Evidence that weaning stimulates the developmental expression of a δ-opioid receptor subtype in the rat
To study whether weaning stimulates the development of a subtype of the δ-opioid receptor we have measured antinociceptive activity of putative δ 1 (DELT 1) and δ 2 (DSLET) agonists in weaned and non-weaned 25-day-old rats. In weaned rats, DSLET produced antinociception reversed by the δ 2-antagonis...
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| Veröffentlicht in: | Brain research. Developmental brain research 1994-03, Vol.78 (1), p.147-150 |
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| container_title | Brain research. Developmental brain research |
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| creator | Kitchen, Ian Crook, Tracy J. Muhammad, Bala Y. Hill, Raymond G. |
| description | To study whether weaning stimulates the development of a subtype of the δ-opioid receptor we have measured antinociceptive activity of putative δ
1 (DELT 1) and δ
2 (DSLET) agonists in weaned and non-weaned 25-day-old rats. In weaned rats, DSLET produced antinociception reversed by the δ
2-antagonist naltriben, but in non-weaned rats DSLET had no effect. Responses to DELT 1 were evident in both weaned and non-weaned rats and were not antagonised by naltriben. This is the first evidence that δ-receptor subtypes develop independently and suggests that weaning is the stimulus for the expression of the δ
2-subtype. |
| doi_str_mv | 10.1016/0165-3806(94)90020-5 |
| format | Article |
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1 (DELT 1) and δ
2 (DSLET) agonists in weaned and non-weaned 25-day-old rats. In weaned rats, DSLET produced antinociception reversed by the δ
2-antagonist naltriben, but in non-weaned rats DSLET had no effect. Responses to DELT 1 were evident in both weaned and non-weaned rats and were not antagonised by naltriben. This is the first evidence that δ-receptor subtypes develop independently and suggests that weaning is the stimulus for the expression of the δ
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1 (DELT 1) and δ
2 (DSLET) agonists in weaned and non-weaned 25-day-old rats. In weaned rats, DSLET produced antinociception reversed by the δ
2-antagonist naltriben, but in non-weaned rats DSLET had no effect. Responses to DELT 1 were evident in both weaned and non-weaned rats and were not antagonised by naltriben. This is the first evidence that δ-receptor subtypes develop independently and suggests that weaning is the stimulus for the expression of the δ
2-subtype.</description><subject>Analgesics - antagonists & inhibitors</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enkephalin, Leucine - analogs & derivatives</subject><subject>Enkephalin, Leucine - pharmacology</subject><subject>Expression</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Naltrexone - analogs & derivatives</subject><subject>Naltrexone - pharmacology</subject><subject>Naltriben</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Neuropeptide receptors</subject><subject>Oligopeptides - antagonists & inhibitors</subject><subject>Oligopeptides - pharmacology</subject><subject>Ontogeny</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Opioid, delta - biosynthesis</subject><subject>Receptors, Opioid, delta - drug effects</subject><subject>Weaning</subject><subject>δ-Opioid receptor</subject><subject>δ-Subtype</subject><issn>0165-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhr0AlVJ4Ayp5UaGyCPiaxJtKVVUuUiU2sLbGzqR1lcSp7Rza9-I5eCZyeo7OEhajkWa-f2R9JuQdZx854_WntXQlW1afG_XBMCZYpV-Q48P4FXmd8z1jjMuWH5GjljHV1OaY3F1vQoeTR1ruoNBfCFOYbmkuYVwGKJjXOdIONzjEecSpwEDxcU6Yc4gTjT0F-ud3FecQQ0cTepxLTDQvrjzNSMP0nE9Q3pCXPQwZ3-77Cfn5-frH1dfq5vuXb1eXN5VXvCmVMdIZdFr7VgBqxXTdtzVnqjUoOBjRMq14L5wT4FrotZdS9rXz3isQ2skT8n53d07xYcFc7Biyx2GACeOSbVNrzYXh_wV5bbhmTbOCagf6FHNO2Ns5hRHSk-XMbu3brWa71WyNss_2rV5jp_v7ixuxO4T26tf92X4P2cPQJ5h8yAdMMa6lkCt2scNwlbYJmGz2YfthXVhtF9vF8O93_AUw2KQH</recordid><startdate>19940318</startdate><enddate>19940318</enddate><creator>Kitchen, Ian</creator><creator>Crook, Tracy J.</creator><creator>Muhammad, Bala Y.</creator><creator>Hill, Raymond G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940318</creationdate><title>Evidence that weaning stimulates the developmental expression of a δ-opioid receptor subtype in the rat</title><author>Kitchen, Ian ; Crook, Tracy J. ; Muhammad, Bala Y. ; Hill, Raymond G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-993b9eb55c82ae54056f8610489e21a9280541f2bb2ab8af5c333f6bccc4a25b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analgesics - antagonists & inhibitors</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enkephalin, Leucine - analogs & derivatives</topic><topic>Enkephalin, Leucine - pharmacology</topic><topic>Expression</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Naltrexone - analogs & derivatives</topic><topic>Naltrexone - pharmacology</topic><topic>Naltriben</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Neuropeptide receptors</topic><topic>Oligopeptides - antagonists & inhibitors</topic><topic>Oligopeptides - pharmacology</topic><topic>Ontogeny</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Opioid, delta - biosynthesis</topic><topic>Receptors, Opioid, delta - drug effects</topic><topic>Weaning</topic><topic>δ-Opioid receptor</topic><topic>δ-Subtype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitchen, Ian</creatorcontrib><creatorcontrib>Crook, Tracy J.</creatorcontrib><creatorcontrib>Muhammad, Bala Y.</creatorcontrib><creatorcontrib>Hill, Raymond G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. 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1 (DELT 1) and δ
2 (DSLET) agonists in weaned and non-weaned 25-day-old rats. In weaned rats, DSLET produced antinociception reversed by the δ
2-antagonist naltriben, but in non-weaned rats DSLET had no effect. Responses to DELT 1 were evident in both weaned and non-weaned rats and were not antagonised by naltriben. This is the first evidence that δ-receptor subtypes develop independently and suggests that weaning is the stimulus for the expression of the δ
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| language | eng |
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| subjects | Analgesics - antagonists & inhibitors Analgesics - pharmacology Animals Biological and medical sciences Cell receptors Cell structures and functions Dose-Response Relationship, Drug Enkephalin, Leucine - analogs & derivatives Enkephalin, Leucine - pharmacology Expression Female Fundamental and applied biological sciences. Psychology Male Molecular and cellular biology Naltrexone - analogs & derivatives Naltrexone - pharmacology Naltriben Narcotic Antagonists - pharmacology Neuropeptide receptors Oligopeptides - antagonists & inhibitors Oligopeptides - pharmacology Ontogeny Rats Rats, Wistar Receptors, Opioid, delta - biosynthesis Receptors, Opioid, delta - drug effects Weaning δ-Opioid receptor δ-Subtype |
| title | Evidence that weaning stimulates the developmental expression of a δ-opioid receptor subtype in the rat |
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