A Method for the Pharmacokinetic Analysis of Serum Cefotiam Levels during Cardiopulmonary Bypass Surgery

In our previous study on serum concentrations of CTM during open-heart operations, it was found in several cases that the serum concentrations after the institution of the cardiopulmonary bypass (CPB) showed an initial transient rise and subsequent slow decline. However, the mechanism of the phenomenon has not been clarified pharmacokinetically. In this paper, a method is proposed by which the serum concentration during CPB can be analyzed simply by using the volume of priming solution (Vp) and rate of decrease (μ) of transfer (k12) and elimination (ke) rate constants when the pharmacokinetic parameters before or after CPB are available. By using this method, the serum concentrations of patients undergoing open-heart operation were successfully analyzed.