetics</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUMFu1DAUtBCoLC0nzkg-cUEBv8R24iOt2AJatSAVrpZjP7Nuk3ixE4n9e7zaVeGA9KSnpxnNzBtCXgF7B6xV7y-_3IBSnIGUT8gKeCuqWsr6KVkxxtoKgIvn5EXO9-XsgKkzctYxAAn1iqTLENH7YANOdk-jpy54jwmnmc7Rxt0WUxwyDRO122AfcKIml8lYxtF-T7cGxzjsc8h0xjxTMzk6BptijqMZ6K4omQnpLkW32DnE6YI882bI-PK0z8n39ce7q0_V5vb689WHTWUbDnMlOska1zeSQyMOf_Le29oopaxkzqHykovyDrYSeF17ibwHYQ2gE6Cga87Jm6Nusf61lGh6DNniMJQ4ccm6lUJIAXUhvj0SD6FzQq93KYwm7TUwfXDW_zRc2K9Psks_onvknioteHXEQ57x9yNs0oOWbdMKLa-_adisv_If606Lv3xrxj4F9xP1fVzSVKr5r_8fr5iUQw</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Fuhrmann, Herbert</creator><creator>Balthazary, Sukurani T.</creator><creator>Sallmann, Hans-Peter</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199404</creationdate><title>Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production</title><author>Fuhrmann, Herbert ; Balthazary, Sukurani T. ; Sallmann, Hans-Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-58603db36413510794bfc2a999c60dde9f645810e761422f6e4b15ca1ed519183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>alpha-Tocopherol - analogs & derivatives</topic><topic>Animals</topic><topic>Bioefficiency</topic><topic>Biological Availability</topic><topic>Chicken</topic><topic>Chickens - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Haemolysis</topic><topic>Hemolysis</topic><topic>Male</topic><topic>Microsomes, Liver - metabolism</topic><topic>Pentane</topic><topic>Pentanes - metabolism</topic><topic>Random Allocation</topic><topic>Tocopherols</topic><topic>Vitamin E</topic><topic>Vitamin E - analogs & derivatives</topic><topic>Vitamin E - metabolism</topic><topic>Vitamin E - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuhrmann, Herbert</creatorcontrib><creatorcontrib>Balthazary, Sukurani T.</creatorcontrib><creatorcontrib>Sallmann, Hans-Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuhrmann, Herbert</au><au>Balthazary, Sukurani T.</au><au>Sallmann, Hans-Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1994-04</date><risdate>1994</risdate><volume>71</volume><issue>4</issue><spage>605</spage><epage>614</epage><pages>605-614</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Bioefficiencies of α-, γ- and δ-tocopherol in comparison with all-rac-α-tocopherol were established in broiler chickens. For this, 1-d-old male broiler chickens received a diet deficient in vitamin E and supplemented with increasing doses of the corresponding tocopheryl acetates. After 2 and 3 weeks of feeding, the animals were killed to obtain blood and liver samples. The ex vivo tests used were detergent induced haemolysis and pentane production by liver microsomes. Bioefficiencies were calculated by comparison of the dose–response curves. It is concluded that haemolysis and pentane production are appropriate indicators of the bioefficiency of tocopherols in broiler chickens. The values obtained by both tests hardly differed and agree well with the figures previously obtained from rats and other species.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>8011612</pmid><doi>10.1079/BJN19940166</doi><tpages>10</tpages></addata></record> |
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subjects | alpha-Tocopherol - analogs & derivatives Animals Bioefficiency Biological Availability Chicken Chickens - metabolism Dose-Response Relationship, Drug Haemolysis Hemolysis Male Microsomes, Liver - metabolism Pentane Pentanes - metabolism Random Allocation Tocopherols Vitamin E Vitamin E - analogs & derivatives Vitamin E - metabolism Vitamin E - pharmacokinetics |
title | Bioefficiency of different tocopherols in chicken as assessed by haemolysis test and microsomal pentane production |
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