The influence of serotonergic inputs on peptide neurons in the rat suprachiasmatic nucleus: An immunocytochemical study
The influence of serotonin (5-hydroxytryptamine; 5-HT) innervation on peptide-containing neurons in the rat suprachiasmatic nucleus (SCN) was investigated by peroxidase-anti-peroxidase (PAP) immunocytochemistry. The 5-HT neuronal system was chemically severed by 5,6-dihydroxytryptamine (5,6-DHT) inj...
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| Veröffentlicht in: | Neuroscience letters 1985-11, Vol.61 (3), p.273-277 |
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| container_title | Neuroscience letters |
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| creator | Kawakami, Fumio Okamura, Hitoshi Fukui, Kenji Yanaihara, Chizuko Yanaihara, Noboru Nakajima, Teruo Ibata, Yasuhiko |
| description | The influence of serotonin (5-hydroxytryptamine; 5-HT) innervation on peptide-containing neurons in the rat suprachiasmatic nucleus (SCN) was investigated by peroxidase-anti-peroxidase (PAP) immunocytochemistry. The 5-HT neuronal system was chemically severed by 5,6-dihydroxytryptamine (5,6-DHT) injection into the medial forebrain bundle bilaterally. After this treatment, a marked decrease of vasoactive intestinal peptide (VIP)-like immunoreactivity in neuronal perikarya occurred in the SCN corresponding to a decrease in number of 5-HT immunoreactive fibers and terminals. However, no alteration of arginine-vasopressin-like immunoreactivity was detected between 5,6-DHT-treated animals and the controls. It is speculated that VIP-like immunoreactive neurons play an important role in the SCN under the influence of strong 5-HT innervation. |
| doi_str_mv | 10.1016/0304-3940(85)90476-8 |
| format | Article |
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The 5-HT neuronal system was chemically severed by 5,6-dihydroxytryptamine (5,6-DHT) injection into the medial forebrain bundle bilaterally. After this treatment, a marked decrease of vasoactive intestinal peptide (VIP)-like immunoreactivity in neuronal perikarya occurred in the SCN corresponding to a decrease in number of 5-HT immunoreactive fibers and terminals. However, no alteration of arginine-vasopressin-like immunoreactivity was detected between 5,6-DHT-treated animals and the controls. 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Psychology ; Immunoenzyme Techniques ; Male ; rat ; Rats ; Rats, Inbred Strains ; serotonin ; Serotonin - metabolism ; suprachiasmatic nucleus ; Suprachiasmatic Nucleus - metabolism ; Vasoactive Intestinal Peptide - metabolism ; vasoactive intestinal polypeptide ; vasopressin ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1985-11, Vol.61 (3), p.273-277</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-9b52a3859c459f71e642e25d2ef6209635dda74107b8711a116491709eb56bf63</citedby><cites>FETCH-LOGICAL-c483t-9b52a3859c459f71e642e25d2ef6209635dda74107b8711a116491709eb56bf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(85)90476-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8598185$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3909002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakami, Fumio</creatorcontrib><creatorcontrib>Okamura, Hitoshi</creatorcontrib><creatorcontrib>Fukui, Kenji</creatorcontrib><creatorcontrib>Yanaihara, Chizuko</creatorcontrib><creatorcontrib>Yanaihara, Noboru</creatorcontrib><creatorcontrib>Nakajima, Teruo</creatorcontrib><creatorcontrib>Ibata, Yasuhiko</creatorcontrib><title>The influence of serotonergic inputs on peptide neurons in the rat suprachiasmatic nucleus: An immunocytochemical study</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The influence of serotonin (5-hydroxytryptamine; 5-HT) innervation on peptide-containing neurons in the rat suprachiasmatic nucleus (SCN) was investigated by peroxidase-anti-peroxidase (PAP) immunocytochemistry. The 5-HT neuronal system was chemically severed by 5,6-dihydroxytryptamine (5,6-DHT) injection into the medial forebrain bundle bilaterally. After this treatment, a marked decrease of vasoactive intestinal peptide (VIP)-like immunoreactivity in neuronal perikarya occurred in the SCN corresponding to a decrease in number of 5-HT immunoreactive fibers and terminals. However, no alteration of arginine-vasopressin-like immunoreactivity was detected between 5,6-DHT-treated animals and the controls. It is speculated that VIP-like immunoreactive neurons play an important role in the SCN under the influence of strong 5-HT innervation.</description><subject>5,6-dihydroxytryptamine</subject><subject>5,6-Dihydroxytryptamine - pharmacology</subject><subject>Animals</subject><subject>Arginine Vasopressin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>serotonin</subject><subject>Serotonin - metabolism</subject><subject>suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><subject>vasoactive intestinal polypeptide</subject><subject>vasopressin</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoY9v6DxSyENFFaVKVR2UWwjD4ggE34zqkUrfsSFVS5qH0vzdlN73Uu7mLc87l8h2EnlPylhIq3pGOsKZTjLzu-RtFmBRN_wDtaC_bRirZPkS7i-UxepLSD0IIp5xdoatOEUVIu0O_7w-AnZ_mAt4CDhNOEEMOHuJ3Z6uylpxw8HiFNbsRsIcSg09VwblGo8k4lTUae3AmLSbXkC92hpKu8Y3HblmKD_aYgz3A4qyZccplPD5FjyYzJ3h23nv07eOH-9vPzd3XT19ub-4ay_ouN2rgrel6rizjapIUBGuh5WMLk2iJEh0fRyMZJXLoJaWGUsEUlUTBwMUwiW6PXp3urjH8LJCyXlyyMM_GQyhJS8F5SyX_r5EyRkRXZ4_YyWhjSCnCpNfoFhOPmhK9FaM36nqjrnuu_xaj-xp7cb5fhgXGS-jcRNVfnnWTKqUpGm9dutgqgp7225vvTzao0H45iDpZt1U3ugg26zG4f__xB1Wpqmw</recordid><startdate>19851111</startdate><enddate>19851111</enddate><creator>Kawakami, Fumio</creator><creator>Okamura, Hitoshi</creator><creator>Fukui, Kenji</creator><creator>Yanaihara, Chizuko</creator><creator>Yanaihara, Noboru</creator><creator>Nakajima, Teruo</creator><creator>Ibata, Yasuhiko</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19851111</creationdate><title>The influence of serotonergic inputs on peptide neurons in the rat suprachiasmatic nucleus: An immunocytochemical study</title><author>Kawakami, Fumio ; Okamura, Hitoshi ; Fukui, Kenji ; Yanaihara, Chizuko ; Yanaihara, Noboru ; Nakajima, Teruo ; Ibata, Yasuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-9b52a3859c459f71e642e25d2ef6209635dda74107b8711a116491709eb56bf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>5,6-dihydroxytryptamine</topic><topic>5,6-Dihydroxytryptamine - pharmacology</topic><topic>Animals</topic><topic>Arginine Vasopressin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>serotonin</topic><topic>Serotonin - metabolism</topic><topic>suprachiasmatic nucleus</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><topic>vasoactive intestinal polypeptide</topic><topic>vasopressin</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, Fumio</creatorcontrib><creatorcontrib>Okamura, Hitoshi</creatorcontrib><creatorcontrib>Fukui, Kenji</creatorcontrib><creatorcontrib>Yanaihara, Chizuko</creatorcontrib><creatorcontrib>Yanaihara, Noboru</creatorcontrib><creatorcontrib>Nakajima, Teruo</creatorcontrib><creatorcontrib>Ibata, Yasuhiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, Fumio</au><au>Okamura, Hitoshi</au><au>Fukui, Kenji</au><au>Yanaihara, Chizuko</au><au>Yanaihara, Noboru</au><au>Nakajima, Teruo</au><au>Ibata, Yasuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of serotonergic inputs on peptide neurons in the rat suprachiasmatic nucleus: An immunocytochemical study</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1985-11-11</date><risdate>1985</risdate><volume>61</volume><issue>3</issue><spage>273</spage><epage>277</epage><pages>273-277</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The influence of serotonin (5-hydroxytryptamine; 5-HT) innervation on peptide-containing neurons in the rat suprachiasmatic nucleus (SCN) was investigated by peroxidase-anti-peroxidase (PAP) immunocytochemistry. The 5-HT neuronal system was chemically severed by 5,6-dihydroxytryptamine (5,6-DHT) injection into the medial forebrain bundle bilaterally. After this treatment, a marked decrease of vasoactive intestinal peptide (VIP)-like immunoreactivity in neuronal perikarya occurred in the SCN corresponding to a decrease in number of 5-HT immunoreactive fibers and terminals. However, no alteration of arginine-vasopressin-like immunoreactivity was detected between 5,6-DHT-treated animals and the controls. It is speculated that VIP-like immunoreactive neurons play an important role in the SCN under the influence of strong 5-HT innervation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3909002</pmid><doi>10.1016/0304-3940(85)90476-8</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1985-11, Vol.61 (3), p.273-277 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5,6-dihydroxytryptamine 5,6-Dihydroxytryptamine - pharmacology Animals Arginine Vasopressin - metabolism Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology Immunoenzyme Techniques Male rat Rats Rats, Inbred Strains serotonin Serotonin - metabolism suprachiasmatic nucleus Suprachiasmatic Nucleus - metabolism Vasoactive Intestinal Peptide - metabolism vasoactive intestinal polypeptide vasopressin Vertebrates: nervous system and sense organs |
| title | The influence of serotonergic inputs on peptide neurons in the rat suprachiasmatic nucleus: An immunocytochemical study |
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