Muscarinic receptor-mediated inhibition of mitogenesis via a protein kinase C-independent mechanism in m1-transfected A9 L cells

Previous studies have shown that activation of various PI-coupled receptors stimulates DNA synthesis in some cells, and inhibits DNA synthesis in others. in order to study this effect further, we measured carbachol-mediated [ 3H]thymidine incorporation in m1-transfected A9 L cells and in m1-transfec...

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Veröffentlicht in:	Cellular signalling 1994, Vol.6 (1), p.103-108
Hauptverfasser:	Baumgold, Jesse, Dyer, Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Carbachol - pharmacology Cell physiology Cells, Cultured CHO Cells Cricetinae DNA - biosynthesis DNA - drug effects DNA Replication - drug effects Dose-Response Relationship, Drug Down-Regulation Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Receptors, Muscarinic - metabolism Responses to growth factors, tumor promotors, other factors Thymidine - metabolism Transfection
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